Olig2

Functionⁱ

GO - Molecular functionⁱ

HMG box domain binding Source: Ensembl
protein homodimerization activity Source: Ensembl
transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

myelination Source: Ensembl
negative regulation of neuron differentiation Source: Ensembl
negative regulation of transcription by RNA polymerase II Source: Ensembl
neuron fate commitment Source: Ensembl
positive regulation of oligodendrocyte differentiation Source: Ensembl
spinal cord motor neuron differentiation Source: Ensembl
spinal cord oligodendrocyte cell fate specification Source: Ensembl
thalamus development Source: Ensembl

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Submitted name: Oligodendrocyte transcription factor 2Imported Submitted name: RCG58659Imported
Gene namesⁱ	Name:Olig2Imported ORF Names:rCG_58659Imported
Organismⁱ	Rattus norvegicus (Rat)Imported
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 11

Organism-specific databases

Rat genome database More...RGDⁱ	1307098 Olig2

RGDⁱ

1307098 Olig2

Subcellular locationⁱ

GO - Cellular component

PTM / Processingⁱ

Proteomic databases

PRIDEⁱ	G3V612

PRIDEⁱ

G3V612

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000028658 Expressed in 1 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000028658 Expressed in 1 organ(s), highest expression level in brain

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Smarca4	Q8K1P7	2	EBI-6676662,EBI-689301

With

Entry

#Exp.

IntAct

Notes

Smarca4

Q8K1P7

2

EBI-6676662,EBI-689301

GO - Molecular functionⁱ

HMG box domain binding Source: Ensembl
protein homodimerization activity Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	G3V612, 1 interactor
STRINGⁱ	10116.ENSRNOP00000000325

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	108 – 162	BHLHInterPro annotationAdd BLAST		55

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063239
KEGG Orthology (KO) More...KOⁱ	K09085
OMAⁱ	PSACGTM
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G129L
TreeFamⁱ	TF322733

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032658 Olig2
PANTHERⁱ	PTHR19290:SF32 PTHR19290:SF32, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

G3V612-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDSDASLVSS RPSSPEPDDL FLPARSKGGS SSGFTGGTVS SSTPSDCPPE 
        60         70         80         90        100
LSSELRGAMG TAGAHPGDKL GGGGFKSSSS STSSSTSSAA TSSTKKDKKQ 
       110        120        130        140        150
MTEPELQQLR LKINSRERKR MHDLNIAMDG LREVMPYAHG PSVRKLSKIA 
       160        170        180        190        200
TLLLARNYIL MLTNSLEEMK RLVSEIYGGH HAGFHPSACG GLAHSTPLPT 
       210        220        230        240        250
ATAHPAAAAH AAHHPAVHHP ILPPAAAAAA AAAAAAAVSS ASLPGSGLSS 
       260        270        280        290        300
VGSIRPPHGL LKSPSAAAAA PLGGGGGGSG GSGGFQHWGG MPCPCSMCQV 
       310        320 
PPPHHHVSAM GAGTLPRLTS DAK

Length:323

Mass (Da):32,451

Last modified:November 16, 2011 - v1

Checksum:ⁱED9E478C0508C18E

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC112633 Genomic DNA No translation available. CH473989 Genomic DNA Translation: EDM10712.1
NCBI Reference Sequences More...RefSeqⁱ	NP_001094027.1, NM_001100557.1
UniGeneⁱ	Rn.22121

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000325; ENSRNOP00000000325; ENSRNOG00000028658
GeneIDⁱ	304103
KEGGⁱ	rno:304103

Protein	Similar proteins		Species	Score	Length	Source
G3V612	Oligodendrocyte transcription factor 2		MOUSE		323	UniRef90_Q9EQW6
Oligodendrocyte transcription factor 2 (Fragment)		RAT		27
Oligodendrocyte lineage transcription factor 2 (Predicted)		CALJA		323
Uncharacterized protein		MACFA		323
LOW QUALITY PROTEIN: oligodendrocyte transcription factor 2		NEOSC		323
+50

Protein	Similar proteins		Species	Score	Length	Source
G3V612	Oligodendrocyte transcription factor 2		MOUSE		323	UniRef50_Q9EQW6
Oligodendrocyte transcription factor 2 (Fragment)		RAT		27
Uncharacterized protein		ICTTR		323
LOW QUALITY PROTEIN: oligodendrocyte transcription factor 2		NEOSC		323
oligodendrocyte transcription factor 2		PHYCD		323
+87

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AC112633 Genomic DNA No translation available. CH473989 Genomic DNA Translation: EDM10712.1
RefSeqⁱ	NP_001094027.1, NM_001100557.1
UniGeneⁱ	Rn.22121

3D structure databases

ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	G3V612, 1 interactor
STRINGⁱ	10116.ENSRNOP00000000325

Proteomic databases

PRIDEⁱ	G3V612

PRIDEⁱ

G3V612

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000000325; ENSRNOP00000000325; ENSRNOG00000028658
GeneIDⁱ	304103
KEGGⁱ	rno:304103

Organism-specific databases

CTDⁱ	10215
RGDⁱ	1307098 Olig2

Phylogenomic databases

eggNOGⁱ	KOG3898 Eukaryota ENOG4111U26 LUCA
GeneTreeⁱ	ENSGT00530000063239
KOⁱ	K09085
OMAⁱ	PSACGTM
OrthoDBⁱ	EOG091G129L
TreeFamⁱ	TF322733

Gene expression databases

Bgeeⁱ	ENSRNOG00000028658 Expressed in 1 organ(s), highest expression level in brain

Bgeeⁱ

ENSRNOG00000028658 Expressed in 1 organ(s), highest expression level in brain

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR036638 HLH_DNA-bd_sf IPR032658 Olig2
PANTHERⁱ	PTHR19290:SF32 PTHR19290:SF32, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3V612_RAT
Accessionⁱ	G3V612Primary (citable) accession number: G3V612
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	November 7, 2018
	This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3V612 (G3V612_RAT)

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Oligodendrocyte transcription factor 2

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ