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UniProtKB - G3V420 (G3V420_HUMAN)
Protein
Protein NDRG2
Gene
NDRG2
Organism
Homo sapiens (Human)
Status
Functioni
Contributes to the regulation of the Wnt signaling pathway. Down-regulates CTNNB1-mediated transcriptional activation of target genes. May be involved in neuron differentiation.
UniRule annotationGO - Biological processi
- cell differentiation Source: UniProtKB-UniRule
- nervous system development Source: UniProtKB-KW
- Wnt signaling pathway Source: UniProtKB-UniRule
Keywordsi
Molecular function | Developmental proteinUniRule annotationARBA annotation |
Biological process | DifferentiationUniRule annotationARBA annotation, NeurogenesisUniRule annotationARBA annotation, Wnt signaling pathwayUniRule annotationARBA annotation |
Protein family/group databases
ESTHERi | human-NDRG2, Ndr_family |
Names & Taxonomyi
Protein namesi | Recommended name: Protein NDRG2UniRule annotationARBA annotation |
Gene namesi | Name:NDRG2 |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:14460, NDRG2 |
VEuPathDBi | HostDB:ENSG00000165795 |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm UniRule annotationARBA annotation
Other locations
- growth cone ARBA annotation
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
CytoplasmUniRule annotationExpressioni
Gene expression databases
Bgeei | ENSG00000165795, Expressed in medial globus pallidus and 240 other tissues |
ExpressionAtlasi | G3V420, baseline and differential |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 29 | DisorderedSequence analysisAdd BLAST | 29 |
Sequence similaritiesi
Phylogenomic databases
GeneTreei | ENSGT00950000182872 |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR004142, NDRG IPR030690, NDRG2 |
PANTHERi | PTHR11034, PTHR11034, 1 hit PTHR11034:SF17, PTHR11034:SF17, 1 hit |
Pfami | View protein in Pfam PF03096, Ndr, 1 hit |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 42 potential isoforms that are computationally mapped.Show allAlign All
G3V420-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MAELQEVQIT EEKPLLPGQT PEAAKTHSVE TPYGSVTFTV YGTPKPKRPA
60 70 80 90 100
ILTYHDVGLN STVSVRGHAG NHSELCAGSC GCPWNGRGSP CVPFGISVPI
SGPACRHD
Computationally mapped potential isoform sequencesi
There are 42 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9UN36 | NDRG2_HUMAN | Protein NDRG2 | NDRG2 KIAA1248, SYLD | 371 | Annotation score: | ||
G3V280 | G3V280_HUMAN | Protein NDRG2 | NDRG2 | 144 | Annotation score: | ||
G3V5A6 | G3V5A6_HUMAN | Protein NDRG2 | NDRG2 | 142 | Annotation score: | ||
G3V383 | G3V383_HUMAN | Protein NDRG2 | NDRG2 | 194 | Annotation score: | ||
G3V3D5 | G3V3D5_HUMAN | Protein NDRG2 | NDRG2 | 149 | Annotation score: | ||
G3V578 | G3V578_HUMAN | Protein NDRG2 | NDRG2 | 284 | Annotation score: | ||
G3V2I9 | G3V2I9_HUMAN | Protein NDRG2 | NDRG2 | 252 | Annotation score: | ||
G3V2T2 | G3V2T2_HUMAN | Protein NDRG2 | NDRG2 | 141 | Annotation score: | ||
G3V3P1 | G3V3P1_HUMAN | Protein NDRG2 | NDRG2 | 148 | Annotation score: | ||
G3V4T9 | G3V4T9_HUMAN | Protein NDRG2 | NDRG2 | 140 | Annotation score: | ||
There are more potential isoformsShow all |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 108 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL161668 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000553563.5; ENSP00000451541.1; ENSG00000165795.25 |
UCSCi | uc058yyj.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL161668 Genomic DNA No translation available. |
3D structure databases
SMRi | G3V420 |
ModBasei | Search... |
Protein family/group databases
ESTHERi | human-NDRG2, Ndr_family |
Proteomic databases
MaxQBi | G3V420 |
PeptideAtlasi | G3V420 |
ProteomicsDBi | 33109 |
Protocols and materials databases
Antibodypediai | 142, 386 antibodies from 38 providers |
Genome annotation databases
Ensembli | ENST00000553563.5; ENSP00000451541.1; ENSG00000165795.25 |
UCSCi | uc058yyj.1, human |
Organism-specific databases
HGNCi | HGNC:14460, NDRG2 |
OpenTargetsi | ENSG00000165795 |
VEuPathDBi | HostDB:ENSG00000165795 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00950000182872 |
Miscellaneous databases
ChiTaRSi | NDRG2, human |
Gene expression databases
Bgeei | ENSG00000165795, Expressed in medial globus pallidus and 240 other tissues |
ExpressionAtlasi | G3V420, baseline and differential |
Family and domain databases
Gene3Di | 3.40.50.1820, 1 hit |
InterProi | View protein in InterPro IPR029058, AB_hydrolase IPR004142, NDRG IPR030690, NDRG2 |
PANTHERi | PTHR11034, PTHR11034, 1 hit PTHR11034:SF17, PTHR11034:SF17, 1 hit |
Pfami | View protein in Pfam PF03096, Ndr, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V420_HUMAN | |
Accessioni | G3V420Primary (citable) accession number: G3V420 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | May 25, 2022 | |
This is version 61 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |