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Entry version 62 (29 Sep 2021)
Sequence version 1 (16 Nov 2011)
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Protein

2'-5'-oligoadenylate synthase-like protein 1

Gene

Oasl

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Does not have 2'-5'-OAS activity, but can bind double-stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Biological processAntiviral defense, Immunity, Innate immunity

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
2'-5'-oligoadenylate synthase-like protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Oasl
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12
  • UP000234681 Componentsi: Chromosome 12, Unassembled WGS sequence

Organism-specific databases

Rat genome database

More...
RGDi
1308586, Oasl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004186331 – 5122'-5'-oligoadenylate synthase-like protein 1Add BLAST512

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
G3V645

PRoteomics IDEntifications database

More...
PRIDEi
G3V645

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
G3V645

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
G3V645

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000001187, Expressed in stomach and 22 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
G3V645, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Specifically interacts with the ligand binding domain of the thyroid receptor (TR). TRIP14 does not require the presence of thyroid hormone for its interaction. Binds MBD1 (By similarity).

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000001570

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3V645

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini351 – 430Ubiquitin-like 1PROSITE-ProRule annotationAdd BLAST80
Domaini431 – 507Ubiquitin-like 2PROSITE-ProRule annotationAdd BLAST77

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the 2-5A synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0001, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00510000046406

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_040930_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3V645

Identification of Orthologs from Complete Genome Data

More...
OMAi
QRACQCL

Database of Orthologous Groups

More...
OrthoDBi
611234at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
G3V645

TreeFam database of animal gene trees

More...
TreeFami
TF329749

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05400, NT_2-5OAS_ClassI-CCAase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.460.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018952, 2-5-oligoAdlate_synth_1_dom2/C
IPR026774, 2-5A_synthase
IPR006117, 2-5OAS_C_CS
IPR006116, NT_2-5OAS_ClassI-CCAase
IPR043519, NT_sf
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR11258, PTHR11258, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF10421, OAS1_C, 1 hit
PF00240, ubiquitin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00213, UBQ, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF54236, SSF54236, 2 hits
SSF81301, SSF81301, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00833, 25A_SYNTH_2, 1 hit
PS50152, 25A_SYNTH_3, 1 hit
PS50053, UBIQUITIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3V645-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAQELYSF PASKLDSFVA QWLQPTREWK EEVLETVQTV EQFLRQENFR
60 70 80 90 100
GERGPAQDVR VLKVLKVGCF GNGTVLRSTT DVELVVFLSC FHSFQEEAKH
110 120 130 140 150
HQAVLRLIQK RMSYCRDLLD LGLSNLSVIE EVPSSLIFTI QTRETWEPIT
160 170 180 190 200
VTIVPAFRAL GPSCPNSAEV YVNLIKANGY PGNFSPSFSE LQRSFVKHRP
210 220 230 240 250
TKLKSLLRLV KHWYQQYVRD KCPRANLPPL YALELLTVYA WEAGTQEDSN
260 270 280 290 300
FRLDEGLATV MELLQDHELL CIYWTKYYTL QHPVIERFVR RQLKGERPII
310 320 330 340 350
LDPADPTHNV AQGYRWDIVA QRASQCLKQD CCYDDRDAPV PSWTVKRAPD
360 370 380 390 400
IQVTVQQWGH PDLILWVNPY EPIKKLKEKI RLSRGYSGLQ RLSFQEPGGQ
410 420 430 440 450
RQLIRSQCSL AYYGIFCDTQ ICLLDTISPE IQVFVKNPDG GSHAYAIHPL
460 470 480 490 500
DFVLSLKQQI EDRQGLQSQE QQLEFQGRVL EDWFDFKSYG IQDSITIILS
510
RKREGKAPSA PS
Length:512
Mass (Da):58,968
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0A57272139AB0BFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti350D → Y in AAP55510 (PubMed:17024523).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY227756 mRNA Translation: AAP55510.1
CH473973 Genomic DNA Translation: EDM13919.1

NCBI Reference Sequences

More...
RefSeqi
NP_001009681.1, NM_001009681.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000001570; ENSRNOP00000001570; ENSRNOG00000001187

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
304545

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:304545

UCSC genome browser

More...
UCSCi
RGD:1308586, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY227756 mRNA Translation: AAP55510.1
CH473973 Genomic DNA Translation: EDM13919.1
RefSeqiNP_001009681.1, NM_001009681.1

3D structure databases

SMRiG3V645
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001570

PTM databases

iPTMnetiG3V645
PhosphoSitePlusiG3V645

Proteomic databases

PaxDbiG3V645
PRIDEiG3V645

Genome annotation databases

EnsembliENSRNOT00000001570; ENSRNOP00000001570; ENSRNOG00000001187
GeneIDi304545
KEGGirno:304545
UCSCiRGD:1308586, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
8638
RGDi1308586, Oasl

Phylogenomic databases

eggNOGiKOG0001, Eukaryota
GeneTreeiENSGT00510000046406
HOGENOMiCLU_040930_1_0_1
InParanoidiG3V645
OMAiQRACQCL
OrthoDBi611234at2759
PhylomeDBiG3V645
TreeFamiTF329749

Miscellaneous databases

Protein Ontology

More...
PROi
PR:G3V645

Gene expression databases

BgeeiENSRNOG00000001187, Expressed in stomach and 22 other tissues
GenevisibleiG3V645, RN

Family and domain databases

CDDicd05400, NT_2-5OAS_ClassI-CCAase, 1 hit
Gene3Di3.30.460.10, 1 hit
InterProiView protein in InterPro
IPR018952, 2-5-oligoAdlate_synth_1_dom2/C
IPR026774, 2-5A_synthase
IPR006117, 2-5OAS_C_CS
IPR006116, NT_2-5OAS_ClassI-CCAase
IPR043519, NT_sf
IPR000626, Ubiquitin-like_dom
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR11258, PTHR11258, 1 hit
PfamiView protein in Pfam
PF10421, OAS1_C, 1 hit
PF00240, ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213, UBQ, 2 hits
SUPFAMiSSF54236, SSF54236, 2 hits
SSF81301, SSF81301, 1 hit
PROSITEiView protein in PROSITE
PS00833, 25A_SYNTH_2, 1 hit
PS50152, 25A_SYNTH_3, 1 hit
PS50053, UBIQUITIN_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiOASL1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V645
Secondary accession number(s): Q5MYW3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: November 16, 2011
Last modified: September 29, 2021
This is version 62 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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