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UniProtKB - G3V1R5 (G3V1R5_HUMAN)

Entry version 89 (10 Feb 2021)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Nardilysin

Gene

NRDC

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, MetalloproteaseARBA annotation, Protease
LigandZincARBA annotation

Protein family/group databases

MEROPS protease database

More...MEROPSi		M16.987

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
NardilysinImported
Submitted name:
Nardilysin (N-arginine dibasic convertase), isoform CRA_eImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRDCImported
Synonyms:NRD1Imported
ORF Names:hCG_40292Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:7995, NRDC

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000078618.19

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...OpenTargetsi		ENSG00000078618

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		G3V1R5

PRoteomics IDEntifications database

More...PRIDEi		G3V1R5

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		32416

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000078618, Expressed in quadriceps femoris and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		G3V1R5, baseline and differential

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini144 – 272Peptidase_M16InterPro annotationAdd BLAST129
Domaini299 – 483Peptidase_M16_CInterPro annotationAdd BLAST185
Domaini489 – 770Peptidase_M16_MInterPro annotationAdd BLAST282
Domaini775 – 956Peptidase_M16_CInterPro annotationAdd BLAST182

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 73DisorderedSequence analysisAdd BLAST73

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili928 – 948Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi7 – 64AcidicSequence analysisAdd BLAST58

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peptidase M16 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...GeneTreei		ENSGT00940000155026

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_004639_1_0_1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011249, Metalloenz_LuxS/M16
IPR011765, Pept_M16_N
IPR001431, Pept_M16_Zn_BS
IPR007863, Peptidase_M16_C
IPR032632, Peptidase_M16_M

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00675, Peptidase_M16, 1 hit
PF05193, Peptidase_M16_C, 2 hits
PF16187, Peptidase_M16_M, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF63411, SSF63411, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00143, INSULINASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3V1R5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGKTGNTTD DEEEEEVEEE EEDDDEDSGA EIEDDDEEGF DDEDEFDDEH 
        60         70         80         90        100
DDDLDTEDNE LEELEERAEA RKKTTEKQQL QSLFLLWSKL TDRLWFKSTY 
       110        120        130        140        150
SKMSSTLLVE TRNLYGVVGA ESRSAPVQHL AGWQAEEQQG ETDTVLSAAA 
       160        170        180        190        200
LCVGVGSFAD PDDLPGLAHF LEHMVFMGSL KYPDENGFDA FLKKHGGSDN 
       210        220        230        240        250
ASTDCERTVF QFDVQRKYFK EALDRWAQFF IHPLMIRDAI DREVEAVDSE 
       260        270        280        290        300
YQLARPSDAN RKEMLFGSLA RPGHPMGKFF WGNAETLKHE PRKNNIDTHA 
       310        320        330        340        350
RLREFWMRYY SSHYMTLVVQ SKETLDTLEK WVTEIFSQIP NNGLPRPNFG 
       360        370        380        390        400
HLTDPFDTPA FNKLYRVVPI RKIHALTITW ALPPQQQHYR VKPLHYISWL 
       410        420        430        440        450
VGHEGKGSIL SFLRKKCWAL ALFGGNGETG FEQNSTYSVF SISITLTDEG 
       460        470        480        490        500
YEHFYEVAYT VFQYLKMLQK LGPEKRIFEE IRKIEDNEFH YQEQTDPVEY 
       510        520        530        540        550
VENMCENMQL YPLQDILTGD QLLFEYKPEV IGEALNQLVP QKANLVLLSG 
       560        570        580        590        600
ANEGKCDLKE KWFGTQYSIE DIENSWAELW NSNFELNPDL HLPAENKYIA 
       610        620        630        640        650
TDFTLKAFDC PETEYPVKIV NTPQGCLWYK KDNKFKIPKA YIRFHLISPL 
       660        670        680        690        700
IQKSAANVVL FDIFVNILTH NLAEPAYEAD VAQLEYKLVA GEHGLIIRVK 
       710        720        730        740        750
GFNHKLPLLF QLIIDYLAEF NSTPAVFTMI TEQLKKTYFN ILIKPETLAK 
       760        770        780        790        800
DVRLLILEYA RWSMIDKYQA LMDGLSLESL LSFVKEFKSQ LFVEGLVQGN 
       810        820        830        840        850
VTSTESMDFL KYVVDKLNFK PLEQEMPVQF QVVELPSGHH LCKVKALNKG 
       860        870        880        890        900
DANSEVTVYY QSGTRSLREY TLMELLVMHM EEPCFDFLRT KQTLGYHVYP 
       910        920        930        940        950
TCRNTSGILG FSVTVGTQAT KYNSEVVDKK IEEFLSSFEE KIENLTEEAF 
       960        970        980        990       1000
NTQVTALIKL KECEDTHLGE EVDRNWNEVV TQQYLFDRLA HEIEALKSFS 
      1010       1020       1030       1040       1050
KSDLVNWFKA HRGPGSKMLS VHVVGYGKYE LEEDGTPSSE DSNSSCEVMQ 
      1060       1070       1080 
LTYLPTSPLL ADCIIPITDI RAFTTTLNLL PYHKIVK
Length:1,087
Mass (Da):125,119
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E675CC85574DC2F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O43847NRDC_HUMAN
Nardilysin
NRDC NRD1
1,151Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F5H7V1F5H7V1_HUMAN
Nardilysin
NRDC
949Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0Y5G9H0Y5G9_HUMAN
Nardilysin
NRDC
538Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AL050343 Genomic DNA No translation available.
AL589663 Genomic DNA No translation available.
KF495940 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06808.1

NCBI Reference Sequences

More...RefSeqi		NP_001229290.1, NM_001242361.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000539524; ENSP00000444416; ENSG00000078618

Database of genes from NCBI RefSeq genomes

More...GeneIDi		4898

UCSC genome browser

More...UCSCi		uc001cte.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL050343 Genomic DNA No translation available.
AL589663 Genomic DNA No translation available.
KF495940 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX06808.1
RefSeqiNP_001229290.1, NM_001242361.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein family/group databases

MEROPSiM16.987

Proteomic databases

MaxQBiG3V1R5
PRIDEiG3V1R5
ProteomicsDBi32416

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		19043, 140 antibodies

Genome annotation databases

EnsembliENST00000539524; ENSP00000444416; ENSG00000078618
GeneIDi4898
UCSCiuc001cte.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		4898
HGNCiHGNC:7995, NRDC
OpenTargetsiENSG00000078618
VEuPathDBiHostDB:ENSG00000078618.19

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

GeneTreeiENSGT00940000155026
HOGENOMiCLU_004639_1_0_1

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		4898, 98 hits in 876 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		NRDC, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		4898

Gene expression databases

BgeeiENSG00000078618, Expressed in quadriceps femoris and 244 other tissues
ExpressionAtlasiG3V1R5, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR011249, Metalloenz_LuxS/M16
IPR011765, Pept_M16_N
IPR001431, Pept_M16_Zn_BS
IPR007863, Peptidase_M16_C
IPR032632, Peptidase_M16_M
PfamiView protein in Pfam
PF00675, Peptidase_M16, 1 hit
PF05193, Peptidase_M16_C, 2 hits
PF16187, Peptidase_M16_M, 1 hit
SUPFAMiSSF63411, SSF63411, 4 hits
PROSITEiView protein in PROSITE
PS00143, INSULINASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V1R5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V1R5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: February 10, 2021
This is version 89 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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