UniProtKB - G3V2N5 (G3V2N5_HUMAN)
Protein
Submitted name:
Alpha-actinin-1
Gene
ACTN1
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- actin binding Source: UniProtKB-KW
Keywordsi
Molecular function | Actin-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Alpha-actinin-1Imported |
Gene namesi | Name:ACTN1Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000072110.13 |
HGNCi | HGNC:163, ACTN1 |
PTM / Processingi
Proteomic databases
PeptideAtlasi | G3V2N5 |
PRIDEi | G3V2N5 |
ProteomicsDBi | 32691 |
PTM databases
SwissPalmi | G3V2N5 |
Expressioni
Gene expression databases
Bgeei | ENSG00000072110, Expressed in blood vessel layer and 247 other tissues |
ExpressionAtlasi | G3V2N5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 10 – 114 | Calponin-homology (CH)InterPro annotationAdd BLAST | 105 | |
Domaini | 123 – 229 | Calponin-homology (CH)InterPro annotationAdd BLAST | 107 |
Keywords - Domaini
RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00940000155548 |
HOGENOMi | CLU_005217_5_0_1 |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf |
Pfami | View protein in Pfam PF00307, CH, 2 hits |
SMARTi | View protein in SMART SM00033, CH, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits |
(1+)i Sequence
Sequence statusi: Fragment.
This entry has 1 described isoform and 10 potential isoforms that are computationally mapped.Show allAlign All
G3V2N5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGLRYVLPLR PPGKTFTAWC NSHLRKAGTQ IENIEEDFRD GLKLMLLLEV
60 70 80 90 100
ISGERLAKPE RGKMRVHKIS NVNKALDFIA SKGVKLVSIG AEEIVDGNVK
110 120 130 140 150
MTLGMIWTII LRFAIQDISV EETSAKEGLL LWCQRKTAPY KNVNIQNFHI
160 170 180 190 200
SWKDGLGFCA LIHRHRPELI DYGKLRKDDP LTNLNTAFDV AEKYLDIPKM
210 220 230 240 250
LDAEDIVGTA RPDEKAIMTY VSSFYHAFSG AQKAETAANR ICKVLAVNQE
260
NEQLMEDYEK
Computationally mapped potential isoform sequencesi
There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketP12814 | ACTN1_HUMAN | Alpha-actinin-1 | ACTN1 | 892 | Annotation score: | ||
H9KV75 | H9KV75_HUMAN | Alpha-actinin cytoskeletal isoform | ACTN1 | 822 | Annotation score: | ||
H7C5W8 | H7C5W8_HUMAN | Alpha-actinin-1 | ACTN1 | 297 | Annotation score: | ||
H0YJ11 | H0YJ11_HUMAN | Alpha-actinin-1 | ACTN1 | 207 | Annotation score: | ||
H0YJW3 | H0YJW3_HUMAN | Alpha-actinin-1 | ACTN1 | 251 | Annotation score: | ||
G3V2W4 | G3V2W4_HUMAN | Alpha-actinin-1 | ACTN1 | 238 | Annotation score: | ||
G3V2X9 | G3V2X9_HUMAN | Alpha-actinin-1 | ACTN1 | 144 | Annotation score: | ||
G3V5M4 | G3V5M4_HUMAN | Alpha-actinin-1 | ACTN1 | 126 | Annotation score: | ||
G3V2E8 | G3V2E8_HUMAN | Alpha-actinin-1 | ACTN1 | 85 | Annotation score: | ||
G3V380 | G3V380_HUMAN | Alpha-actinin-1 | ACTN1 | 72 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 260 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117694 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENST00000556433; ENSP00000450764; ENSG00000072110 |
UCSCi | uc059ctl.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL117694 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
PTM databases
SwissPalmi | G3V2N5 |
Proteomic databases
PeptideAtlasi | G3V2N5 |
PRIDEi | G3V2N5 |
ProteomicsDBi | 32691 |
Protocols and materials databases
Antibodypediai | 51, 462 antibodies |
Genome annotation databases
Ensembli | ENST00000556433; ENSP00000450764; ENSG00000072110 |
UCSCi | uc059ctl.1, human |
Organism-specific databases
EuPathDBi | HostDB:ENSG00000072110.13 |
HGNCi | HGNC:163, ACTN1 |
OpenTargetsi | ENSG00000072110 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155548 |
HOGENOMi | CLU_005217_5_0_1 |
Miscellaneous databases
ChiTaRSi | ACTN1, human |
Gene expression databases
Bgeei | ENSG00000072110, Expressed in blood vessel layer and 247 other tissues |
ExpressionAtlasi | G3V2N5, baseline and differential |
Family and domain databases
CDDi | cd00014, CH, 2 hits |
Gene3Di | 1.10.418.10, 2 hits |
InterProi | View protein in InterPro IPR001589, Actinin_actin-bd_CS IPR001715, CH-domain IPR036872, CH_dom_sf |
Pfami | View protein in Pfam PF00307, CH, 2 hits |
SMARTi | View protein in SMART SM00033, CH, 2 hits |
SUPFAMi | SSF47576, SSF47576, 1 hit |
PROSITEi | View protein in PROSITE PS00020, ACTININ_2, 1 hit PS50021, CH, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V2N5_HUMAN | |
Accessioni | G3V2N5Primary (citable) accession number: G3V2N5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | October 5, 2016 | |
Last modified: | August 12, 2020 | |
This is version 68 of the entry and version 8 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |