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Protein

Protein transport protein SEC23

Gene

SEC23A

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processER-Golgi transportUniRule annotation, Protein transportUniRule annotation, Transport
LigandMetal-bindingUniRule annotation, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein transport protein SEC23UniRule annotation
Gene namesi
Name:SEC23AImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100934.14
HGNCiHGNC:10701 SEC23A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

CytoplasmUniRule annotation, Cytoplasmic vesicleUniRule annotation, Endoplasmic reticulumUniRule annotation, MembraneUniRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100934

PTM / Processingi

Proteomic databases

MaxQBiG3V3G5
PeptideAtlasiG3V3G5
PRIDEiG3V3G5

Expressioni

Gene expression databases

BgeeiENSG00000100934 Expressed in 241 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiG3V3G5 baseline and differential

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini58 – 98zf-Sec23_Sec24InterPro annotationAdd BLAST41

Sequence similaritiesi

Belongs to the SEC23/SEC24 family. SEC23 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916

Family and domain databases

InterProiView protein in InterPro
IPR037364 Sec23
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF82919 SSF82919, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

G3V3G5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTYLEFIQQ NEERDGVRFS WNVWPSSRLE ATRMVVPVAA LFTPLKERPD
60 70 80 90 100
LPPIQYEPVL CSRTTCRAVL NPLCQVDYRA KLWACNFCYQ RNQFPPSYAG
110 120 130 140
ISELNQPAEL LPQFSSIEYV VLRGPQMPLI FLYVVDTCME
Length:140
Mass (Da):16,257
Last modified:November 16, 2011 - v1
Checksum:iE9565F133C986C77
GO

Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q15436SC23A_HUMAN
Protein transport protein Sec23A
SEC23A
765Annotation score:
F5H365F5H365_HUMAN
Protein transport protein SEC23
SEC23A
736Annotation score:
G3V2R6G3V2R6_HUMAN
Protein transport protein SEC23
SEC23A
169Annotation score:
G3V5X8G3V5X8_HUMAN
Protein transport protein SEC23
SEC23A
85Annotation score:
G3V1W4G3V1W4_HUMAN
Protein transport protein SEC23
SEC23A
108Annotation score:
G3V4V1G3V4V1_HUMAN
Protein transport protein SEC23
SEC23A
93Annotation score:
G3V5K1G3V5K1_HUMAN
Protein transport protein SEC23
SEC23A
40Annotation score:
G3V4Q2G3V4Q2_HUMAN
Protein transport protein SEC23
SEC23A
86Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei140Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109628 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000556092; ENSP00000451230; ENSG00000100934
UCSCiuc059azo.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL109628 Genomic DNA No translation available.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

MaxQBiG3V3G5
PeptideAtlasiG3V3G5
PRIDEiG3V3G5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000556092; ENSP00000451230; ENSG00000100934
UCSCiuc059azo.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000100934.14
HGNCiHGNC:10701 SEC23A
OpenTargetsiENSG00000100934
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1986 Eukaryota
COG5047 LUCA
GeneTreeiENSGT00390000006916

Miscellaneous databases

ChiTaRSiSEC23A human

Gene expression databases

BgeeiENSG00000100934 Expressed in 241 organ(s), highest expression level in jejunal mucosa
ExpressionAtlasiG3V3G5 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR037364 Sec23
IPR006895 Znf_Sec23_Sec24
IPR036174 Znf_Sec23_Sec24_sf
PANTHERiPTHR11141 PTHR11141, 1 hit
PfamiView protein in Pfam
PF04810 zf-Sec23_Sec24, 1 hit
SUPFAMiSSF82919 SSF82919, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3V3G5_HUMAN
AccessioniPrimary (citable) accession number: G3V3G5
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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