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Protein
Submitted name:

Tyrosyl-DNA phosphodiesterase 1

Gene

TDP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosyl-DNA phosphodiesterase 1Imported
Gene namesi
Name:TDP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000042088.13
HGNCiHGNC:18884 TDP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000042088

PTM / Processingi

Proteomic databases

MaxQBiG3V554
PeptideAtlasiG3V554
PRIDEiG3V554

Expressioni

Gene expression databases

BgeeiENSG00000042088 Expressed in 170 organ(s), highest expression level in oocyte
ExpressionAtlasiG3V554 baseline and differential

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2031 Eukaryota
ENOG410XQPZ LUCA
GeneTreeiENSGT00390000002211

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.iShow all

G3V554-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE
60 70 80 90 100
AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM
110 120 130 140 150
PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE
160
GQDIWDMLDK G
Length:161
Mass (Da):17,913
Last modified:November 16, 2011 - v1
Checksum:i077F8A69845428E7
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NUW8TYDP1_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
608Annotation score:
G3V2F4G3V2F4_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
578Annotation score:
E7EPD8E7EPD8_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
589Annotation score:
G3V2U6G3V2U6_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
279Annotation score:
G3V5B8G3V5B8_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
151Annotation score:
G3V3Q0G3V3Q0_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
146Annotation score:
G3V5F9G3V5F9_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
147Annotation score:
H0YJ44H0YJ44_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
281Annotation score:
G3V2J6G3V2J6_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
219Annotation score:
G3V5H9G3V5H9_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
259Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei161Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137128 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000556498; ENSP00000452183; ENSG00000042088
UCSCiuc059efs.1 human

Similar proteinsi

Entry informationi

Entry nameiG3V554_HUMAN
AccessioniPrimary (citable) accession number: G3V554
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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