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Protein
Submitted name:

Unconventional myosin-Ia

Gene

MYO1A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionActin-bindingPROSITE-ProRule annotation, Motor protein, MyosinPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Unconventional myosin-IaImported
Gene namesi
Name:MYO1AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000166866.12
HGNCiHGNC:7595 MYO1A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000166866

PTM / Processingi

Proteomic databases

PeptideAtlasiG3V587
PRIDEiG3V587

Expressioni

Gene expression databases

BgeeiENSG00000166866 Expressed in 101 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiG3V587 baseline and differential

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliG3V587
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 73Myosin motorInterPro annotationAdd BLAST73

Sequence similaritiesi

Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810

Family and domain databases

InterProiView protein in InterPro
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3V587-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVGLNSEEVE RALCSRTMET AKEKVVTALN VMQAQYARDA LAKNIYSRLF
60 70
DWIVNRINES IKVGIGEKKK VMG
Length:73
Mass (Da):8,247
Last modified:October 5, 2016 - v8
Checksum:i0A997F8FC0D81F3D
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UBC5MYO1A_HUMAN
Unconventional myosin-Ia
MYO1A MYHL
1,043Annotation score:
G3V342G3V342_HUMAN
Unconventional myosin-Ia
MYO1A
688Annotation score:
C9JU63C9JU63_HUMAN
Unconventional myosin-Ia
MYO1A
96Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei73Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026120 Genomic DNA No translation available.
KF455654 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000492945; ENSP00000452229; ENSG00000166866
UCSCiuc058prz.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC026120 Genomic DNA No translation available.
KF455654 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliG3V587
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiG3V587
PRIDEiG3V587

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000492945; ENSP00000452229; ENSG00000166866
UCSCiuc058prz.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000166866.12
HGNCiHGNC:7595 MYO1A
OpenTargetsiENSG00000166866
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0164 Eukaryota
COG5022 LUCA
GeneTreeiENSGT00930000150810

Gene expression databases

BgeeiENSG00000166866 Expressed in 101 organ(s), highest expression level in small intestine Peyer's patch
ExpressionAtlasiG3V587 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR001609 Myosin_head_motor_dom
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00063 Myosin_head, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS51456 MYOSIN_MOTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3V587_HUMAN
AccessioniPrimary (citable) accession number: G3V587
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: October 5, 2016
Last modified: November 7, 2018
This is version 55 of the entry and version 8 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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