UniProtKB - G3V4V5 (G3V4V5_HUMAN)
Protein
Submitted name:
E3 ubiquitin-protein ligase HECTD1
Gene
HECTD1
Organism
Homo sapiens (Human)
Status
Names & Taxonomyi
Protein namesi | Submitted name: E3 ubiquitin-protein ligase HECTD1Imported |
Gene namesi | Name:HECTD1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20157, HECTD1 |
VEuPathDBi | HostDB:ENSG00000092148.12 |
Expressioni
Gene expression databases
Bgeei | ENSG00000092148, Expressed in gastrocnemius and 214 other tissues |
ExpressionAtlasi | G3V4V5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 361 – 483 | ANK_REP_REGIONInterPro annotationAdd BLAST | 123 | |
Repeati | 395 – 427 | ANKPROSITE-ProRule annotationAdd BLAST | 33 | |
Repeati | 426 – 458 | ANKPROSITE-ProRule annotationAdd BLAST | 33 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 246 – 269 | DisorderedSequence analysisAdd BLAST | 24 | |
Regioni | 489 – 513 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 627 – 657 | DisorderedSequence analysisAdd BLAST | 31 | |
Regioni | 707 – 748 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 252 – 269 | PolarSequence analysisAdd BLAST | 18 | |
Compositional biasi | 489 – 512 | PolyampholyteSequence analysisAdd BLAST | 24 | |
Compositional biasi | 733 – 748 | PolarSequence analysisAdd BLAST | 16 |
Keywords - Domaini
ANK repeatPROSITE-ProRule annotationARBA annotation, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000156572 |
HOGENOMi | CLU_014262_0_0_1 |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
G3V4V5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MADVDPDTLL EWLQMGQGDE RDMQLIALEQ LCMLLLMSDN VDRCFETCPP
60 70 80 90 100
RTFLPALCKI FLDESAPDNV LEVTARAITY YLDVSAECTR RIVGVDGAIK
110 120 130 140 150
ALCNRLVVVE LNNRTSRDLA EQCVKVLELI CTRESGAVFE AGGLNCVLTF
160 170 180 190 200
IRDSGHLVHK DTLHSAMAVV SRLCGKMEPQ DSSLEICVES LSSLLKHEDH
210 220 230 240 250
QVSDGALRCF ASLADRFTRR GVDPAPLAKH GLTEELLSRM AAAGGTVSGP
260 270 280 290 300
SSACKPGRST TGAPSTTADS KLSNQVSTIV SLLSTLCRGS PVVTHDLLRS
310 320 330 340 350
ELPDSIESAL QGDERCVLDT MRLVDLLLVL LFEGRKALPK SSAGSTGRIP
360 370 380 390 400
GLRRLDSSGE RSHRQLIDCI RSKDTDALID AIDTGAFEVN FMDDVGQTLL
410 420 430 440 450
NWASAFGTQE MVEFLCERGA DVNRGQRSSS LHYAACFGRP QVAKTLLRHG
460 470 480 490 500
ANPDLRDEDG KTPLDKARER GHSEVVAILQ SPGDWMCPVN KGDDKKKKDT
510 520 530 540 550
NKDEEECNEP KGDPEMAPIY LKRLLPVFAQ TFQQTMLPSI RKASLALIRK
560 570 580 590 600
MIHFCSEALL KEVCDSDVGH NLPTILVEIT ATVLDQEDDD DGHLLALQII
610 620 630 640 650
RDLVDKGGDI FLDQLARLGV ISKVSTLAGP SSDDENEEES KPEKEDEPQE
660 670 680 690 700
DAKELQQGKP YHWRDWSIIR GRDCLYIWSD AAALELSNGS NGWFRFILDG
710 720 730 740 750
KLATMYSSGS PEGGSDSSES RSEFLEKLQR ARGQVKPSTS SQPILSAPGP
760 770 780 790 800
TKLTVGNWSL TCLKEGEIAI HNSDGQQATI LKEDLPGFVF ESNRGTKHSF
810 820 830 840 850
TAETSLGSEF VTGWTGKRGR KLKSKLEKTK QKVRTMARDL YDDHFKAVES
860 870 880 890 900
MPRGVVVTLR NIATQLESSW ELHTNRQCIE SENTWRDLMK TALENLIVLL
910 920
KDENTISPYE MCSSGLVQAL LTVLNN
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9ULT8 | HECD1_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 KIAA1131 | 2,610 | Annotation score: | ||
A0A087X2H1 | A0A087X2H1_HUMAN | HECT-type E3 ubiquitin transferase | HECTD1 | 2,614 | Annotation score: | ||
H0YJP0 | H0YJP0_HUMAN | HECT-type E3 ubiquitin transferase | HECTD1 | 1,465 | Annotation score: | ||
H0YJV8 | H0YJV8_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 185 | Annotation score: | ||
H0YJD4 | H0YJD4_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 976 | Annotation score: | ||
A0A087WVU6 | A0A087WVU6_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 212 | Annotation score: | ||
H0YJ72 | H0YJ72_HUMAN | E3 ubiquitin-protein ligase HECTD1 | HECTD1 | 122 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 926 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121808 Genomic DNA No translation available. AL136418 Genomic DNA No translation available. KC877516 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000556224; ENSP00000452015; ENSG00000092148 |
UCSCi | uc059aod.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL121808 Genomic DNA No translation available. AL136418 Genomic DNA No translation available. KC877516 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
EPDi | G3V4V5 |
MaxQBi | G3V4V5 |
PeptideAtlasi | G3V4V5 |
ProteomicsDBi | 33340 |
Protocols and materials databases
Antibodypediai | 5457, 106 antibodies |
Genome annotation databases
Ensembli | ENST00000556224; ENSP00000452015; ENSG00000092148 |
UCSCi | uc059aod.1, human |
Organism-specific databases
HGNCi | HGNC:20157, HECTD1 |
OpenTargetsi | ENSG00000092148 |
VEuPathDBi | HostDB:ENSG00000092148.12 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000156572 |
HOGENOMi | CLU_014262_0_0_1 |
Miscellaneous databases
ChiTaRSi | HECTD1, human |
Gene expression databases
Bgeei | ENSG00000092148, Expressed in gastrocnemius and 214 other tissues |
ExpressionAtlasi | G3V4V5, baseline and differential |
Family and domain databases
Gene3Di | 1.25.10.10, 1 hit 1.25.40.20, 1 hit |
InterProi | View protein in InterPro IPR002110, Ankyrin_rpt IPR020683, Ankyrin_rpt-contain_dom IPR036770, Ankyrin_rpt-contain_sf IPR011989, ARM-like IPR016024, ARM-type_fold |
Pfami | View protein in Pfam PF12796, Ank_2, 1 hit |
SMARTi | View protein in SMART SM00248, ANK, 3 hits |
SUPFAMi | SSF48371, SSF48371, 1 hit SSF48403, SSF48403, 1 hit |
PROSITEi | View protein in PROSITE PS50297, ANK_REP_REGION, 1 hit PS50088, ANK_REPEAT, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V4V5_HUMAN | |
Accessioni | G3V4V5Primary (citable) accession number: G3V4V5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 69 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |