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Protein

Cleavage and polyadenylation specificity factor subunit 2

Gene

CPSF2

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-bindingUniRule annotation
Biological processmRNA processingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Cleavage and polyadenylation specificity factor subunit 2UniRule annotation
Alternative name(s):
Cleavage and polyadenylation specificity factor 100 kDa subunitUniRule annotation
Gene namesi
Name:CPSF2Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000165934.12
HGNCiHGNC:2325 CPSF2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000165934

PTM / Processingi

Proteomic databases

MaxQBiG3V3T7
PeptideAtlasiG3V3T7
PRIDEiG3V3T7

Expressioni

Gene expression databases

BgeeiENSG00000165934 Expressed in 205 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiG3V3T7 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliG3V3T7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 76Lactamase_BInterPro annotationAdd BLAST55

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1135 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144260

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR027075 CPSF2
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR11203:SF5 PTHR11203:SF5, 1 hit
PfamiView protein in Pfam
PF16661 Lactamase_B_6, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3V3T7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSIIKLTTL SGVQEESALC YLLQVDEFRF LLDCGWDEHF SMDIIDSLRK
60 70 80
HVHQIDAVLL SHPDPLHLGA LPYAVGKLGL
Length:80
Mass (Da):8,975
Last modified:November 16, 2011 - v1
Checksum:i400B7E01AD7E6CA3
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9P2I0CPSF2_HUMAN
Cleavage and polyadenylation specif...
CPSF2 CPSF100, KIAA1367
782Annotation score:
G3V5T3G3V5T3_HUMAN
Cleavage and polyadenylation specif...
CPSF2
62Annotation score:
H0YJF4H0YJF4_HUMAN
Cleavage and polyadenylation specif...
CPSF2
269Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei80Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121773 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000553427; ENSP00000451418; ENSG00000165934
UCSCiuc059emu.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL121773 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliG3V3T7
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiG3V3T7
PeptideAtlasiG3V3T7
PRIDEiG3V3T7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000553427; ENSP00000451418; ENSG00000165934
UCSCiuc059emu.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000165934.12
HGNCiHGNC:2325 CPSF2
OpenTargetsiENSG00000165934
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1135 Eukaryota
COG1236 LUCA
GeneTreeiENSGT00910000144260

Miscellaneous databases

ChiTaRSiCPSF2 human

Gene expression databases

BgeeiENSG00000165934 Expressed in 205 organ(s), highest expression level in amniotic fluid
ExpressionAtlasiG3V3T7 baseline and differential

Family and domain databases

Gene3Di3.60.15.10, 1 hit
InterProiView protein in InterPro
IPR027075 CPSF2
IPR001279 Metallo-B-lactamas
IPR036866 RibonucZ/Hydroxyglut_hydro
PANTHERiPTHR11203:SF5 PTHR11203:SF5, 1 hit
PfamiView protein in Pfam
PF16661 Lactamase_B_6, 1 hit
SUPFAMiSSF56281 SSF56281, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3V3T7_HUMAN
AccessioniPrimary (citable) accession number: G3V3T7
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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