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UniProtKB - G3UXB3 (NKX11_MOUSE)
Protein
NK1 transcription factor-related protein 1
Gene
Nkx1-1
Organism
Mus musculus (Mouse)
Status
Functioni
May be required for the coordinated crosstalk of factors involved in the maintenance of energy homeostasis, possibly by regulating the transcription of specific factors involved in energy balance.
2 PublicationsRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 288 – 347 | HomeoboxPROSITE-ProRule annotationAdd BLAST | 60 |
GO - Molecular functioni
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- cell differentiation Source: GO_Central
- lipid metabolic process Source: MGI
- nervous system process Source: MGI
- regulation of generation of precursor metabolites and energy Source: MGI
- regulation of glucose metabolic process Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: NK1 transcription factor-related protein 1CuratedAlternative name(s): Homeobox protein SAX-2 NKX-1.1 |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:109346, Nkx1-1 |
VEuPathDBi | HostDB:ENSMUSG00000029112 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Homozygous knockout mice for Sax2 exhibit growth retardation starting immediately after birth and leading to premature death within the first 3 weeks postnatal. Mice do not exhibit any obvious abnormal behavior or motor skills. All mice show normal suckling behavior, but at 2 or 3 days prior to their death, they become lethargic and show signs of wasting. The few homozygous animals surviving to adulthood are fertile, but all the offspring from homozygous intermatings die within 4 days postnatally (PubMed:14645517, PubMed:17879320). At 2 weeks postnatal days, mice lack subcutaneous fat and intra-abdominal epididymal and mesenteric white adipose tissue (WAT) (PubMed:17879320).2 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000452744 | 1 – 440 | NK1 transcription factor-related protein 1Add BLAST | 440 |
Proteomic databases
PaxDbi | G3UXB3 |
PTM databases
iPTMneti | G3UXB3 |
PhosphoSitePlusi | G3UXB3 |
Expressioni
Developmental stagei
Detected as early as embryonic stage 10.5 dpc in the ventral mesencephalon, metencephalon, and ventral neural tube and continues to be expressed from this embryonic stage onward, predominantly in the ventral neural tube and the mid/hindbrain boundary region. In the later stages, 12.5 to 16.5 dpc, expression in the brain is detected more specifically in the pons and medulla oblongata.1 Publication
Inductioni
Autoregulated by a negative-feedback mechanism in the ventral midbrain and a positive-feedback mechanism in the midbrain-hindbrain boundary region and the eyes.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000029112, Expressed in hindbrain and 15 other tissues |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000133620 |
Miscellaneous databases
RNActi | G3UXB3, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 43 | DisorderedSequence analysisAdd BLAST | 43 | |
Regioni | 107 – 253 | DisorderedSequence analysisAdd BLAST | 147 | |
Regioni | 304 – 349 | DisorderedSequence analysisAdd BLAST | 46 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 146 – 163 | Acidic residuesSequence analysisAdd BLAST | 18 | |
Compositional biasi | 237 – 253 | Basic and acidic residuesSequence analysisAdd BLAST | 17 |
Sequence similaritiesi
Belongs to the NK-1 homeobox family.Curated
Keywords - Domaini
HomeoboxPhylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000162861 |
HOGENOMi | CLU_063378_1_0_1 |
InParanoidi | G3UXB3 |
OMAi | NDTNGYS |
PhylomeDBi | G3UXB3 |
TreeFami | TF316128 |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
i Sequence
Sequence statusi: Complete.
G3UXB3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSTSGPAAPG DVPALPPPPP GPGSGPAPPA PAATARDTMD GRAELPIFPR
60 70 80 90 100
AGVPPLAASD TVPAVPEGAG AARPAAPPRP TSFSVLDILD PNKFNSRRRR
110 120 130 140 150
CVLLGPVVPA TCAPCAPAAC VAVPAASGRS PRAELERRAL SAATGVAAAA
160 170 180 190 200
GAEPTSAGDS YRADEAEANG YSSGSGRSPT ADSEDEAPED EDEEEAPEVQ
210 220 230 240 250
DAQGTEEPRG GSGGLGARGS GCPGAAEVEA SPVDDTAAPG PRGNSPGAPG
260 270 280 290 300
PPATATGAGS AGSTPQGAAV TTKPKRKRTG SDSKSGKPRR ARTAFTYEQL
310 320 330 340 350
VALENKFKAT RYLSVCERLN LALSLSLTET QVKIWFQNRR TKWKKQNPGA
360 370 380 390 400
DTSAPTGGGG GPGPGAGPGA GLPGGLSPLS PSPPMGAPLA LHGPAGYPAH
410 420 430 440
SPGGLVCAAQ LPFLSSPAVL SPFVLGSQTY GAPAFYAPHL
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC145072 Genomic DNA No translation available. |
Genome annotation databases
UCSCi | uc056zzg.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC145072 Genomic DNA No translation available. |
3D structure databases
AlphaFoldDBi | G3UXB3 |
SMRi | G3UXB3 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000133620 |
PTM databases
iPTMneti | G3UXB3 |
PhosphoSitePlusi | G3UXB3 |
Proteomic databases
PaxDbi | G3UXB3 |
Protocols and materials databases
Antibodypediai | 22251, 85 antibodies from 12 providers |
Genome annotation databases
UCSCi | uc056zzg.1, mouse |
Organism-specific databases
MGIi | MGI:109346, Nkx1-1 |
VEuPathDBi | HostDB:ENSMUSG00000029112 |
Phylogenomic databases
eggNOGi | KOG0488, Eukaryota |
GeneTreei | ENSGT00940000162861 |
HOGENOMi | CLU_063378_1_0_1 |
InParanoidi | G3UXB3 |
OMAi | NDTNGYS |
PhylomeDBi | G3UXB3 |
TreeFami | TF316128 |
Miscellaneous databases
RNActi | G3UXB3, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029112, Expressed in hindbrain and 15 other tissues |
Family and domain databases
CDDi | cd00086, homeodomain, 1 hit |
InterProi | View protein in InterPro IPR009057, Homeobox-like_sf IPR017970, Homeobox_CS IPR001356, Homeobox_dom IPR020479, Homeobox_metazoa |
Pfami | View protein in Pfam PF00046, Homeodomain, 1 hit |
PRINTSi | PR00024, HOMEOBOX |
SMARTi | View protein in SMART SM00389, HOX, 1 hit |
SUPFAMi | SSF46689, SSF46689, 1 hit |
PROSITEi | View protein in PROSITE PS00027, HOMEOBOX_1, 1 hit PS50071, HOMEOBOX_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NKX11_MOUSE | |
Accessioni | G3UXB3Primary (citable) accession number: G3UXB3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 2, 2021 |
Last sequence update: | February 23, 2022 | |
Last modified: | May 25, 2022 | |
This is version 76 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families