UniProtKB - G3V5L0 (G3V5L0_HUMAN)
Protein
Submitted name:
Serine hydroxymethyltransferase, mitochondrial
Gene
SHMT2
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- glycine hydroxymethyltransferase activity Source: InterPro
- pyridoxal phosphate binding Source: InterPro
GO - Biological processi
- glycine biosynthetic process from serine Source: InterPro
- tetrahydrofolate interconversion Source: InterPro
Names & Taxonomyi
Protein namesi | Submitted name: Serine hydroxymethyltransferase, mitochondrialImported |
Gene namesi | Name:SHMT2Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10852 SHMT2 |
Subcellular locationi
Cytoskeleton
- microtubule cytoskeleton Source: HPA
Mitochondrion
- mitochondrion Source: HPA
PTM / Processingi
Proteomic databases
jPOSTi | G3V5L0 |
MaxQBi | G3V5L0 |
PeptideAtlasi | G3V5L0 |
PRIDEi | G3V5L0 |
ProteomicsDBi | 33555 |
Expressioni
Gene expression databases
Bgeei | ENSG00000182199 Expressed in 231 organ(s), highest expression level in thoracic mammary gland |
ExpressionAtlasi | G3V5L0 baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 215 | SHMTInterPro annotationAdd BLAST | 188 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 31 | DisorderedSequence analysisAdd BLAST | 31 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 30 | PolarSequence analysisAdd BLAST | 30 |
Phylogenomic databases
eggNOGi | KOG2467 Eukaryota COG0112 LUCA |
GeneTreei | ENSGT00390000002762 |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major IPR001085 Ser_HO-MeTrfase IPR039429 SHMT-like_dom |
PANTHERi | PTHR11680 PTHR11680, 1 hit |
Pfami | View protein in Pfam PF00464 SHMT, 1 hit |
SUPFAMi | SSF53383 SSF53383, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 14 potential isoforms that are computationally mapped.Show allAlign All
G3V5L0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAIRAQHSNA AQTQTGEANR GWTGQESLSD SDPEMWELLQ REKDRQCRGL
60 70 80 90 100
ELIASENFCS RAALEALGSC LNNKYSEGYP GKRYYGGAEV VDEIELLCQR
110 120 130 140 150
RALEAFDLDP AQWGVNVQPY SGSPANLAVY TALLQPHDRI MGLDLPDGGH
160 170 180 190 200
LTHGYMSDVK RISATSIFFE SMPYKLNPKT GLIDYNQLAL TARLFRPRLI
210
IAGTSAYARL IDYAR
Computationally mapped potential isoform sequencesi
There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP34897 | GLYM_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 504 | Annotation score: | ||
G3V241 | G3V241_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 142 | Annotation score: | ||
G3V2W0 | G3V2W0_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 160 | Annotation score: | ||
G3V4T0 | G3V4T0_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 149 | Annotation score: | ||
G3V4X0 | G3V4X0_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 159 | Annotation score: | ||
G3V3Y8 | G3V3Y8_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 147 | Annotation score: | ||
G3V4W5 | G3V4W5_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 237 | Annotation score: | ||
G3V540 | G3V540_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 192 | Annotation score: | ||
G3V2E4 | G3V2E4_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 171 | Annotation score: | ||
G3V2Y4 | G3V2Y4_HUMAN | Serine hydroxymethyltransferase, mi... | SHMT2 | 234 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 215 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC137834 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000554975; ENSP00000452404; ENSG00000182199 |
UCSCi | uc058pug.1 human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC137834 Genomic DNA No translation available. |
3D structure databases
SMRi | G3V5L0 |
ModBasei | Search... |
Proteomic databases
jPOSTi | G3V5L0 |
MaxQBi | G3V5L0 |
PeptideAtlasi | G3V5L0 |
PRIDEi | G3V5L0 |
ProteomicsDBi | 33555 |
Genome annotation databases
Ensembli | ENST00000554975; ENSP00000452404; ENSG00000182199 |
UCSCi | uc058pug.1 human |
Organism-specific databases
HGNCi | HGNC:10852 SHMT2 |
OpenTargetsi | ENSG00000182199 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2467 Eukaryota COG0112 LUCA |
GeneTreei | ENSGT00390000002762 |
Miscellaneous databases
ChiTaRSi | SHMT2 human |
Gene expression databases
Bgeei | ENSG00000182199 Expressed in 231 organ(s), highest expression level in thoracic mammary gland |
ExpressionAtlasi | G3V5L0 baseline and differential |
Family and domain databases
Gene3Di | 3.40.640.10, 1 hit 3.90.1150.10, 1 hit |
InterProi | View protein in InterPro IPR015424 PyrdxlP-dep_Trfase IPR015422 PyrdxlP-dep_Trfase_dom1 IPR015421 PyrdxlP-dep_Trfase_major IPR001085 Ser_HO-MeTrfase IPR039429 SHMT-like_dom |
PANTHERi | PTHR11680 PTHR11680, 1 hit |
Pfami | View protein in Pfam PF00464 SHMT, 1 hit |
SUPFAMi | SSF53383 SSF53383, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V5L0_HUMAN | |
Accessioni | G3V5L0Primary (citable) accession number: G3V5L0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | July 31, 2019 | |
This is version 52 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |