UniProtKB - G3V1S1 (G3V1S1_HUMAN)
Protein
DNA excision repair protein ERCC-3
Gene
ERCC3
Organism
Homo sapiens (Human)
Status
Functioni
Catalytic activityi
- EC:3.6.4.12ARBA annotation
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- nucleotide-excision repair Source: InterPro
- transcription initiation from RNA polymerase II promoter Source: InterPro
Keywordsi
Molecular function | DNA-bindingARBA annotation, HydrolaseARBA annotation |
Ligand | ATP-bindingARBA annotation, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: DNA excision repair protein ERCC-3ARBA annotation (EC:3.6.4.12ARBA annotation)Alternative name(s): General transcription and DNA repair factor IIH helicase subunit XPBARBA annotation |
Gene namesi | Name:ERCC3Imported ORF Names:hCG_42607Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
PTM / Processingi
Proteomic databases
MaxQBi | G3V1S1 |
PeptideAtlasi | G3V1S1 |
PRIDEi | G3V1S1 |
ProteomicsDBi | 32422 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 263 – 424 | Helicase ATP-bindingInterPro annotationAdd BLAST | 162 | |
Domaini | 478 – 638 | Helicase C-terminalInterPro annotationAdd BLAST | 161 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 154 – 177 | DisorderedSequence analysisAdd BLAST | 24 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 154 – 175 | PolarSequence analysisAdd BLAST | 22 |
Sequence similaritiesi
Phylogenomic databases
OrthoDBi | 100698at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR032438, ERCC3_RAD25_C IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR001161, XPB/Ssl2 IPR032830, XPB/Ssl2_N |
Pfami | View protein in Pfam PF16203, ERCC3_RAD25_C, 1 hit PF13625, Helicase_C_3, 1 hit PF04851, ResIII, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00603, rad25, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
i Sequence
Sequence statusi: Complete.
G3V1S1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPLKDDHTSR PLWVAPDGHI FLEAFSPVYK YAQDFLVAIA EPVCRPTHVH
60 70 80 90 100
EYKLTAYSLY AAVSVGLQTS DITEYLRKLS KTGVPDGIMQ FIKLCTVSYG
110 120 130 140 150
KVKLVLKHNR YFVESCHPDV IQHLLQDPVI RECRLRNSEG EATELITETF
160 170 180 190 200
TSKSAISKTA ESSGGPSTSR VTDPQGKSDI PMDLFDFYEQ MDKDEEEEEE
210 220 230 240 250
TQTVSFEVKQ EMIEELQKRC IHLEYPLLAE YDFRNDSVNP DINIDLKPTA
260 270 280 290 300
VLRPYQEKSL RKMFGNGRAR SGVIVLPCGA GKSLVGVTAA CTVRKRCLVL
310 320 330 340 350
GNSAVSVEQW KAQFKMWSTI DDSQICRFTS DAKDKPIGCS VAISTYSMLG
360 370 380 390 400
HTTKRSWEAE RVMEWLKTQE WGLMILDEVH TIPAKMFRRV LTIVQAHCKL
410 420 430 440 450
GLTATLVRED DKIVDLNFLI GPKLYEANWM ELQNNGYIAK VQCAEVWCPM
460 470 480 490 500
SPEFYREYVA IKTKKRILLY TMNPNKFRAC QFLIKFHERR NDKIIVFADN
510 520 530 540 550
VFALKEYAIR LNKPYIYGPT SQGERMQILQ NFKHNPKINT IFISKVGDTS
560 570 580 590 600
FDLPEANVLI QISSHGGSRR QEAQRLGRVL RAKKGMVAEE YNAFFYSLVS
610 620 630 640 650
QDTQEMAYST KRQRFLVDQG YSFKVITKLA GMEEEDLAFS TKEEQQQLLQ
660 670 680 690 700
KVLAATDLDA EEEVVAGEFG SRSSQASRRF GTMSSMSGAD DTVYMEYHSS
710
RSKAPSKHVH PLFKRFRK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471103 Genomic DNA Translation: EAW95312.1 CH471103 Genomic DNA Translation: EAW95314.1 |
RefSeqi | NP_001290345.1, NM_001303416.1 NP_001290347.1, NM_001303418.1 |
Genome annotation databases
GeneIDi | 2071 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CH471103 Genomic DNA Translation: EAW95312.1 CH471103 Genomic DNA Translation: EAW95314.1 |
RefSeqi | NP_001290345.1, NM_001303416.1 NP_001290347.1, NM_001303418.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
MaxQBi | G3V1S1 |
PeptideAtlasi | G3V1S1 |
PRIDEi | G3V1S1 |
ProteomicsDBi | 32422 |
Genome annotation databases
GeneIDi | 2071 |
Organism-specific databases
CTDi | 2071 |
Phylogenomic databases
OrthoDBi | 100698at2759 |
Miscellaneous databases
BioGRID-ORCSi | 2071, 628 hits in 883 CRISPR screens |
ChiTaRSi | ERCC3, human |
GenomeRNAii | 2071 |
Family and domain databases
InterProi | View protein in InterPro IPR032438, ERCC3_RAD25_C IPR006935, Helicase/UvrB_N IPR014001, Helicase_ATP-bd IPR001650, Helicase_C IPR027417, P-loop_NTPase IPR001161, XPB/Ssl2 IPR032830, XPB/Ssl2_N |
Pfami | View protein in Pfam PF16203, ERCC3_RAD25_C, 1 hit PF13625, Helicase_C_3, 1 hit PF04851, ResIII, 1 hit |
SMARTi | View protein in SMART SM00487, DEXDc, 1 hit SM00490, HELICc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 2 hits |
TIGRFAMsi | TIGR00603, rad25, 1 hit |
PROSITEi | View protein in PROSITE PS51192, HELICASE_ATP_BIND_1, 1 hit PS51194, HELICASE_CTER, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V1S1_HUMAN | |
Accessioni | G3V1S1Primary (citable) accession number: G3V1S1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 71 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |