Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Melanocortin 5 receptor

Gene

Mc5r

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Names & Taxonomyi

Protein namesi
Submitted name:
Melanocortin 5 receptorImported
Submitted name:
Melanocortin receptor 5Imported
Gene namesi
Name:Mc5rImported
ORF Names:mCG_6054Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:99420 Mc5r

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei85 – 109HelicalSequence analysisAdd BLAST25
Transmembranei164 – 185HelicalSequence analysisAdd BLAST22
Transmembranei206 – 226HelicalSequence analysisAdd BLAST21
Transmembranei232 – 259HelicalSequence analysisAdd BLAST28
Transmembranei280 – 303HelicalSequence analysisAdd BLAST24
Transmembranei323 – 344HelicalSequence analysisAdd BLAST22

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000007480 Expressed in 46 organ(s), highest expression level in lumbar subsegment of spinal cord

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 342G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST243

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
KOiK04203
OMAiVSLYIHM
OrthoDBiEOG091G0BVW
TreeFamiTF332646

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001908 Melancort_rcpt
IPR000621 Melancort_rcpt_5
IPR001671 Melcrt_ACTH_rcpt
PANTHERiPTHR22750:SF5 PTHR22750:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00535 MELNOCORTINR
PR01063 MELNOCORTN5R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3UWB6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQDQSPVNRR FNSQKPPGTR EESCLPLRGA EQNGKSDAKK WGHSLPAMNS
60 70 80 90 100
SSTLTVLNLT LNASEDGILG SNVKNKSLAC EEMGIAVEVF LTLGLVSLLE
110 120 130 140 150
NILVIGAIVK NKNLHSPMYF FVGSLAVADM LVSMSNAWET VTIYLLNNKH
160 170 180 190 200
LVIADTFVRH IDNVFDSMIC ISVVASMCSL LAIAVDRYIT IFYALRYHHI
210 220 230 240 250
MTARRSGVII ACIWTFCISC GIVFIIYYES KYVIICLISM FFTMLFFMVS
260 270 280 290 300
LYIHMFLLAR NHVKRIAASP RYNSVRQRTS MKGAITLTML LGIFIVCWSP
310 320 330 340 350
FFLHLILMIS CPQNVYCSCF MSYFNMYLIL IMCNSVIDPL IYALRSQEMR
360 370
RTFKEIVCCH GFRRPCRLLG GY
Length:372
Mass (Da):42,170
Last modified:November 16, 2011 - v1
Checksum:i995B5214BFBD3E1F
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P41149MC5R_MOUSE
Melanocortin receptor 5
Mc5r
325Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111069 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL09610.1
RefSeqiNP_038624.2, NM_013596.2
UniGeneiMm.8003

Genome annotation databases

EnsembliENSMUST00000172148; ENSMUSP00000130497; ENSMUSG00000007480
GeneIDi17203
KEGGimmu:17203
UCSCiuc008fnl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC111069 Genomic DNA No translation available.
CH466528 Genomic DNA Translation: EDL09610.1
RefSeqiNP_038624.2, NM_013596.2
UniGeneiMm.8003

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000172148; ENSMUSP00000130497; ENSMUSG00000007480
GeneIDi17203
KEGGimmu:17203
UCSCiuc008fnl.2 mouse

Organism-specific databases

CTDi4161
MGIiMGI:99420 Mc5r

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00770000120529
KOiK04203
OMAiVSLYIHM
OrthoDBiEOG091G0BVW
TreeFamiTF332646

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-418555 G alpha (s) signalling events

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000007480 Expressed in 46 organ(s), highest expression level in lumbar subsegment of spinal cord

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR001908 Melancort_rcpt
IPR000621 Melancort_rcpt_5
IPR001671 Melcrt_ACTH_rcpt
PANTHERiPTHR22750:SF5 PTHR22750:SF5, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00534 MCRFAMILY
PR00535 MELNOCORTINR
PR01063 MELNOCORTN5R
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3UWB6_MOUSE
AccessioniPrimary (citable) accession number: G3UWB6
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: November 7, 2018
This is version 55 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again