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Protein
Submitted name:

Gasdermin domain containing 1, isoform CRA_d

Gene

GSDMD

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Submitted name:
Gasdermin domain containing 1, isoform CRA_dImported
Submitted name:
Gasdermin-DImported
Gene namesi
Name:GSDMDImported
Synonyms:GSDMDC1Imported
ORF Names:hCG_32063Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000104518.10
HGNCiHGNC:25697 GSDMD

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000104518

PTM / Processingi

Proteomic databases

PRIDEiG3V1A6

Expressioni

Gene expression databases

BgeeiENSG00000104518 Expressed in 171 organ(s), highest expression level in spleen

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili335 – 355Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

eggNOGiENOG410IKA4 Eukaryota
ENOG4111D9N LUCA
GeneTreeiENSGT00530000063218
OMAiQGPTCAL
OrthoDBiEOG091G09ST

Family and domain databases

InterProiView protein in InterPro
IPR007677 Gasdermin
PANTHERiPTHR16399 PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598 Gasdermin, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All

G3V1A6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISAHCNLHL PGSSDSLASA SQLLLAGRLP GRADAPDAPP SGRRRSRSMG
60 70 80 90 100
SAFERVVRRV VQELDHGGEF IPVTSLQSST GFQPYCLVVR KPSSSWFWKP
110 120 130 140 150
RYKCVNLSIK DILEPDAAEP DVQRGRSFHF YDAMDGQIQG SVELAAPGQA
160 170 180 190 200
KIAGGAAVSD SSSTSMNVYS LSVDPNTWQT LLHERHLRQP EHKVLQQLRS
210 220 230 240 250
RGDNVYVVTE VLQTQKEVEV TRTHKREGSG RFSLPGATCL QGEGQGHLSQ
260 270 280 290 300
KKTVTIPSGS TLAFRVAQLV IDSDLDVLLF PDKKQRTFQP PATGHKRSTS
310 320 330 340 350
EGAWPQLPSG LSMMRCLHNF LTDGVPAEGA FTEDFQGLRA EVETISKELE
360 370 380 390 400
LLDRELCQLL LEGLEGVLRD QLALRALEEA LEQGQSLGPV EPLDGPAGAV
410 420 430 440 450
LECLVLSSGM LVPELAIPVV YLLGALTMLS ETQHKLLAEA LESQTLLGPL
460 470 480 490 500
ELVGSLLEQS APWQERSTMS LPPGLLGNSW GEGAPAWVLL DECGLELGED
510 520 530
TPHVCWEPQA QGRMCALYAS LALLSGLSQE PH
Length:532
Mass (Da):57,735
Last modified:November 16, 2011 - v1
Checksum:i00CF9D6D647A42B0
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P57764GSDMD_HUMAN
Gasdermin-D
GSDMD DFNA5L, GSDMDC1, FKSG10
484Annotation score:
E9PIB2E9PIB2_HUMAN
Gasdermin-D
GSDMD
277Annotation score:
E9PQ48E9PQ48_HUMAN
Gasdermin-D
GSDMD
114Annotation score:
E9PQR9E9PQR9_HUMAN
Gasdermin-D
GSDMD
164Annotation score:
E9PRF1E9PRF1_HUMAN
Gasdermin-D
GSDMD
48Annotation score:
E9PNZ0E9PNZ0_HUMAN
Gasdermin-D
GSDMD
153Annotation score:
H0YDB0H0YDB0_HUMAN
Gasdermin-D
GSDMD
231Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82246.1
UniGeneiHs.118983

Genome annotation databases

EnsembliENST00000533063; ENSP00000433958; ENSG00000104518
ENST00000628703; ENSP00000486410; ENSG00000278718
UCSCiuc003yyf.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC067930 Genomic DNA No translation available.
CH471162 Genomic DNA Translation: EAW82246.1
UniGeneiHs.118983

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiG3V1A6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000533063; ENSP00000433958; ENSG00000104518
ENST00000628703; ENSP00000486410; ENSG00000278718
UCSCiuc003yyf.4 human

Organism-specific databases

EuPathDBiHostDB:ENSG00000104518.10
HGNCiHGNC:25697 GSDMD
OpenTargetsiENSG00000104518
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IKA4 Eukaryota
ENOG4111D9N LUCA
GeneTreeiENSGT00530000063218
OMAiQGPTCAL
OrthoDBiEOG091G09ST

Miscellaneous databases

ChiTaRSiGSDMD human

Gene expression databases

BgeeiENSG00000104518 Expressed in 171 organ(s), highest expression level in spleen

Family and domain databases

InterProiView protein in InterPro
IPR007677 Gasdermin
PANTHERiPTHR16399 PTHR16399, 1 hit
PfamiView protein in Pfam
PF04598 Gasdermin, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3V1A6_HUMAN
AccessioniPrimary (citable) accession number: G3V1A6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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