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Protein
Submitted name:

Homeobox protein SIX4

Gene

SIX4

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi224 – 274HomeoboxPROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingPROSITE-ProRule annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Homeobox protein SIX4Imported
Gene namesi
Name:SIX4Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000100625.8
HGNCiHGNC:10890 SIX4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusPROSITE-ProRule annotation

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100625

PTM / Processingi

Proteomic databases

EPDiG3V2N2
MaxQBiG3V2N2
PeptideAtlasiG3V2N2
PRIDEiG3V2N2

Expressioni

Gene expression databases

BgeeiENSG00000100625 Expressed in 165 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiG3V2N2 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliG3V2N2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini222 – 273HomeoboxInterPro annotationAdd BLAST52

Keywords - Domaini

HomeoboxPROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0775 Eukaryota
ENOG410XRPB LUCA
GeneTreeiENSGT00540000070251

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR031701 SIX1_SD
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF16878 SIX1_SD, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequence (1+)i

Sequence statusi: Fragment.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3V2N2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIASAADIKQ ENGMESASEG QEAHREVAGG AAVGLSPPAP APFPLEPGDA
60 70 80 90 100
ATAAARVSGE EGAVAAAAAG AAADQVQLHS ELLGRHHHAA AAAAQTPLAF
110 120 130 140 150
SPDHVACVCE ALQQGGNLDR LARFLWSLPQ SDLLRGNESL LKARALVAFH
160 170 180 190 200
QGIYPELYSI LESHSFESAN HPLLQQLWYK ARYTEAERAR GRPLGAVDKY
210 220 230 240 250
RLRRKFPLPR TIWDGEETVY CFKEKSRNAL KELYKQNRYP SPAEKRHLAK
260 270 280 290 300
ITGLSLTQVS NWFKNRRQRD RNPSETQSKS ESDGNPSTED ESSKGHEDLS
310 320 330 340 350
PHPLSSSSDG ITNLSLSSHM EPVYMQQIGN AKISLSSSGV LLNGSLVPAS
360 370 380 390 400
TSPVFLNGNS FIQGPSGVIL NGLNVGNTQA VALNPPKMSS NIVSNGISMT
410 420 430 440 450
DILGSTSQDV KEFKVLQSSA NSATTTSYSP SVPVSFPGLI PSTEVKREGI
460 470 480 490
QTVASQDGGS VVTFTTPVQI NQYGIVQIPN SGANSQFLNG SIGF
Length:494
Mass (Da):52,680
Last modified:November 13, 2013 - v3
Checksum:i22F78BF543B52B8A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9UIU6SIX4_HUMAN
Homeobox protein SIX4
SIX4
781Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei494Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132777 Genomic DNA No translation available.

Genome annotation databases

EnsembliENST00000556952; ENSP00000450761; ENSG00000100625
UCSCiuc059cea.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL132777 Genomic DNA No translation available.

3D structure databases

ProteinModelPortaliG3V2N2
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

EPDiG3V2N2
MaxQBiG3V2N2
PeptideAtlasiG3V2N2
PRIDEiG3V2N2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000556952; ENSP00000450761; ENSG00000100625
UCSCiuc059cea.1 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000100625.8
HGNCiHGNC:10890 SIX4
OpenTargetsiENSG00000100625
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0775 Eukaryota
ENOG410XRPB LUCA
GeneTreeiENSGT00540000070251

Miscellaneous databases

ChiTaRSiSIX4 human

Gene expression databases

BgeeiENSG00000100625 Expressed in 165 organ(s), highest expression level in quadriceps femoris
ExpressionAtlasiG3V2N2 baseline and differential

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR031701 SIX1_SD
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PF16878 SIX1_SD, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3V2N2_HUMAN
AccessioniPrimary (citable) accession number: G3V2N2
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 13, 2013
Last modified: September 12, 2018
This is version 56 of the entry and version 3 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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