UniProtKB - G3V671 (G3V671_RAT)
Protein
Submitted name:
CD80 antigen, isoform CRA_a
Gene
Cd80
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- coreceptor activity Source: InterPro
GO - Biological processi
- cell surface receptor signaling pathway Source: GO_Central
- cellular response to lipopolysaccharide Source: RGD
- immune response Source: GO_Central
- negative regulation of T cell proliferation Source: GO_Central
- positive regulation of alpha-beta T cell proliferation Source: RGD
- positive regulation of peptidyl-tyrosine phosphorylation Source: RGD
- positive regulation of T cell proliferation Source: RGD
- signal transduction Source: GO_Central
- T cell costimulation Source: RGD
Enzyme and pathway databases
Reactomei | R-RNO-1257604, PIP3 activates AKT signaling R-RNO-389356, CD28 co-stimulation R-RNO-389357, CD28 dependent PI3K/Akt signaling R-RNO-389359, CD28 dependent Vav1 pathway R-RNO-389513, CTLA4 inhibitory signaling R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Names & Taxonomyi
Protein namesi | Submitted name: CD80 antigen, isoform CRA_aImportedSubmitted name: Cd80 moleculeImported |
Gene namesi | Name:Cd80Imported ORF Names:rCG_52759Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 2314, Cd80 |
Subcellular locationi
Plasma Membrane
- external side of plasma membrane Source: RGD
Other locations
- cell surface Source: RGD
- integral component of membrane Source: UniProtKB-KW
- protein complex involved in cell adhesion Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 21 – 40 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 263 – 288 | HelicalSequence analysisAdd BLAST | 26 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSRNOG00000001527, Expressed in liver and 20 other tissues |
ExpressionAtlasi | G3V671, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 17 – 137 | Ig-likeInterPro annotationAdd BLAST | 121 | |
Domaini | 148 – 235 | Ig-likeInterPro annotationAdd BLAST | 88 |
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502S5B5, Eukaryota |
GeneTreei | ENSGT00940000162632 |
OMAi | HMTSVML |
OrthoDBi | 1083437at2759 |
TreeFami | TF351094 |
Family and domain databases
CDDi | cd16083, IgC_CD80, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR037676, CD80_IgC IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
G3V671-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAYSCQLMQE SPLLGFPRLR FIHLFVLLLV GLFQISSGIV GQVSKSVREK
60 70 80 90 100
ALLSCDYKFC SEEQSIHRIY WQKHDKMVLS VISGVPEVWP EYKNRTVYDI
110 120 130 140 150
ANNYSFSLLG LILSDRGTYT CVVQRYEGGS YVVKHLTTVE LSVRADFPTP
160 170 180 190 200
NITESGNPSA DIKRITCFAS GGFPKPRLSW LENGRELNGI NTTISQDPES
210 220 230 240 250
ELYTISSQLD FNTTYDHFID CFIEYGDAHV SQNFTWEKPP EDPPDEKQTI
260 270 280 290 300
PFAWAGSDAV KAIIIFFIAI TVIAVIAAIA IIIFCITVKF RRCFRRRNEA
310 320
SRETNKNLYI GPVEAAAEQT V
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A0G2K0F2 | A0A0G2K0F2_RAT | Cd80 molecule | Cd80 | 294 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC140752 Genomic DNA No translation available. CH473967 Genomic DNA Translation: EDM11215.1 CH473967 Genomic DNA Translation: EDM11218.1 |
RefSeqi | XP_006248427.1, XM_006248365.3 XP_017453373.1, XM_017597884.1 XP_017453374.1, XM_017597885.1 |
Genome annotation databases
Ensembli | ENSRNOT00000002089; ENSRNOP00000002089; ENSRNOG00000001527 |
GeneIDi | 25408 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC140752 Genomic DNA No translation available. CH473967 Genomic DNA Translation: EDM11215.1 CH473967 Genomic DNA Translation: EDM11218.1 |
RefSeqi | XP_006248427.1, XM_006248365.3 XP_017453373.1, XM_017597884.1 XP_017453374.1, XM_017597885.1 |
3D structure databases
SMRi | G3V671 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000002089 |
Genome annotation databases
Ensembli | ENSRNOT00000002089; ENSRNOP00000002089; ENSRNOG00000001527 |
GeneIDi | 25408 |
Organism-specific databases
CTDi | 941 |
RGDi | 2314, Cd80 |
Phylogenomic databases
eggNOGi | ENOG502S5B5, Eukaryota |
GeneTreei | ENSGT00940000162632 |
OMAi | HMTSVML |
OrthoDBi | 1083437at2759 |
TreeFami | TF351094 |
Enzyme and pathway databases
Reactomei | R-RNO-1257604, PIP3 activates AKT signaling R-RNO-389356, CD28 co-stimulation R-RNO-389357, CD28 dependent PI3K/Akt signaling R-RNO-389359, CD28 dependent Vav1 pathway R-RNO-389513, CTLA4 inhibitory signaling R-RNO-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling |
Gene expression databases
Bgeei | ENSRNOG00000001527, Expressed in liver and 20 other tissues |
ExpressionAtlasi | G3V671, baseline and differential |
Family and domain databases
CDDi | cd16083, IgC_CD80, 1 hit |
Gene3Di | 2.60.40.10, 2 hits |
InterProi | View protein in InterPro IPR013162, CD80_C2-set IPR037676, CD80_IgC IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003599, Ig_sub |
Pfami | View protein in Pfam PF08205, C2-set_2, 1 hit |
SMARTi | View protein in SMART SM00409, IG, 1 hit |
SUPFAMi | SSF48726, SSF48726, 2 hits |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V671_RAT | |
Accessioni | G3V671Primary (citable) accession number: G3V671 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 73 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |