UniProtKB - G3V1R5 (G3V1R5_HUMAN)
Protein
Submitted name:
Nardilysin
Gene
NRDC
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- metal ion binding Source: InterPro
- metallopeptidase activity Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, MetalloproteaseARBA annotation, Protease |
Ligand | ZincARBA annotation |
Protein family/group databases
MEROPSi | M16.987 |
Names & Taxonomyi
Protein namesi | Submitted name: NardilysinImportedSubmitted name: Nardilysin (N-arginine dibasic convertase), isoform CRA_eImported |
Gene namesi | ORF Names:hCG_40292Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:7995, NRDC |
VEuPathDBi | HostDB:ENSG00000078618.19 |
Expressioni
Gene expression databases
Bgeei | ENSG00000078618, Expressed in quadriceps femoris and 244 other tissues |
ExpressionAtlasi | G3V1R5, baseline and differential |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 144 – 272 | Peptidase_M16InterPro annotationAdd BLAST | 129 | |
Domaini | 299 – 483 | Peptidase_M16_CInterPro annotationAdd BLAST | 185 | |
Domaini | 489 – 770 | Peptidase_M16_MInterPro annotationAdd BLAST | 282 | |
Domaini | 775 – 956 | Peptidase_M16_CInterPro annotationAdd BLAST | 182 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 73 | DisorderedSequence analysisAdd BLAST | 73 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 928 – 948 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 7 – 64 | AcidicSequence analysisAdd BLAST | 58 |
Sequence similaritiesi
Belongs to the peptidase M16 family.UniRule annotation
Keywords - Domaini
Coiled coilSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000155026 |
HOGENOMi | CLU_004639_1_0_1 |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 2 hits PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 4 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
G3V1R5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEGKTGNTTD DEEEEEVEEE EEDDDEDSGA EIEDDDEEGF DDEDEFDDEH
60 70 80 90 100
DDDLDTEDNE LEELEERAEA RKKTTEKQQL QSLFLLWSKL TDRLWFKSTY
110 120 130 140 150
SKMSSTLLVE TRNLYGVVGA ESRSAPVQHL AGWQAEEQQG ETDTVLSAAA
160 170 180 190 200
LCVGVGSFAD PDDLPGLAHF LEHMVFMGSL KYPDENGFDA FLKKHGGSDN
210 220 230 240 250
ASTDCERTVF QFDVQRKYFK EALDRWAQFF IHPLMIRDAI DREVEAVDSE
260 270 280 290 300
YQLARPSDAN RKEMLFGSLA RPGHPMGKFF WGNAETLKHE PRKNNIDTHA
310 320 330 340 350
RLREFWMRYY SSHYMTLVVQ SKETLDTLEK WVTEIFSQIP NNGLPRPNFG
360 370 380 390 400
HLTDPFDTPA FNKLYRVVPI RKIHALTITW ALPPQQQHYR VKPLHYISWL
410 420 430 440 450
VGHEGKGSIL SFLRKKCWAL ALFGGNGETG FEQNSTYSVF SISITLTDEG
460 470 480 490 500
YEHFYEVAYT VFQYLKMLQK LGPEKRIFEE IRKIEDNEFH YQEQTDPVEY
510 520 530 540 550
VENMCENMQL YPLQDILTGD QLLFEYKPEV IGEALNQLVP QKANLVLLSG
560 570 580 590 600
ANEGKCDLKE KWFGTQYSIE DIENSWAELW NSNFELNPDL HLPAENKYIA
610 620 630 640 650
TDFTLKAFDC PETEYPVKIV NTPQGCLWYK KDNKFKIPKA YIRFHLISPL
660 670 680 690 700
IQKSAANVVL FDIFVNILTH NLAEPAYEAD VAQLEYKLVA GEHGLIIRVK
710 720 730 740 750
GFNHKLPLLF QLIIDYLAEF NSTPAVFTMI TEQLKKTYFN ILIKPETLAK
760 770 780 790 800
DVRLLILEYA RWSMIDKYQA LMDGLSLESL LSFVKEFKSQ LFVEGLVQGN
810 820 830 840 850
VTSTESMDFL KYVVDKLNFK PLEQEMPVQF QVVELPSGHH LCKVKALNKG
860 870 880 890 900
DANSEVTVYY QSGTRSLREY TLMELLVMHM EEPCFDFLRT KQTLGYHVYP
910 920 930 940 950
TCRNTSGILG FSVTVGTQAT KYNSEVVDKK IEEFLSSFEE KIENLTEEAF
960 970 980 990 1000
NTQVTALIKL KECEDTHLGE EVDRNWNEVV TQQYLFDRLA HEIEALKSFS
1010 1020 1030 1040 1050
KSDLVNWFKA HRGPGSKMLS VHVVGYGKYE LEEDGTPSSE DSNSSCEVMQ
1060 1070 1080
LTYLPTSPLL ADCIIPITDI RAFTTTLNLL PYHKIVK
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketO43847 | NRDC_HUMAN | Nardilysin | NRDC NRD1 | 1,151 | Annotation score: | ||
F5H7V1 | F5H7V1_HUMAN | Nardilysin | NRDC | 949 | Annotation score: | ||
H0Y5G9 | H0Y5G9_HUMAN | Nardilysin | NRDC | 538 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050343 Genomic DNA No translation available. AL589663 Genomic DNA No translation available. KF495940 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06808.1 |
RefSeqi | NP_001229290.1, NM_001242361.1 |
Genome annotation databases
Ensembli | ENST00000539524; ENSP00000444416; ENSG00000078618 |
GeneIDi | 4898 |
UCSCi | uc001cte.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL050343 Genomic DNA No translation available. AL589663 Genomic DNA No translation available. KF495940 Genomic DNA No translation available. CH471059 Genomic DNA Translation: EAX06808.1 |
RefSeqi | NP_001229290.1, NM_001242361.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein family/group databases
MEROPSi | M16.987 |
Proteomic databases
MaxQBi | G3V1R5 |
PRIDEi | G3V1R5 |
ProteomicsDBi | 32416 |
Protocols and materials databases
Antibodypediai | 19043, 140 antibodies |
Genome annotation databases
Ensembli | ENST00000539524; ENSP00000444416; ENSG00000078618 |
GeneIDi | 4898 |
UCSCi | uc001cte.4, human |
Organism-specific databases
CTDi | 4898 |
HGNCi | HGNC:7995, NRDC |
OpenTargetsi | ENSG00000078618 |
VEuPathDBi | HostDB:ENSG00000078618.19 |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00940000155026 |
HOGENOMi | CLU_004639_1_0_1 |
Miscellaneous databases
BioGRID-ORCSi | 4898, 98 hits in 876 CRISPR screens |
ChiTaRSi | NRDC, human |
GenomeRNAii | 4898 |
Gene expression databases
Bgeei | ENSG00000078618, Expressed in quadriceps femoris and 244 other tissues |
ExpressionAtlasi | G3V1R5, baseline and differential |
Family and domain databases
InterProi | View protein in InterPro IPR011249, Metalloenz_LuxS/M16 IPR011765, Pept_M16_N IPR001431, Pept_M16_Zn_BS IPR007863, Peptidase_M16_C IPR032632, Peptidase_M16_M |
Pfami | View protein in Pfam PF00675, Peptidase_M16, 1 hit PF05193, Peptidase_M16_C, 2 hits PF16187, Peptidase_M16_M, 1 hit |
SUPFAMi | SSF63411, SSF63411, 4 hits |
PROSITEi | View protein in PROSITE PS00143, INSULINASE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V1R5_HUMAN | |
Accessioni | G3V1R5Primary (citable) accession number: G3V1R5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | February 10, 2021 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |