UniProtKB - G3V595 (G3V595_HUMAN)
Protein
Submitted name:
Alpha-1-antichymotrypsin
Gene
SERPINA3
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: Alpha-1-antichymotrypsinImported |
Gene namesi | Name:SERPINA3Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196136.16 |
HGNCi | HGNC:16, SERPINA3 |
Subcellular locationi
Extracellular region or secreted
- extracellular space Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_5003457330 | 24 – 305 | Sequence analysisAdd BLAST | 282 |
Proteomic databases
EPDi | G3V595 |
MaxQBi | G3V595 |
PeptideAtlasi | G3V595 |
PRIDEi | G3V595 |
ProteomicsDBi | 33460 |
Expressioni
Gene expression databases
Bgeei | ENSG00000196136, Expressed in liver and 111 other tissues |
ExpressionAtlasi | G3V595, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 58 – 305 | SERPINInterPro annotationAdd BLAST | 248 |
Sequence similaritiesi
Belongs to the serpin family.UniRule annotation
Keywords - Domaini
SignalSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154392 |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
G3V595-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MERMLPLLAL GLLAAGFCPA VLCHPNSPLD EENLTQENQD RGTHVDLGLA
60 70 80 90 100
SANVDFAFSL YKQLVLKAPD KNVIFSPLSI STALAFLSLG AHNTTLTEIL
110 120 130 140 150
KGLKFNLTET SEAEIHQSFQ HLLRTLNQSS DELQLSMGNA MFVKEQLSLL
160 170 180 190 200
DRFTEDAKRL YGSEAFATDF QDSAAAKKLI NDYVKNGTRG KITDLIKDLD
210 220 230 240 250
SQTMMVLVNY IFFKAKWEMP FDPQDTHQSR FYLSKKKWVM VPMMSLHHLT
260 270 280 290 300
IPYFRDEELS CTVVELKYTG NASALFILPD QDKMEEVEAM LLPETLKRWR
DSLEF
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP01011 | AACT_HUMAN | Alpha-1-antichymotrypsin | SERPINA3 AACT, GIG24, GIG25 | 423 | Annotation score: | ||
G3V3A0 | G3V3A0_HUMAN | Alpha-1-antichymotrypsin | SERPINA3 hCG_2039549 | 205 | Annotation score: | ||
A0A087WY93 | A0A087WY93_HUMAN | Alpha-1-antichymotrypsin | SERPINA3 | 46 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 305 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049839 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000555820; ENSP00000452246; ENSG00000196136 |
UCSCi | uc059etl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL049839 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | G3V595 |
MaxQBi | G3V595 |
PeptideAtlasi | G3V595 |
PRIDEi | G3V595 |
ProteomicsDBi | 33460 |
Protocols and materials databases
Antibodypediai | 765, 546 antibodies |
Genome annotation databases
Ensembli | ENST00000555820; ENSP00000452246; ENSG00000196136 |
UCSCi | uc059etl.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000196136.16 |
HGNCi | HGNC:16, SERPINA3 |
OpenTargetsi | ENSG00000196136 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000154392 |
Miscellaneous databases
ChiTaRSi | SERPINA3, human |
Gene expression databases
Bgeei | ENSG00000196136, Expressed in liver and 111 other tissues |
ExpressionAtlasi | G3V595, baseline and differential |
Family and domain databases
Gene3Di | 2.30.39.10, 1 hit 3.30.497.10, 1 hit |
InterProi | View protein in InterPro IPR023796, Serpin_dom IPR000215, Serpin_fam IPR036186, Serpin_sf IPR042178, Serpin_sf_1 IPR042185, Serpin_sf_2 |
PANTHERi | PTHR11461, PTHR11461, 1 hit |
Pfami | View protein in Pfam PF00079, Serpin, 1 hit |
SMARTi | View protein in SMART SM00093, SERPIN, 1 hit |
SUPFAMi | SSF56574, SSF56574, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V595_HUMAN | |
Accessioni | G3V595Primary (citable) accession number: G3V595 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | October 29, 2014 | |
Last modified: | August 12, 2020 | |
This is version 59 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |