Frizzled class receptor 6

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ubiquitin protein ligase binding Source: RGDInferred from sequence orthologyⁱ
  • "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."
    Hao H.X., Xie Y., Zhang Y., Charlat O., Oster E., Avello M., Lei H., Mickanin C., Liu D., Ruffner H., Mao X., Ma Q., Zamponi R., Bouwmeester T., Finan P.M., Kirschner M.W., Porter J.A., Serluca F.C., Cong F.
    Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]
• Wnt-activated receptor activity Source: RGDInferred from sequence orthologyⁱ
  • "Interaction of frizzled related protein (FRP) with Wnt ligands and the frizzled receptor suggests alternative mechanisms for FRP inhibition of Wnt signaling."
    Bafico A., Gazit A., Pramila T., Finch P.W., Yaniv A., Aaronson S.A.
    J. Biol. Chem. 274:16180-16187(1999) [PubMed] [Europe PMC] [Abstract]
• Wnt-protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells."
    Lyons J.P., Mueller U.W., Ji H., Everett C., Fang X., Hsieh J.C., Barth A.M., McCrea P.D.
    Exp. Cell Res. 298:369-387(2004) [PubMed] [Europe PMC] [Abstract]
  • "Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex."
    Yamamoto S., Nishimura O., Misaki K., Nishita M., Minami Y., Yonemura S., Tarui H., Sasaki H.
    Dev. Cell 15:23-36(2008) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• canonical Wnt signaling pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell proliferation in midbrain Source: RGDInferred from sequence orthologyⁱ
  • "Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect."
    Stuebner S., Faus-Kessler T., Fischer T., Wurst W., Prakash N.
    Dev. Dyn. 239:246-260(2010) [PubMed] [Europe PMC] [Abstract]
• embryonic nail plate morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "Frizzled6 deficiency disrupts the differentiation process of nail development."
    Cui C.Y., Klar J., Georgii-Heming P., Frojmark A.S., Baig S.M., Schlessinger D., Dahl N.
    J. Invest. Dermatol. 133:1990-1997(2013) [PubMed] [Europe PMC] [Abstract]
• establishment of body hair planar orientation Source: RGDInferred from sequence orthologyⁱ
  • "Identification of Astrotactin2 as a Genetic Modifier That Regulates the Global Orientation of Mammalian Hair Follicles."
    Chang H., Cahill H., Smallwood P.M., Wang Y., Nathans J.
    PLoS Genet. 11:e1005532-e1005532(2015) [PubMed] [Europe PMC] [Abstract]
• establishment of planar polarity Source: RGDInferred from sequence orthologyⁱ
  • "The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells."
    Wang Y., Guo N., Nathans J.
    J. Neurosci. 26:2147-2156(2006) [PubMed] [Europe PMC] [Abstract]
• hair follicle development Source: RGDInferred from sequence orthologyⁱ
  • "Frizzled6 controls hair patterning in mice."
    Guo N., Hawkins C., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 101:9277-9281(2004) [PubMed] [Europe PMC] [Abstract]
  • "Order from disorder: Self-organization in mammalian hair patterning."
    Wang Y., Badea T., Nathans J.
    Proc. Natl. Acad. Sci. U.S.A. 103:19800-19805(2006) [PubMed] [Europe PMC] [Abstract]
• inner ear morphogenesis Source: RGDInferred from sequence orthologyⁱ
  • "The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells."
    Wang Y., Guo N., Nathans J.
    J. Neurosci. 26:2147-2156(2006) [PubMed] [Europe PMC] [Abstract]
• midbrain development Source: RGDInferred from sequence orthologyⁱ
  • "Fzd3 and Fzd6 deficiency results in a severe midbrain morphogenesis defect."
    Stuebner S., Faus-Kessler T., Fischer T., Wurst W., Prakash N.
    Dev. Dyn. 239:246-260(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of canonical Wnt signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade."
    Golan T., Yaniv A., Bafico A., Liu G., Gazit A.
    J. Biol. Chem. 279:14879-14888(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: RGDInferred from sequence orthologyⁱ
  • "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade."
    Golan T., Yaniv A., Bafico A., Liu G., Gazit A.
    J. Biol. Chem. 279:14879-14888(2004) [PubMed] [Europe PMC] [Abstract]
• neural tube closure Source: RGDInferred from sequence orthologyⁱ
  • "The role of Frizzled3 and Frizzled6 in neural tube closure and in the planar polarity of inner-ear sensory hair cells."
    Wang Y., Guo N., Nathans J.
    J. Neurosci. 26:2147-2156(2006) [PubMed] [Europe PMC] [Abstract]
• non-canonical Wnt signaling pathway Source: RGDInferred from sequence orthologyⁱ
  • "The human Frizzled 6 (HFz6) acts as a negative regulator of the canonical Wnt. beta-catenin signaling cascade."
    Golan T., Yaniv A., Bafico A., Liu G., Gazit A.
    J. Biol. Chem. 279:14879-14888(2004) [PubMed] [Europe PMC] [Abstract]
• platelet activation Source: RGDInferred from sequence orthologyⁱ
  • "Canonical Wnt signaling negatively regulates platelet function."
    Steele B.M., Harper M.T., Macaulay I.C., Morrell C.N., Perez-Tamayo A., Foy M., Habas R., Poole A.W., Fitzgerald D.J., Maguire P.B.
    Proc. Natl. Acad. Sci. U.S.A. 106:19836-19841(2009) [PubMed] [Europe PMC] [Abstract]
• Wnt signaling pathway, planar cell polarity pathway Source: RGDInferred from sequence orthologyⁱ
  • "Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex."
    Yamamoto S., Nishimura O., Misaki K., Nishita M., Minami Y., Yonemura S., Tarui H., Sasaki H.
    Dev. Cell 15:23-36(2008) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• ubiquitin protein ligase binding Source: RGDInferred from sequence orthologyⁱ
  • "ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive manner."
    Hao H.X., Xie Y., Zhang Y., Charlat O., Oster E., Avello M., Lei H., Mickanin C., Liu D., Ruffner H., Mao X., Ma Q., Zamponi R., Bouwmeester T., Finan P.M., Kirschner M.W., Porter J.A., Serluca F.C., Cong F.
    Nature 485:195-200(2012) [PubMed] [Europe PMC] [Abstract]
• Wnt-protein binding Source: RGDInferred from sequence orthologyⁱ
  • "Wnt-4 activates the canonical beta-catenin-mediated Wnt pathway and binds Frizzled-6 CRD: functional implications of Wnt/beta-catenin activity in kidney epithelial cells."
    Lyons J.P., Mueller U.W., Ji H., Everett C., Fang X., Hsieh J.C., Barth A.M., McCrea P.D.
    Exp. Cell Res. 298:369-387(2004) [PubMed] [Europe PMC] [Abstract]
  • "Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex."
    Yamamoto S., Nishimura O., Misaki K., Nishita M., Minami Y., Yonemura S., Tarui H., Sasaki H.
    Dev. Cell 15:23-36(2008) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MEASPFLSAC ILLPLIRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD 
        60         70         80         90        100
QGIAAVEMEH FLPLANLECS PNIEMFLCQA FVPTCTEQID VVSPCRKLCE 
       110        120        130        140        150
KILSDCQKLM DTFGIRWPEE LECHRLPYCD GAVPVTSDPH TELFGPQKKT 
       160        170        180        190        200
DQVPRDIGFW CPKHLRTSGD QGYRFLGIDQ CAPPCPNMYF KSDELDFAKS 
       210        220        230        240        250
FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC YSIVSLMYFV 
       260        270        280        290        300
GFLLGNSTAC NKADEKLELG NTVVLGSKNK ACSVVFMFLY FFTMAGTVWW 
       310        320        330        340        350
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGMPGFLTV MLLAMNKVEG 
       360        370        380        390        400
DNISGVCFVG LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI 
       410        420        430        440        450
QHDGRNQEKL KKFMIRIGVF SGLYLVPLVT LLGCYVYELV NRVTWEMTWF 
       460        470        480        490        500
SDHCHQYRIP CPYQANPKAR PELALFMIKY LMTLIVGISA VFWVGSKKTC 
       510        520        530        540        550
TEWAGFCKRN RKRDPISESR RVLQESCEFF LKHNSKVRHK KKHGKPGSHK 
       560        570        580        590        600
LKVISKSMGT STGVTTDHGT SAVAIADHDY LGQETSAEVQ TSPEASLKEG 
       610        620        630        640        650
RADRANTPRA KGPDCGEPAS TAASNSKFSG DQIDRKSRAG SVKEKSSVSE 
       660        670        680        690        700
GAPSEGRVSP KGVPGTGLME CTLQIPSSPE PNSLKGSTSL LVRSASGTRK 
       710
EQGAGGHSDT                                             

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ