Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 56 (29 Sep 2021)
Sequence version 1 (16 Nov 2011)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Mannose receptor C-type 1

Gene

MRC1

Organism
Loxodonta africana (African elephant)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionReceptorARBA annotation
Biological processEndocytosisARBA annotation
LigandLectinARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Mannose receptor C-type 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MRC1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLoxodonta africana (African elephant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9785 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1387 – 1410HelicalSequence analysisAdd BLAST24

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 20Sequence analysisAdd BLAST20
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500345644721 – 1455Sequence analysisAdd BLAST1435

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi166 ↔ 192PROSITE-ProRule annotation
Disulfide bondi180 ↔ 207PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9785.ENSLAFP00000029146

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini20 – 140Ricin B-type lectinInterPro annotationAdd BLAST121
Domaini161 – 209Fibronectin type-IIInterPro annotationAdd BLAST49
Domaini228 – 339C-type lectinInterPro annotationAdd BLAST112
Domaini367 – 485C-type lectinInterPro annotationAdd BLAST119
Domaini509 – 624C-type lectinInterPro annotationAdd BLAST116
Domaini653 – 776C-type lectinInterPro annotationAdd BLAST124
Domaini805 – 921C-type lectinInterPro annotationAdd BLAST117
Domaini949 – 1077C-type lectinInterPro annotationAdd BLAST129
Domaini1099 – 1210C-type lectinInterPro annotationAdd BLAST112
Domaini1238 – 1353C-type lectinInterPro annotationAdd BLAST116

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4297, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01040000240474

Identification of Orthologs from Complete Genome Data

More...
OMAi
PYAGNCY

TreeFam database of animal gene trees

More...
TreeFami
TF316663

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00062, FN2, 1 hit
cd00161, RICIN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 1 hit
3.10.100.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits
PF00652, Ricin_B_lectin, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits
SSF57440, SSF57440, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 6 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3UMT7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LFLKVAFVFL FPVFYYETDT RQFLIYNEDH KRCVEALSPS AVQTAACNPD
60 70 80 90 100
NESQKFRWVS DSQVMSVAFK LCLGVPSKTD WVAITLYACD SKNEFQKWEC
110 120 130 140 150
KNDTLFGIKG EDLFFNYGNR QEKNIMLYKG SGLWSRWKIY GTTDDLCSRS
160 170 180 190 200
YEAMFTLLGN ANGATCAFPF KFENKWYADC TSVGRSDGWL WCGTTTDYDT
210 220 230 240 250
DKLFGFCPLK FEGSESLWNK DPLTSIYYQI NSKSALTWHQ ARKSCQQQSA
260 270 280 290 300
ELLSITEIHE QTYLTGLTSS LTSGLWIGLN SLSFNSGWQW SEGSPFRYLN
310 320 330 340 350
WLPGSPSTEP GKSCVSLNPG KNAKWENLEC VQKLGYICKK GNTTLNPFVI
360 370 380 390 400
PSERDVPTSC PSQWWPYAGH CYKIYRGEKK IQRNALTACR KEGGDLASIH
410 420 430 440 450
SIEEFDFIFS QLGYESNDEL WIGLNDIKIQ MYFEWSDGTP VTFTKWLHGE
460 470 480 490 500
PSHENNRQED CVVMKGKDGH WADRACEQPL DYICKMKAQT QVPAIVEVET
510 520 530 540 550
GCRKGWKRHG FFCYLIGHTL STFTEANQTC GNEKAYLTTV EDRYEQAFLT
560 570 580 590 600
SFVGLRPERY FWTGLSDIQS KGTFQWTIEE GVQFTHWNAD MPGRKAGCVA
610 620 630 640 650
MRTGIAGGLW DVLKCDEKAK FVCKHWAEGA TRPPEPTTTP EPKCPEDWGT
660 670 680 690 700
TSKSSLCFKL FTKGKHDKKT WFESRDFCRA LGGDLASINN KEEQQAIWRL
710 720 730 740 750
ITSSSSYHEL FWLGLTYGSP SEGFTWSDGS PVSYEHWAYG EPNNYQNVEF
760 770 780 790 800
CGELKGDPGM FWNDINCEHL NNWICQIKKG QTPKPEPTPA PQDNPPVTED
810 820 830 840 850
GWVIYKEYQY YFSKEKETMD NAREFCKRNF GDLVSIQSES EKKFLWKYVN
860 870 880 890 900
RNDAQSAYFI GLLISLDKKF IWVDGSKVDY VAWATGEPNF ANDDENCVAM
910 920 930 940 950
YSNSGFWNDI NCGYPHAFIC QRHNSSINAT VLPTTPPVKG GCEQGWKSYN
960 970 980 990 1000
NKCFKIFGFV EEERKNWQEA RKACIGFGGN LVSIRNEKEQ AFLTYQMTGS
1010 1020 1030 1040 1050
SFNAWIGLND VNSEHTFLWT DQRGVYYTNW GKGYPGGRRS SLSYEDADCV
1060 1070 1080 1090 1100
VIIGGKSQDA GKWMDDTCDS KRGYICHTLP NPSLPVSPTT VPSDGFINFG
1110 1120 1130 1140 1150
ESSYSLIDLK LSWYEAEKYC TLHNSHIGSI LDPYSNAFVW IQMEKLNSPV
1160 1170 1180 1190 1200
WIALNSNLTN NEYVWTDKWR VRYTNWAADE PKLKSACVYL DTDGYWKTAY
1210 1220 1230 1240 1250
CNESFYSLCK RSNDTPATEP PQLPGRCPES DHTAWIPFHG HCYYIESSYT
1260 1270 1280 1290 1300
KNWGHASLEC LRMGSSLVSI ESAAESSFLS YRVEPLKSKT NFWIGLFRNV
1310 1320 1330 1340 1350
EGMWLWINKN PVSFVNWNAG DPSGERNDCV TLLASSGFWN NVHCSSYKGY
1360 1370 1380 1390 1400
ICKRPKKTVV DAEPTRTLMT TKADSRKMDP SKPSSSVAGI VVIVILLILT
1410 1420 1430 1440 1450
GTGLAAYFFY KKRRVQLPQE STFENTLYFN SRSSPGTNDT KDLMDNIEQN

ERAAI
Length:1,455
Mass (Da):165,941
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i796FFF19D2F50C1A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3TNX9G3TNX9_LOXAF
Mannose receptor C-type 1
MRC1
1,455Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3TGQ1G3TGQ1_LOXAF
Mannose receptor C-type 1
MRC1
1,429Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLAFT00000035654; ENSLAFP00000029146; ENSLAFG00000022148

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9785.ENSLAFP00000029146

Genome annotation databases

EnsembliENSLAFT00000035654; ENSLAFP00000029146; ENSLAFG00000022148

Phylogenomic databases

eggNOGiKOG4297, Eukaryota
GeneTreeiENSGT01040000240474
OMAiPYAGNCY
TreeFamiTF316663

Family and domain databases

CDDicd00062, FN2, 1 hit
cd00161, RICIN, 1 hit
Gene3Di2.10.10.10, 1 hit
3.10.100.10, 8 hits
InterProiView protein in InterPro
IPR001304, C-type_lectin-like
IPR016186, C-type_lectin-like/link_sf
IPR018378, C-type_lectin_CS
IPR016187, CTDL_fold
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013806, Kringle-like
IPR035992, Ricin_B-like_lectins
IPR000772, Ricin_B_lectin
PfamiView protein in Pfam
PF00040, fn2, 1 hit
PF00059, Lectin_C, 8 hits
PF00652, Ricin_B_lectin, 1 hit
SMARTiView protein in SMART
SM00034, CLECT, 8 hits
SM00059, FN2, 1 hit
SM00458, RICIN, 1 hit
SUPFAMiSSF50370, SSF50370, 1 hit
SSF56436, SSF56436, 8 hits
SSF57440, SSF57440, 1 hit
PROSITEiView protein in PROSITE
PS00615, C_TYPE_LECTIN_1, 6 hits
PS50041, C_TYPE_LECTIN_2, 8 hits
PS00023, FN2_1, 1 hit
PS51092, FN2_2, 1 hit
PS50231, RICIN_B_LECTIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3UMT7_LOXAF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3UMT7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: September 29, 2021
This is version 56 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again