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Entry version 70 (31 Jul 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Zinc finger protein 423

Gene

Zfp423

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Zinc finger protein 423Imported
Submitted name:
Zinc finger protein 423, isoform CRA_bImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zfp423Imported
ORF Names:mCG_14464Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 8

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1891217 Zfp423

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045333 Expressed in 248 organ(s), highest expression level in brain

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini21 – 48C2H2-typeInterPro annotationAdd BLAST28
Domaini49 – 76C2H2-typeInterPro annotationAdd BLAST28
Domaini77 – 104C2H2-typeInterPro annotationAdd BLAST28
Domaini105 – 132C2H2-typeInterPro annotationAdd BLAST28
Domaini146 – 174C2H2-typeInterPro annotationAdd BLAST29
Domaini178 – 206C2H2-typeInterPro annotationAdd BLAST29
Domaini363 – 391C2H2-typeInterPro annotationAdd BLAST29
Domaini400 – 423C2H2-typeInterPro annotationAdd BLAST24
Domaini515 – 537C2H2-typeInterPro annotationAdd BLAST23
Domaini545 – 567C2H2-typeInterPro annotationAdd BLAST23
Domaini575 – 599C2H2-typeInterPro annotationAdd BLAST25
Domaini603 – 631C2H2-typeInterPro annotationAdd BLAST29
Domaini633 – 661C2H2-typeInterPro annotationAdd BLAST29
Domaini664 – 691C2H2-typeInterPro annotationAdd BLAST28
Domaini690 – 713C2H2-typeInterPro annotationAdd BLAST24
Domaini769 – 796C2H2-typeInterPro annotationAdd BLAST28
Domaini813 – 840C2H2-typeInterPro annotationAdd BLAST28
Domaini842 – 869C2H2-typeInterPro annotationAdd BLAST28
Domaini1003 – 1031C2H2-typeInterPro annotationAdd BLAST29
Domaini1051 – 1078C2H2-typeInterPro annotationAdd BLAST28
Domaini1081 – 1108C2H2-typeInterPro annotationAdd BLAST28
Domaini1112 – 1140C2H2-typeInterPro annotationAdd BLAST29
Domaini1142 – 1167C2H2-typeInterPro annotationAdd BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni229 – 282DisorderedSequence analysisAdd BLAST54
Regioni473 – 510DisorderedSequence analysisAdd BLAST38
Regioni1019 – 1046DisorderedSequence analysisAdd BLAST28

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi232 – 272PolarSequence analysisAdd BLAST41
Compositional biasi483 – 510PolarSequence analysisAdd BLAST28
Compositional biasi1019 – 1033PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Zinc-fingerPROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158492

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096 zf-C2H2, 6 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355 ZnF_C2H2, 29 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 10 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 24 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3UW89-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MIGDGCDLGL GEEEGGTGLP YPCQFCDKSF IRLSYLKRHE QIHSDKLPFK
60 70 80 90 100
CTFCSRLFKH KRSRDRHIKL HTGDKKYHCH ECEAAFSRSD HLKIHLKTHS
110 120 130 140 150
SSKPFKCSVC KRGFSSTSSL QSHMQAHKKN KEHLAKSEKE AKKDDFMCDY
160 170 180 190 200
CEDTFSQTEE LEKHVLTLHP QLSEKADLQC IHCPEVFVDE STLLAHIHQA
210 220 230 240 250
HANQKHKCPM CPEQFSSVEG VYCHLDSHRQ PDSSNHSVSP DPVLGSVASM
260 270 280 290 300
SSATPDSSAS VERGSTPDST LKPLRGQKKM RDDGQSWPKV VYSCPYCSKR
310 320 330 340 350
DFTSLAVLEI HLKTIHADKP QQSHTCQICL DSMPTLYNLN EHVRKLHKSH
360 370 380 390 400
AYPVMQFGNI SAFHCNYCPE MFADINSLQE HIRVSHCGPN ANPPDGNNAF
410 420 430 440 450
FCNQCSMGFL TESSLTEHIQ QAHCSVGSTK LESPVVQPTQ SFMEVYSCPY
460 470 480 490 500
CTNSPIFGSI LKLTKHIKEN HKNIPLAHSK KSKAEQSPVS SDVEVSSPKR
510 520 530 540 550
QRLSGSANSI SNGEYPCNQC DLKFSNFESF QTHLKLHLEL LLRKQACPQC
560 570 580 590 600
KEDFDSQESL LQHLTVHYMT TSTHYVCESC DKQFSSVDDL QKHLLDMHTF
610 620 630 640 650
VLYHCTLCQE VFDSKVSIQV HLAVKHSNEK KMYRCTACNW DFRKEADLQV
660 670 680 690 700
HVKHSHLGNP AKAHKCIFCG ETFSTEVELQ CHITTHSKKY NCRFCSKAFH
710 720 730 740 750
AVILLEKHLR EKHCVFDAAA ENGTANGVPP TSTKKAEPAD LQGMLLKNPE
760 770 780 790 800
APNSHEASED DVDASEPMYG CDICGAAYTM EVLLQNHRLR DHNIRPGEDD
810 820 830 840 850
GSRKKAEFIK GSHKCNVCSR TFFSENGLRE HLQTHRGPAK HYMCPICGER
860 870 880 890 900
FPSLLTLTEH KVTHSKSLDT GTCRICKMPL QSEEEFIEHC QMHPDLRNSL
910 920 930 940 950
TGFRCVVCMQ TVTSTLELKI HGTFHMQKLA GSSAASSPNG QGLQKLYKCA
960 970 980 990 1000
LCLKEFRSKQ DLVRLDVNGL PYGLCAGCMA RSANGQVGGL APPEPADRPC
1010 1020 1030 1040 1050
AGLRCPECNV KFESAEDLES HMQVDHRDLT PETSGPRKGA QTSPVPRKKT
1060 1070 1080 1090 1100
YQCIKCQMTF ENEREIQIHV ANHMIEEGIN HECKLCNQMF DSPAKLLCHL
1110 1120 1130 1140 1150
IEHSFEGMGG TFKCPVCFTV FVQANKLQQH IFAVHGQEDK IYDCSQCPQK
1160
FFFQTELQNH TMSQHAQ
Length:1,167
Mass (Da):131,579
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCDA7ECD71E0E811E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q80TS5ZN423_MOUSE
Zinc finger protein 423
Znf423 Ebfaz, Kiaa0760, Nur12, Oaz, Zfp423
1,292Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UZP1G3UZP1_MOUSE
Zinc finger protein 423
Zfp423
244Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3UYI9G3UYI9_MOUSE
Zinc finger protein 423
Zfp423
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC121809 Genomic DNA No translation available.
AC127285 Genomic DNA No translation available.
AC171684 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11044.1

NCBI Reference Sequences

More...
RefSeqi
NP_001297449.1, NM_001310520.1
XP_006531602.1, XM_006531539.3
XP_011246863.1, XM_011248561.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000165770; ENSMUSP00000129724; ENSMUSG00000045333

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
94187

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC121809 Genomic DNA No translation available.
AC127285 Genomic DNA No translation available.
AC171684 Genomic DNA No translation available.
CH466525 Genomic DNA Translation: EDL11044.1
RefSeqiNP_001297449.1, NM_001310520.1
XP_006531602.1, XM_006531539.3
XP_011246863.1, XM_011248561.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSMUST00000165770; ENSMUSP00000129724; ENSMUSG00000045333
GeneIDi94187

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
94187
MGIiMGI:1891217 Zfp423

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000158492
OrthoDBi1318335at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Zfp423 mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045333 Expressed in 248 organ(s), highest expression level in brain

Family and domain databases

InterProiView protein in InterPro
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00096 zf-C2H2, 6 hits
SMARTiView protein in SMART
SM00355 ZnF_C2H2, 29 hits
SUPFAMiSSF57667 SSF57667, 10 hits
PROSITEiView protein in PROSITE
PS00028 ZINC_FINGER_C2H2_1, 24 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3UW89_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3UW89
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: July 31, 2019
This is version 70 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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