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Protein
Submitted name:

Tyrosyl-DNA phosphodiesterase 1

Gene

TDP1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
Tyrosyl-DNA phosphodiesterase 1Imported
Gene namesi
Name:TDP1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000042088.13
HGNCiHGNC:18884 TDP1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000042088

PTM / Processingi

Proteomic databases

MaxQBiG3V2F4
PeptideAtlasiG3V2F4
PRIDEiG3V2F4

Expressioni

Gene expression databases

BgeeiENSG00000042088 Expressed in 170 organ(s), highest expression level in oocyte
ExpressionAtlasiG3V2F4 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliG3V2F4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG2031 Eukaryota
ENOG410XQPZ LUCA
GeneTreeiENSGT00390000002211

Family and domain databases

Gene3Di3.30.870.20, 1 hit
InterProiView protein in InterPro
IPR010347 Tdp1
IPR027415 TDP_C
PANTHERiPTHR12415 PTHR12415, 1 hit
PfamiView protein in Pfam
PF06087 Tyr-DNA_phospho, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 13 potential isoforms that are computationally mapped.iShow all

G3V2F4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQEGDYGRW TISSSDESEE EKPKPDKPST SSLLCARQGA ANEPRYTCSE
60 70 80 90 100
AQKAAHKRKI SPVKFSNTDS VLPPKRQKSG SQEDLGWCLS SSDDELQPEM
110 120 130 140 150
PQKQAEKVVI KKEKDISAPN DGTAQRTENH GAPACHRLKE EEDEYETSGE
160 170 180 190 200
GQDIWDMLDK GNPFQFYLTR VSGVKPKYNS GALHIKDILS PLFGTLVSSA
210 220 230 240 250
QFNYCFDVDW LVKQYPPEFR KKPILLVHGD KREAKAHLHA QAKPYENISL
260 270 280 290 300
CQAKLDIAFG THHTKMMLLL YEEGLRVVIH TSNLIHADWH QKTQGIWLSP
310 320 330 340 350
LYPRIADGTH KSGESPTHFK ADLISYLMAY NAPSLKEWID VIHKHDLSET
360 370 380 390 400
NVYLIGSTPG RFQGSQKDNW GHFRLKKLLK DHASSMPNAE SWPVVGQFSS
410 420 430 440 450
VGSLGADESK WLCSEFKESM LTLGKESKTP GKSSVPLYLI YPSVENVRTS
460 470 480 490 500
LEGYPAGGSL PYSIQTAEKQ NWLHSYFHKW SAETSGRSNA MPHIKTYMRP
510 520 530 540 550
SPDFSKIAWF LVTSANLSKA AWGALEKNGT QLMIRSYELG VLFLPSAFIG
560 570
HGYGTFLMSK HRIRMGTCGC PPENLEAL
Length:578
Mass (Da):64,827
Last modified:November 16, 2011 - v1
Checksum:i0F90149A23B0ECB0
GO

Computationally mapped potential isoform sequencesi

There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q9NUW8TYDP1_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
608Annotation score:
E7EPD8E7EPD8_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
589Annotation score:
G3V2U6G3V2U6_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
279Annotation score:
G3V5B8G3V5B8_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
151Annotation score:
G3V3Q0G3V3Q0_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
146Annotation score:
G3V554G3V554_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
161Annotation score:
G3V5F9G3V5F9_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
147Annotation score:
H0YJ44H0YJ44_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
281Annotation score:
G3V2J6G3V2J6_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
219Annotation score:
G3V5H9G3V5H9_HUMAN
Tyrosyl-DNA phosphodiesterase 1
TDP1
259Annotation score:
There are more potential isoformsShow all

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL137128 Genomic DNA No translation available.
RefSeqiNP_001317134.1, NM_001330205.1
XP_011535246.1, XM_011536944.1
XP_016876929.1, XM_017021440.1
UniGeneiHs.209945

Genome annotation databases

EnsembliENST00000555880; ENSP00000450628; ENSG00000042088
GeneIDi55775
UCSCiuc059eft.1 human

Similar proteinsi

Entry informationi

Entry nameiG3V2F4_HUMAN
AccessioniPrimary (citable) accession number: G3V2F4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 12, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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