UniProtKB - G3V4Z4 (G3V4Z4_HUMAN)
Protein
Submitted name:
Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial
Gene
ALDH6A1
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- 2-methyl-3-oxopropanoate + CoA + H2O + NAD+ = H+ + hydrogencarbonate + NADH + propanoyl-CoAARBA annotationEC:1.2.1.27ARBA annotation
- EC:1.2.1.18ARBA annotation
- EC:1.2.1.18ARBA annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 34 | PROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- malonate-semialdehyde dehydrogenase (acetylating) activity Source: UniProtKB-EC
- methylmalonate-semialdehyde dehydrogenase (acylating) activity Source: UniProtKB-EC
Keywordsi
Molecular function | OxidoreductaseARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrialImported |
Gene namesi | Name:ALDH6A1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7179, ALDH6A1 |
VEuPathDBi | HostDB:ENSG00000119711.12 |
Subcellular locationi
Mitochondrion
- mitochondrion Source: HPA
Nucleus
- nucleoplasm Source: HPA
PTM / Processingi
Proteomic databases
MaxQBi | G3V4Z4 |
PeptideAtlasi | G3V4Z4 |
PRIDEi | G3V4Z4 |
ProteomicsDBi | 33374 |
Expressioni
Gene expression databases
Bgeei | ENSG00000119711, Expressed in cortex of kidney and 256 other tissues |
ExpressionAtlasi | G3V4Z4, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 229 | AldedhInterPro annotationAdd BLAST | 229 |
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00940000156110 |
HOGENOMi | CLU_005391_1_10_1 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010061, MeMal-semiAld_DH |
PANTHERi | PTHR43866, PTHR43866, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
G3V4Z4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGAKNHGVVM PDANKENTLN QLVGAAFGAA GQRCMALSTA VLVGEAKKWL
60 70 80 90 100
PELVEHAKNL RVNAGDQPGA DLGPLITPQA KERVCNLIDS GTKEGASILL
110 120 130 140 150
DGRKIKVKGY ENGNFVGPTI ISNVKPNMTC YKEEIFGPVL VVLETETLDE
160 170 180 190 200
AIQIVNNNPY GNGTAIFTTN GATARKYAHL VDVGQVGVNV PIPVPLPMFS
210 220 230 240 250
FTGSRSSFRG DTNFYGKQGI QFYTQLKTIT SQWKEEDATL SSPAVVMPTM
GR
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketQ02252 | MMSA_HUMAN | Methylmalonate-semialdehyde dehydro... | ALDH6A1 MMSDH | 535 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005484 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000555126; ENSP00000452081; ENSG00000119711 |
UCSCi | uc059dgw.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005484 Genomic DNA No translation available. |
3D structure databases
SMRi | G3V4Z4 |
ModBasei | Search... |
Proteomic databases
MaxQBi | G3V4Z4 |
PeptideAtlasi | G3V4Z4 |
PRIDEi | G3V4Z4 |
ProteomicsDBi | 33374 |
Protocols and materials databases
Antibodypediai | 25547, 487 antibodies |
Genome annotation databases
Ensembli | ENST00000555126; ENSP00000452081; ENSG00000119711 |
UCSCi | uc059dgw.1, human |
Organism-specific databases
HGNCi | HGNC:7179, ALDH6A1 |
OpenTargetsi | ENSG00000119711 |
VEuPathDBi | HostDB:ENSG00000119711.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156110 |
HOGENOMi | CLU_005391_1_10_1 |
Miscellaneous databases
ChiTaRSi | ALDH6A1, human |
Gene expression databases
Bgeei | ENSG00000119711, Expressed in cortex of kidney and 256 other tissues |
ExpressionAtlasi | G3V4Z4, baseline and differential |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010061, MeMal-semiAld_DH |
PANTHERi | PTHR43866, PTHR43866, 1 hit |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V4Z4_HUMAN | |
Accessioni | G3V4Z4Primary (citable) accession number: G3V4Z4 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |