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UniProtKB - G3V1J5 (G3V1J5_HUMAN)
Protein
Submitted name:
Exosome complex exonuclease RRP44
Gene
DIS3
Organism
Homo sapiens (Human)
Status
Functioni
GO - Molecular functioni
- ribonuclease activity Source: InterPro
- RNA binding Source: UniProtKB-KW
Keywordsi
Molecular function | HydrolaseARBA annotation, RNA-bindingARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Exosome complex exonuclease RRP44ImportedSubmitted name: KIAA1008, isoform CRA_cImported |
Gene namesi | ORF Names:hCG_32200Imported |
Organismi | Homo sapiens (Human)Imported |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:20604, DIS3 |
VEuPathDBi | HostDB:ENSG00000083520 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
Other locations
- exosome (RNase complex) Source: UniProtKB-KW
Keywords - Cellular componenti
ExosomeARBA annotationExpressioni
Gene expression databases
Bgeei | ENSG00000083520, Expressed in calcaneal tendon and 224 other tissues |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 305 – 635 | RNBInterPro annotationAdd BLAST | 331 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 776 – 796 | DisorderedSequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the RNR ribonuclease family.ARBA annotation
Phylogenomic databases
GeneTreei | ENSGT00530000063106 |
HOGENOMi | CLU_002333_5_0_1 |
OMAi | VQYKPFP |
Family and domain databases
InterProi | View protein in InterPro IPR041505, Dis3_CSD2 IPR012340, NA-bd_OB-fold IPR001900, RNase_II/R IPR022966, RNase_II/R_CS IPR033771, Rrp44_CSD1 IPR033770, RRP44_S1 |
Pfami | View protein in Pfam PF17849, OB_Dis3, 1 hit PF00773, RNB, 1 hit PF17216, Rrp44_CSD1, 1 hit PF17215, Rrp44_S1, 1 hit |
SMARTi | View protein in SMART SM00955, RNB, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits |
PROSITEi | View protein in PROSITE PS01175, RIBONUCLEASE_II, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G3V1J5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSADNQLQVI FITNDRRNKE KAIEEGIPAF TCEEYVKSLT ANPELIDRLA
60 70 80 90 100
CLSEEGNEIE SGKIIFSEHL PLSKLQQGIK SGTYLQGTFR ASRENYLEAT
110 120 130 140 150
VWIHGDNEEN KEIILQGLKH LNRAVHEDIV AVELLPKSQW VAPSSVVLHD
160 170 180 190 200
EGQNEEDVEK EEETERMLKT AVSEKMLKPT GRVVGIIKRN WRPYCGMLSK
210 220 230 240 250
SDIKESRRHL FTPADKRIPR IRIETRQAST LEGRRIIVAI DGWPRNSRYP
260 270 280 290 300
NGHFVRNLGD VGEKETETEV LLLEHDVPHQ PFSQAVLSFL PKMPWSITEK
310 320 330 340 350
DMKNREDLRH LCICSVDPPG CTDIDDALHC RELENGNLEV GVHIADVSHF
360 370 380 390 400
IRPGNALDQE SARRGTTVYL CEKRIDMVPE LLSSNLCSLK CDVDRLAFSC
410 420 430 440 450
IWEMNHNAEI LKTKFTKSVI NSKASLTYAE AQLRIDSANM NDDITTSLRG
460 470 480 490 500
LNKLAKILKK RRIEKGALTL SSPEVRFHMD SETHDPIDLQ TKELRETNSM
510 520 530 540 550
VEEFMLLANI SVAKKIHEEF SEHALLRKHP APPPSNYEIL VKAARSRNLE
560 570 580 590 600
IKTDTAKSLA ESLDQAESPT FPYLNTLLRI LATRCMMQAV YFCSGMDNDF
610 620 630 640 650
HHYGLASPIY THFTSPIRRY ADVIVHRLLA VAIGADCTYP ELTDKHKLAD
660 670 680 690 700
ICKNLNFRHK MAQYAQRASV AFHTQLFFKS KGIVSEEAYI LFVRKNAIVV
710 720 730 740 750
LIPKYGLEGT VFFEEKDKPN PQLIYDDEIP SLKIEDTVFH VFDKVKVKIM
760 770 780 790
LDSSNLQHQK IRMSLVEPQI PGISIPTDTS NMDLNGPKKK KMKLGK
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ9Y2L1 | RRP44_HUMAN | Exosome complex exonuclease RRP44 | DIS3 KIAA1008, RRP44 | 958 | Annotation score: | ||
F2Z2C0 | F2Z2C0_HUMAN | Exosome complex exonuclease RRP44 | DIS3 | 559 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138695 Genomic DNA No translation available. AL391384 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80519.1 |
RefSeqi | NP_001309278.1, NM_001322349.1 |
Genome annotation databases
Ensembli | ENST00000545453; ENSP00000440058; ENSG00000083520 |
GeneIDi | 22894 |
UCSCi | uc058xku.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL138695 Genomic DNA No translation available. AL391384 Genomic DNA No translation available. CH471093 Genomic DNA Translation: EAW80519.1 |
RefSeqi | NP_001309278.1, NM_001322349.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
ProteomicsDBi | 32352 |
Protocols and materials databases
Antibodypediai | 24401, 219 antibodies from 30 providers |
DNASUi | 22894 |
Genome annotation databases
Ensembli | ENST00000545453; ENSP00000440058; ENSG00000083520 |
GeneIDi | 22894 |
UCSCi | uc058xku.1, human |
Organism-specific databases
CTDi | 22894 |
HGNCi | HGNC:20604, DIS3 |
OpenTargetsi | ENSG00000083520 |
VEuPathDBi | HostDB:ENSG00000083520 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
GeneTreei | ENSGT00530000063106 |
HOGENOMi | CLU_002333_5_0_1 |
OMAi | VQYKPFP |
Miscellaneous databases
BioGRID-ORCSi | 22894, 562 hits in 1057 CRISPR screens |
ChiTaRSi | DIS3, human |
GenomeRNAii | 22894 |
Gene expression databases
Bgeei | ENSG00000083520, Expressed in calcaneal tendon and 224 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR041505, Dis3_CSD2 IPR012340, NA-bd_OB-fold IPR001900, RNase_II/R IPR022966, RNase_II/R_CS IPR033771, Rrp44_CSD1 IPR033770, RRP44_S1 |
Pfami | View protein in Pfam PF17849, OB_Dis3, 1 hit PF00773, RNB, 1 hit PF17216, Rrp44_CSD1, 1 hit PF17215, Rrp44_S1, 1 hit |
SMARTi | View protein in SMART SM00955, RNB, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits |
PROSITEi | View protein in PROSITE PS01175, RIBONUCLEASE_II, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3V1J5_HUMAN | |
Accessioni | G3V1J5Primary (citable) accession number: G3V1J5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | January 19, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |