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Protein

Replication factor C subunit 1

Gene

Rfc1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processDNA replicationUniRule annotation
LigandATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-110312 Translesion synthesis by REV1
R-MMU-110314 Recognition of DNA damage by PCNA-containing replication complex
R-MMU-110320 Translesion Synthesis by POLH
R-MMU-174411 Polymerase switching on the C-strand of the telomere
R-MMU-5651801 PCNA-Dependent Long Patch Base Excision Repair
R-MMU-5655862 Translesion synthesis by POLK
R-MMU-5656121 Translesion synthesis by POLI
R-MMU-5656169 Termination of translesion DNA synthesis
R-MMU-5685942 HDR through Homologous Recombination (HRR)
R-MMU-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER
R-MMU-5696400 Dual Incision in GG-NER
R-MMU-6782135 Dual incision in TC-NER
R-MMU-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER
R-MMU-69091 Polymerase switching

Names & Taxonomyi

Protein namesi
Recommended name:
Replication factor C subunit 1UniRule annotation
Gene namesi
Name:Rfc1Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:97891 Rfc1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotation

PTM / Processingi

Proteomic databases

PeptideAtlasiG3UWX1
PRIDEiG3UWX1

Expressioni

Gene expression databases

BgeeiENSMUSG00000029191 Expressed in 301 organ(s), highest expression level in saccule of membranous labyrinth
ExpressionAtlasiG3UWX1 baseline and differential

Structurei

3D structure databases

ProteinModelPortaliG3UWX1
SMRiG3UWX1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini413 – 491BRCTInterPro annotationAdd BLAST79

Sequence similaritiesi

Belongs to the activator 1 large subunit family.UniRule annotation

Phylogenomic databases

GeneTreeiENSGT00730000111066
OMAiPKMKPFD

Family and domain databases

CDDicd00027 BRCT, 1 hit
Gene3Di3.40.50.10190, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
IPR008921 DNA_pol3_clamp-load_cplx_C
IPR013725 DNA_replication_fac_RFC1_C
IPR027417 P-loop_NTPase
IPR012178 RFC1
PfamiView protein in Pfam
PF00004 AAA, 1 hit
PF00533 BRCT, 1 hit
PF08519 RFC1, 1 hit
PIRSFiPIRSF036578 RFC1, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00292 BRCT, 1 hit
SUPFAMiSSF48019 SSF48019, 1 hit
SSF52113 SSF52113, 1 hit
SSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50172 BRCT, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

G3UWX1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDIRKFFGVI SSGKKPVNET VKNEKTKASE GTVKGKKGVK EAKVNNSGKE
60 70 80 90 100
DASKPKQHSK KKRIINDSDS ESEETVQVKN AKKKSEKLSL SYKPGKVSQK
110 120 130 140 150
DPVTYVSETD EDDDFVCKKA ASKSKENGVS TNSYLGTSNV KKNEENVKTK
160 170 180 190 200
NKPLSPIKLT PTSVLDYFGT ESVQRSGKKM VTSKRKEPDF CLSCLIFFGI
210 220 230 240 250
QSSQNTEDSR LNDEAIAKQL QLDEDAELER QLHEDEEFAR TLALLDEEPK
260 270 280 290 300
IKKARKDSEE GEESFSSVQD DLSKAEKQKS PNKAELFSTA RKTYSPAKHG
310 320 330 340 350
KGRASEDAKQ PCKSAHRKEA CSSPKASAKL ALMKAKEESS YNETELLAAR
360 370 380 390 400
RKESATEPKG EKTTPKKTKV SPTKRESVSP EDSEKKRTNY QAYRSYLNRE
410 420 430 440 450
GPKALGSKEI PKGAENCLEG LTFVITGVLE SIERDEAKSL IERYGGKVTG
460 470 480 490 500
NVSKKTNYLV MGRDSGQSKS DKAAALGTKI LDEDGLLDLI RTMPGKRSKY
510 520 530 540 550
EMAAEAEMKK EKSKLERTPQ KNDQGKRKIS PAKKESESKK CKLTLLKNSP
560 570 580 590 600
MKAVKKEAST CPRGLDVKET HGNRSSNKEE CLLWVDKYKP ASLKNIIGQQ
610 620 630 640 650
GDQSCANKLL RWLRNWHKSS PEEKKHAKFG KLASKDDGSS FKAALLSGPP
660 670 680 690 700
GVGKTTTASL VCQELGYSYV ELNASDTRSK NSLKAVVAES LNNTSIKGFY
710 720 730 740 750
TSGAAPSVSA RHALIMDEVD GMAGNEDRGG IQELIGLIKH TKIPIICMCN
760 770 780 790 800
DRNHPKIRSL VHYCFDLRFQ RPRVEQIKSA MLSIAFKEGL KIPPPAMNEI
810 820 830 840 850
ILGANQDVRQ VLHNLSMWCA QSKALTYDQA KADSQRAKKD IRLGPFDVTR
860 870 880 890 900
KVFAAGEETA HMSLMDKSDL FFHDYSIAPL FVQENYLHVK PVAAGGDMKK
910 920 930 940 950
HLMLLSRAAD SICDGDLVDN QIRSKQNWSL LPTQAIYASV LPGELMRGYM
960 970 980 990 1000
TQFPSFPSWL GKHSSTGKHD RIVQDLSLHM SLRTYSSKRT VNMDYLSHIR
1010 1020 1030 1040 1050
DALVRPLTSQ GVEGAQHVIK LMDTYYLMKE DFENIMEVSS WGGKPSAFSK
1060 1070 1080 1090 1100
LDPKVKAAFT RAYNKEAHLT PYSLQVVKTS RLSTGPALDS EYSEEFQEDD
1110 1120 1130 1140
TQSEKEQDAV ETDAMIKQKK TRSSKPSKSE REKESKKGKG KNWKK
Length:1,145
Mass (Da):127,578
Last modified:July 22, 2015 - v2
Checksum:iF7680E6492A0D1DD
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P35601RFC1_MOUSE
Replication factor C subunit 1
Rfc1 Ibf-1, Recc1
1,131Annotation score:
Q5U4B1Q5U4B1_MOUSE
Replication factor C subunit 1
Rfc1
1,132Annotation score:
G3X8Z6G3X8Z6_MOUSE
Replication factor C subunit 1
Rfc1 Recc1, mCG_10254
1,131Annotation score:
A0A0N5E9G7A0A0N5E9G7_MOUSE
Replication factor C subunit 1
Rfc1
1,130Annotation score:
A0A0N4SVN6A0A0N4SVN6_MOUSE
Replication factor C subunit 1
Rfc1
212Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC138654 Genomic DNA No translation available.

Genome annotation databases

EnsembliENSMUST00000203581; ENSMUSP00000145385; ENSMUSG00000029191
UCSCiuc008xnj.2 mouse

Similar proteinsi

Entry informationi

Entry nameiG3UWX1_MOUSE
AccessioniPrimary (citable) accession number: G3UWX1
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: July 22, 2015
Last modified: September 12, 2018
This is version 57 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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