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Entry version 88 (07 Apr 2021)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Probable E3 ubiquitin-protein ligase MARCHF10

Gene

MARCHF10

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Probable E3 ubiquitin-protein ligase MARCHF10Imported
Submitted name:
Ring finger protein 190, isoform CRA_cImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MARCHF10Imported
Synonyms:RNF190Imported
ORF Names:hCG_2039713Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:26655, MARCHF10

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000173838.11

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000173838

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
G3V1Q5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
32406

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173838, Expressed in right testis and 110 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
G3V1Q5, baseline and differential

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
G3V1Q5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini650 – 720RING-CH-typeInterPro annotationAdd BLAST71

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni33 – 81DisorderedSequence analysisAdd BLAST49
Regioni101 – 231DisorderedSequence analysisAdd BLAST131
Regioni243 – 266DisorderedSequence analysisAdd BLAST24
Regioni304 – 413DisorderedSequence analysisAdd BLAST110

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi33 – 54PolyampholyteSequence analysisAdd BLAST22
Compositional biasi55 – 74PolarSequence analysisAdd BLAST20
Compositional biasi146 – 164PolarSequence analysisAdd BLAST19
Compositional biasi315 – 331PolarSequence analysisAdd BLAST17
Compositional biasi332 – 348PolyampholyteSequence analysisAdd BLAST17
Compositional biasi380 – 404PolyampholyteSequence analysisAdd BLAST25

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063836

Identification of Orthologs from Complete Genome Data

More...
OMAi
HDYERDW

Database of Orthologous Groups

More...
OrthoDBi
517602at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd16813, RING_CH-C4HC3_MARCH10, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.30.40.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR042583, MARCH10_RING_CH-C4HC3
IPR011016, Znf_RING-CH
IPR013083, Znf_RING/FYVE/PHD

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12906, RINGv, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00744, RINGv, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51292, ZF_RING_CH, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All

G3V1Q5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHDARDRQK FFSDVQYLRD MQHKVDSEYQ ACLRRQEYRR DPNEKKRDQF
60 70 80 90 100
WGQETSFERS RFSSRSSSKQ SSSEEDALTE PRSSIKISAF KCDSKLPAID
110 120 130 140 150
QTSVKQKHKS TMTVRKAEKV DPSEPSPDQA PMVLLRKRKP NLRRFTVSPE
160 170 180 190 200
SHSPRASGDR SRQKQQWPAK VPVPRGADQV VQQEGLMCNT KLKRPNQERR
210 220 230 240 250
NLVPSSQPMT ENAPDRAKKG DPSAPSQSEL HPALSQAFQG KNSPQVLSEF
260 270 280 290 300
SGPPLTPTTV GGPRKASFRF RDEDFYSILS LNSRRESDDT EEETQSEECL
310 320 330 340 350
WVGVRSPCSP SHHKRSRFGG TSTPQAKNKN FEENAENCRG HSSRRSEPSH
360 370 380 390 400
GSLRISNAME PATERPSAGQ RLSQDPGLPD RESATEKDRG GSENAKKSPL
410 420 430 440 450
SWDTKSEPRQ EVGVNAENVW SDCISVEHRP GTHDSEGYWK DYLNSSQNSL
460 470 480 490 500
DYFISGRPIS PRSSVNSSYN PPASFMHSAL RDDIPVDLSM SSTSVHSSDS
510 520 530 540 550
EGNSGFHVCQ PLSPIRNRTP FASAENHNYF PVNSAHEFAV REAEDTTLTS
560 570 580 590 600
QPQGAPLYTD LLLNPQGNLS LVDSSSSSPS RMNSEGHLHV SGSLQENTPF
610 620 630 640 650
TFFAVSHFPN QNDNGSRMAA SGFTDEKETS KIKADPEKLK KLQESLLEED
660 670 680 690 700
SEEEGDLCRI CQIAGGSPSN PLLEPCGCVG SLQFVHQECL KKWLKVKITS
710 720 730 740 750
GADLGAVKTC EMCKQGLLVD LGDFNMIEFY QKHQQSQAQN ELMNSGLYLV
760 770 780 790
LLLHLYEQRF AELMRLNHNQ VERERLSRNY PQPRTEENES RFWGPVLPF
Length:799
Mass (Da):89,825
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i122DF2BDD6ED5597
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8NA82MARHA_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10 MARCH10, RNF190
808Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTN9J3KTN9_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10 RNF190, hCG_2039713
846Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QRH7J3QRH7_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10
693Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3KTK3J3KTK3_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10
61Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
J3QLJ2J3QLJ2_HUMAN
Probable E3 ubiquitin-protein ligas...
MARCHF10
164Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC005821 Genomic DNA No translation available.
AC068512 Genomic DNA No translation available.
AC080038 Genomic DNA No translation available.
KF456303 Genomic DNA No translation available.
KF459572 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94340.1

NCBI Reference Sequences

More...
RefSeqi
NP_001275709.1, NM_001288780.1
XP_005257160.1, XM_005257103.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000544856; ENSP00000443746; ENSG00000173838

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
162333

UCSC genome browser

More...
UCSCi
uc002jah.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC005821 Genomic DNA No translation available.
AC068512 Genomic DNA No translation available.
AC080038 Genomic DNA No translation available.
KF456303 Genomic DNA No translation available.
KF459572 Genomic DNA No translation available.
CH471109 Genomic DNA Translation: EAW94340.1
RefSeqiNP_001275709.1, NM_001288780.1
XP_005257160.1, XM_005257103.1

3D structure databases

SMRiG3V1Q5
ModBaseiSearch...

Proteomic databases

PRIDEiG3V1Q5
ProteomicsDBi32406

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
18645, 197 antibodies

The DNASU plasmid repository

More...
DNASUi
162333

Genome annotation databases

EnsembliENST00000544856; ENSP00000443746; ENSG00000173838
GeneIDi162333
UCSCiuc002jah.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
162333
HGNCiHGNC:26655, MARCHF10
OpenTargetsiENSG00000173838
VEuPathDBiHostDB:ENSG00000173838.11

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

GeneTreeiENSGT00530000063836
OMAiHDYERDW
OrthoDBi517602at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
162333, 8 hits in 961 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
MARCH10, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
162333

Gene expression databases

BgeeiENSG00000173838, Expressed in right testis and 110 other tissues
ExpressionAtlasiG3V1Q5, baseline and differential

Family and domain databases

CDDicd16813, RING_CH-C4HC3_MARCH10, 1 hit
Gene3Di3.30.40.10, 1 hit
InterProiView protein in InterPro
IPR042583, MARCH10_RING_CH-C4HC3
IPR011016, Znf_RING-CH
IPR013083, Znf_RING/FYVE/PHD
PfamiView protein in Pfam
PF12906, RINGv, 1 hit
SMARTiView protein in SMART
SM00744, RINGv, 1 hit
PROSITEiView protein in PROSITE
PS51292, ZF_RING_CH, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3V1Q5_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3V1Q5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: April 7, 2021
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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