UniProtKB - G3V6L1 (G3V6L1_RAT)
Protein
Submitted name:
Frizzled class receptor 6
Gene
Fzd6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Caution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- ubiquitin protein ligase binding Source: Ensembl
- Wnt-activated receptor activity Source: GO_Central
- Wnt-protein binding Source: GO_Central
GO - Biological processi
- canonical Wnt signaling pathway Source: GO_Central
- cell proliferation in midbrain Source: Ensembl
- embryonic nail plate morphogenesis Source: Ensembl
- establishment of body hair planar orientation Source: Ensembl
- hair follicle development Source: Ensembl
- inner ear morphogenesis Source: Ensembl
- negative regulation of canonical Wnt signaling pathway Source: Ensembl
- negative regulation of DNA-binding transcription factor activity Source: Ensembl
- neural tube closure Source: Ensembl
- non-canonical Wnt signaling pathway Source: GO_Central
- platelet activation Source: Ensembl
- Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
Keywordsi
Molecular function | Developmental proteinSAAS annotation, ReceptorSAAS annotation |
Biological process | Wnt signaling pathwaySAAS annotation |
Enzyme and pathway databases
Reactomei | R-RNO-4086398 Ca2+ pathway R-RNO-4086400 PCP/CE pathway R-RNO-4641263 Regulation of FZD by ubiquitination |
Names & Taxonomyi
Protein namesi | Submitted name: Frizzled class receptor 6ImportedSubmitted name: Frizzled homolog 6 (Drosophila)Imported |
Gene namesi | Name:Fzd6Imported ORF Names:rCG_59567Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 628816 Fzd6 |
Subcellular locationi
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Ensembl
Plasma Membrane
- apicolateral plasma membrane Source: Ensembl
- plasma membrane Source: GO_Central
Other locations
- apical part of cell Source: Ensembl
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 201 – 222 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 234 – 254 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 287 – 312 | HelicalSequence analysisAdd BLAST | 26 | |
Transmembranei | 324 – 345 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 369 – 393 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 413 – 440 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 473 – 494 | HelicalSequence analysisAdd BLAST | 22 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 18 | Sequence analysisAdd BLAST | 18 | |
ChainiPRO_5015091654 | 19 – 710 | Sequence analysisAdd BLAST | 692 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 24 ↔ 85 | PROSITE-ProRule annotation | ||
Disulfide bondi | 32 ↔ 78 | PROSITE-ProRule annotation | ||
Disulfide bondi | 99 ↔ 123 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationSAAS annotationExpressioni
Gene expression databases
Bgeei | ENSRNOG00000004660 Expressed in 9 organ(s), highest expression level in lung |
Interactioni
GO - Molecular functioni
- ubiquitin protein ligase binding Source: Ensembl
- Wnt-protein binding Source: GO_Central
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006195 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 19 – 132 | FZInterPro annotationAdd BLAST | 114 | |
Domaini | 195 – 502 | G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST | 308 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 583 – 710 | DisorderedSequence analysisAdd BLAST | 128 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 671 – 696 | PolarSequence analysisAdd BLAST | 26 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor Fz/Smo family.SAAS annotation
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotationPhylogenomic databases
eggNOGi | KOG3577 Eukaryota ENOG410XRC8 LUCA |
GeneTreei | ENSGT00940000158485 |
KOi | K02376 |
OMAi | TIMLLAM |
OrthoDBi | 330751at2759 |
TreeFami | TF317907 |
Family and domain databases
CDDi | cd07450 CRD_FZ6, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526 Frizzled/SFRP IPR000539 Frizzled/Smoothened_TM IPR020067 Frizzled_dom IPR036790 Frizzled_dom_sf IPR041770 FZ6_CRD IPR026543 FZD6 IPR017981 GPCR_2-like |
PANTHERi | PTHR11309 PTHR11309, 1 hit PTHR11309:SF75 PTHR11309:SF75, 1 hit |
Pfami | View protein in Pfam PF01534 Frizzled, 1 hit PF01392 Fz, 1 hit |
PRINTSi | PR00489 FRIZZLED |
SMARTi | View protein in SMART SM00063 FRI, 1 hit SM01330 Frizzled, 1 hit |
SUPFAMi | SSF63501 SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038 FZ, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
i Sequence
Sequence statusi: Complete.
G3V6L1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEASPFLSAC ILLPLIRGHS LFTCEPITVP RCMKMAYNMT FFPNLMGHYD
60 70 80 90 100
QGIAAVEMEH FLPLANLECS PNIEMFLCQA FVPTCTEQID VVSPCRKLCE
110 120 130 140 150
KILSDCQKLM DTFGIRWPEE LECHRLPYCD GAVPVTSDPH TELFGPQKKT
160 170 180 190 200
DQVPRDIGFW CPKHLRTSGD QGYRFLGIDQ CAPPCPNMYF KSDELDFAKS
210 220 230 240 250
FIGIVSIFCL CATLFTFLTF LIDVRRFRYP ERPIIYYSVC YSIVSLMYFV
260 270 280 290 300
GFLLGNSTAC NKADEKLELG NTVVLGSKNK ACSVVFMFLY FFTMAGTVWW
310 320 330 340 350
VILTITWFLA AGRKWSCEAI EQKAVWFHAV AWGMPGFLTV MLLAMNKVEG
360 370 380 390 400
DNISGVCFVG LYDLDASRYF VLLPLCLCVF VGLSLLLAGI ISLNHVRQVI
410 420 430 440 450
QHDGRNQEKL KKFMIRIGVF SGLYLVPLVT LLGCYVYELV NRVTWEMTWF
460 470 480 490 500
SDHCHQYRIP CPYQANPKAR PELALFMIKY LMTLIVGISA VFWVGSKKTC
510 520 530 540 550
TEWAGFCKRN RKRDPISESR RVLQESCEFF LKHNSKVRHK KKHGKPGSHK
560 570 580 590 600
LKVISKSMGT STGVTTDHGT SAVAIADHDY LGQETSAEVQ TSPEASLKEG
610 620 630 640 650
RADRANTPRA KGPDCGEPAS TAASNSKFSG DQIDRKSRAG SVKEKSSVSE
660 670 680 690 700
GAPSEGRVSP KGVPGTGLME CTLQIPSSPE PNSLKGSTSL LVRSASGTRK
710
EQGAGGHSDT
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC121173 Genomic DNA No translation available. CH473950 Genomic DNA Translation: EDM16356.1 |
RefSeqi | NP_001124008.1, NM_001130536.1 XP_017450173.1, XM_017594684.1 XP_017450174.1, XM_017594685.1 XP_017450175.1, XM_017594686.1 |
Genome annotation databases
Ensembli | ENSRNOT00000006195; ENSRNOP00000006195; ENSRNOG00000004660 |
GeneIDi | 282581 |
KEGGi | rno:282581 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC121173 Genomic DNA No translation available. CH473950 Genomic DNA Translation: EDM16356.1 |
RefSeqi | NP_001124008.1, NM_001130536.1 XP_017450173.1, XM_017594684.1 XP_017450174.1, XM_017594685.1 XP_017450175.1, XM_017594686.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000006195 |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
Ensembli | ENSRNOT00000006195; ENSRNOP00000006195; ENSRNOG00000004660 |
GeneIDi | 282581 |
KEGGi | rno:282581 |
Organism-specific databases
CTDi | 8323 |
RGDi | 628816 Fzd6 |
Phylogenomic databases
eggNOGi | KOG3577 Eukaryota ENOG410XRC8 LUCA |
GeneTreei | ENSGT00940000158485 |
KOi | K02376 |
OMAi | TIMLLAM |
OrthoDBi | 330751at2759 |
TreeFami | TF317907 |
Enzyme and pathway databases
Reactomei | R-RNO-4086398 Ca2+ pathway R-RNO-4086400 PCP/CE pathway R-RNO-4641263 Regulation of FZD by ubiquitination |
Gene expression databases
Bgeei | ENSRNOG00000004660 Expressed in 9 organ(s), highest expression level in lung |
Family and domain databases
CDDi | cd07450 CRD_FZ6, 1 hit |
Gene3Di | 1.10.2000.10, 1 hit |
InterProi | View protein in InterPro IPR015526 Frizzled/SFRP IPR000539 Frizzled/Smoothened_TM IPR020067 Frizzled_dom IPR036790 Frizzled_dom_sf IPR041770 FZ6_CRD IPR026543 FZD6 IPR017981 GPCR_2-like |
PANTHERi | PTHR11309 PTHR11309, 1 hit PTHR11309:SF75 PTHR11309:SF75, 1 hit |
Pfami | View protein in Pfam PF01534 Frizzled, 1 hit PF01392 Fz, 1 hit |
PRINTSi | PR00489 FRIZZLED |
SMARTi | View protein in SMART SM00063 FRI, 1 hit SM01330 Frizzled, 1 hit |
SUPFAMi | SSF63501 SSF63501, 1 hit |
PROSITEi | View protein in PROSITE PS50038 FZ, 1 hit PS50261 G_PROTEIN_RECEP_F2_4, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V6L1_RAT | |
Accessioni | G3V6L1Primary (citable) accession number: G3V6L1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | October 16, 2019 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |