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UniProtKB - G3V612 (G3V612_RAT)
Protein
Submitted name:
Oligodendrocyte transcription factor 2
Gene
Olig2
Organism
Rattus norvegicus (Rat)
Status
Functioni
GO - Molecular functioni
- DNA-binding transcription factor activity Source: RGD
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: RGD
- HMG box domain binding Source: RGD
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- sequence-specific double-stranded DNA binding Source: RGD
GO - Biological processi
- myelination Source: RGD
- negative regulation of neuron differentiation Source: RGD
- negative regulation of transcription by RNA polymerase II Source: RGD
- nervous system development Source: RGD
- neuron differentiation Source: GO_Central
- neuron fate commitment Source: RGD
- oligodendrocyte differentiation Source: RGD
- positive regulation of oligodendrocyte differentiation Source: RGD
- regulation of transcription, DNA-templated Source: RGD
- regulation of transcription by RNA polymerase II Source: GO_Central
- spinal cord motor neuron differentiation Source: RGD
- spinal cord oligodendrocyte cell differentiation Source: RGD
- spinal cord oligodendrocyte cell fate specification Source: RGD
- thalamus development Source: RGD
Names & Taxonomyi
Protein namesi | Submitted name: Oligodendrocyte transcription factor 2Submitted name: RCG58659Imported |
Gene namesi | Name:Olig2Imported ORF Names:rCG_58659Imported |
Organismi | Rattus norvegicus (Rat)Imported |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1307098, Olig2 |
Subcellular locationi
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000028658, Expressed in brain and 5 other tissues |
Interactioni
Binary interactionsi
G3V612
With | #Exp. | IntAct |
---|---|---|
Smarca4 [Q8K1P7] | 2 | EBI-6676662,EBI-689301 |
GO - Molecular functioni
- HMG box domain binding Source: RGD
- identical protein binding Source: RGD
- protein dimerization activity Source: InterPro
Protein-protein interaction databases
IntActi | G3V612, 1 interactor |
STRINGi | 10116.ENSRNOP00000000325 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 108 – 162 | BHLHInterPro annotationAdd BLAST | 55 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 106 | DisorderedSequence analysisAdd BLAST | 106 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 28 – 49 | Polar residuesSequence analysisAdd BLAST | 22 | |
Compositional biasi | 74 – 95 | Polar residuesSequence analysisAdd BLAST | 22 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000161651 |
HOGENOMi | CLU_065376_1_0_1 |
OMAi | PVHHPIL |
OrthoDBi | 1290623at2759 |
TreeFami | TF322733 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032658, Olig2 |
PANTHERi | PTHR19290:SF32, PTHR19290:SF32, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
G3V612-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDSDASLVSS RPSSPEPDDL FLPARSKGGS SSGFTGGTVS SSTPSDCPPE
60 70 80 90 100
LSSELRGAMG TAGAHPGDKL GGGGFKSSSS STSSSTSSAA TSSTKKDKKQ
110 120 130 140 150
MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA
160 170 180 190 200
TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSTPLPT
210 220 230 240 250
ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLSS
260 270 280 290 300
VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG GSGGFQHWGG MPCPCSMCQV
310 320
PPPHHHVSAM GAGTLPRLTS DAK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473989 Genomic DNA Translation: EDM10712.1 |
RefSeqi | NP_001094027.1, NM_001100557.1 |
Genome annotation databases
Ensembli | ENSRNOT00000000325.7; ENSRNOP00000000325.4; ENSRNOG00000028658.6 |
GeneIDi | 304103 |
KEGGi | rno:304103 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH473989 Genomic DNA Translation: EDM10712.1 |
RefSeqi | NP_001094027.1, NM_001100557.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | G3V612, 1 interactor |
STRINGi | 10116.ENSRNOP00000000325 |
Genome annotation databases
Ensembli | ENSRNOT00000000325.7; ENSRNOP00000000325.4; ENSRNOG00000028658.6 |
GeneIDi | 304103 |
KEGGi | rno:304103 |
Organism-specific databases
CTDi | 10215 |
RGDi | 1307098, Olig2 |
Phylogenomic databases
eggNOGi | KOG3898, Eukaryota |
GeneTreei | ENSGT00940000161651 |
HOGENOMi | CLU_065376_1_0_1 |
OMAi | PVHHPIL |
OrthoDBi | 1290623at2759 |
TreeFami | TF322733 |
Gene expression databases
Bgeei | ENSRNOG00000028658, Expressed in brain and 5 other tissues |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR036638, HLH_DNA-bd_sf IPR032658, Olig2 |
PANTHERi | PTHR19290:SF32, PTHR19290:SF32, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V612_RAT | |
Accessioni | G3V612Primary (citable) accession number: G3V612 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | May 25, 2022 | |
This is version 83 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |