UniProtKB - G3V4U7 (G3V4U7_HUMAN)
Protein
Submitted name:
Lysosomal cobalamin transporter ABCD4
Gene
ABCD4
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ATPase-coupled transmembrane transporter activity Source: InterPro
- ATP binding Source: InterPro
Keywordsi
Biological process | TransportARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Lysosomal cobalamin transporter ABCD4Imported |
Gene namesi | Name:ABCD4Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:68, ABCD4 |
VEuPathDBi | HostDB:ENSG00000119688.20 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSG00000119688, Expressed in left lobe of thyroid gland and 218 other tissues |
ExpressionAtlasi | G3V4U7, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 179 | ABC transmembrane type-1InterPro annotationAdd BLAST | 153 |
Keywords - Domaini
Transmembrane, Transmembrane helixARBA annotationPhylogenomic databases
GeneTreei | ENSGT00950000182955 |
HOGENOMi | CLU_1434037_0_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf |
Pfami | View protein in Pfam PF06472, ABC_membrane_2, 1 hit |
SUPFAMi | SSF90123, SSF90123, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All
G3V4U7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAVAGPAPGA GARPRLDLQF LQRFLQILKV LFPSWSSQNA LMFLTLLCLT
60 70 80 90 100
LLEQFVIYQV GLIPSQYYGV LGNKDLEGFK TLTFLAVMLI VLNSTLKSFD
110 120 130 140 150
QFTCNLLYVS WRKDLTEHLH RLYFRGRAYY TLNVLRDDID NPDQRISQDV
160 170 180 190 200
ERFCRQLSSM ASKLIISPFT LVYYTYQCFQ RFKHMQIRVN AEPAAFYSRH
QHL
Computationally mapped potential isoform sequencesi
There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO14678 | ABCD4_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 PXMP1L | 606 | Annotation score: | ||
H0YJX8 | H0YJX8_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 94 | Annotation score: | ||
H0YJL8 | H0YJL8_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 205 | Annotation score: | ||
H0YJ78 | H0YJ78_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 184 | Annotation score: | ||
H0YCY9 | H0YCY9_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 173 | Annotation score: | ||
G3V3W1 | G3V3W1_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 98 | Annotation score: | ||
H0YJ82 | H0YJ82_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 158 | Annotation score: | ||
E9PI46 | E9PI46_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 56 | Annotation score: | ||
E9PPB6 | E9PPB6_HUMAN | Lysosomal cobalamin transporter ABC... | ABCD4 | 39 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005519 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000557588; ENSP00000451993; ENSG00000119688 |
UCSCi | uc059dhx.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC005519 Genomic DNA No translation available. |
3D structure databases
SMRi | G3V4U7 |
ModBasei | Search... |
Proteomic databases
PeptideAtlasi | G3V4U7 |
PRIDEi | G3V4U7 |
ProteomicsDBi | 33335 |
Protocols and materials databases
Antibodypediai | 184, 226 antibodies |
Genome annotation databases
Ensembli | ENST00000557588; ENSP00000451993; ENSG00000119688 |
UCSCi | uc059dhx.1, human |
Organism-specific databases
HGNCi | HGNC:68, ABCD4 |
OpenTargetsi | ENSG00000119688 |
VEuPathDBi | HostDB:ENSG00000119688.20 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182955 |
HOGENOMi | CLU_1434037_0_0_1 |
Miscellaneous databases
ChiTaRSi | ABCD4, human |
Gene expression databases
Bgeei | ENSG00000119688, Expressed in left lobe of thyroid gland and 218 other tissues |
ExpressionAtlasi | G3V4U7, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011527, ABC1_TM_dom IPR036640, ABC1_TM_sf |
Pfami | View protein in Pfam PF06472, ABC_membrane_2, 1 hit |
SUPFAMi | SSF90123, SSF90123, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V4U7_HUMAN | |
Accessioni | G3V4U7Primary (citable) accession number: G3V4U7 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 49 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |