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Entry version 32 (05 Jun 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Rho GTPase activating protein 39

Gene

ARHGAP39

Organism
Loxodonta africana (African elephant)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Rho GTPase activating protein 39Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ARHGAP39Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLoxodonta africana (African elephant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9785 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9785.ENSLAFP00000025027

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini63 – 97WWInterPro annotationAdd BLAST35
Domaini728 – 880MyTH4InterPro annotationAdd BLAST153
Domaini927 – 1115Rho-GAPInterPro annotationAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 21DisorderedSequence analysisAdd BLAST21
Regioni112 – 180DisorderedSequence analysisAdd BLAST69
Regioni222 – 264DisorderedSequence analysisAdd BLAST43
Regioni284 – 312DisorderedSequence analysisAdd BLAST29
Regioni331 – 369DisorderedSequence analysisAdd BLAST39
Regioni407 – 433DisorderedSequence analysisAdd BLAST27
Regioni446 – 540DisorderedSequence analysisAdd BLAST95
Regioni571 – 597DisorderedSequence analysisAdd BLAST27

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi112 – 144PolarSequence analysisAdd BLAST33
Compositional biasi224 – 263PolarSequence analysisAdd BLAST40
Compositional biasi285 – 305PolarSequence analysisAdd BLAST21
Compositional biasi469 – 491PolarSequence analysisAdd BLAST23
Compositional biasi503 – 517PolarSequence analysisAdd BLAST15

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IG4K Eukaryota
ENOG410XQ23 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003161

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3UB19

Identification of Orthologs from Complete Genome Data

More...
OMAi
DEVNCMK

TreeFam database of animal gene trees

More...
TreeFami
TF323577

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.555.10, 1 hit
1.25.40.530, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00784 MyTH4, 1 hit
PF00620 RhoGAP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00139 MyTH4, 1 hit
SM00324 RhoGAP, 1 hit
SM00456 WW, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48350 SSF48350, 1 hit
SSF51045 SSF51045, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51016 MYTH4, 1 hit
PS50238 RHOGAP, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3UB19-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSQTQDYDCR SHNADAHESR VSGSSTRLEW VEIIEPRTRE RMYANLVTGE
60 70 80 90 100
CVWDPPTGVR IKRTSDNQWW ELFDPNTSRF YYYNATTQRT VWHRPQNCDI
110 120 130 140 150
IPLAKLQTLK QNTESPRVSA ESSPGRGSAI SREGSPSTSL EPEPDTSEKA
160 170 180 190 200
QELPGQTGRP VPFGATKEEH GGSSPPGVFL EKDYETYRDY GMDGPLLHYR
210 220 230 240 250
ASSLQWTTGT KERMLIKVTD REPSFFTPQG NGFPTDGQPG ARTQRPSSGQ
260 270 280 290 300
HSPGLQTFTP DTDSAIFFPE RRLSPFLKRT ELTGSCSPLP AQPRKPSSDS
310 320 330 340 350
QPSSPRYAYE PPLYEEPPVE YQAPIYDEPP VDMQYEVSGG YKAGSPQKSP
360 370 380 390 400
VRKPRPFLQS PKHASPSPYQ QLVLTKQRGP ERFLSLDYSP AGKEYVRQLV
410 420 430 440 450
YVEQAGSSPK LRAGPRHKYA PNPGGGSYSL QPSPCLVRDQ RLEARSGDYS
460 470 480 490 500
SMEGPDFRHG PPSTPLPPAQ DDTMSWCSQQ DTMSSTGCSP GPRKRKSRKP
510 520 530 540 550
SLCQDPHTSS TDGSGDRNPL SEPLLAEERP PCGPSVAPLK RADGRLGEAE
560 570 580 590 600
GARGACEPFL AQARLAWEAQ QVHHHMKQRS SWDSQKDGSG YESDGAVPLP
610 620 630 640 650
MPGPVVRAFS EDEALAQQES KHWKRSTFEK LGFPQILLEK SISVQTNLAS
660 670 680 690 700
PEPYLHPSQS EDLGSCAQFE SGRQGRSMVP SASCVFPAFT LRKPSSETDI
710 720 730 740 750
ENWASKHFNK HTQGLFRRKV SIANMLAWSS ESIKKPMIMT SDRHVKKEAC
760 770 780 790 800
EIFKLIQMYM GDRRAKADPL HVALEVATKG WSTQGLRDEL YIQLCRQTTE
810 820 830 840 850
NFRLESLARG WELMAICLAF FPPTPKFHSY LEGYIYRHMD PVNDTKVTQH
860 870 880 890 900
IKELLERNTK KKSKLRKKPK PYVEEPDGVA ISTYAKYCYH KLQKAALTGA
910 920 930 940 950
KKGLRKPTVE EIRHAKNAVF SPSMFGSALQ EVMSMQKERY PERQLPWVQT
960 970 980 990 1000
RLSEEVLALN GDQTEGIFRV PGDIDEVNAL KLQVDQWKVP TGLEDPHVPA
1010 1020 1030 1040 1050
SLLKLWYREL EEPLIPHEFY DQCIAHYESP EAAVAVVHAL PRINRMVLCY
1060 1070 1080 1090 1100
LIRFLQVFVQ PANVAITKMD VSNLAMVMAP NCLRCQSDDP RVIFENTRKE
1110 1120
MSFLRVLIQH LDTSFMEGVL
Length:1,120
Mass (Da):126,103
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6A81233D5C073B37
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3T3V9G3T3V9_LOXAF
Rho GTPase activating protein 39
ARHGAP39
1,094Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLAFT00000027760; ENSLAFP00000025027; ENSLAFG00000009522

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9785.ENSLAFP00000025027

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSLAFT00000027760; ENSLAFP00000025027; ENSLAFG00000009522

Phylogenomic databases

eggNOGiENOG410IG4K Eukaryota
ENOG410XQ23 LUCA
GeneTreeiENSGT00390000003161
InParanoidiG3UB19
OMAiDEVNCMK
TreeFamiTF323577

Family and domain databases

Gene3Di1.10.555.10, 1 hit
1.25.40.530, 1 hit
InterProiView protein in InterPro
IPR000857 MyTH4_dom
IPR038185 MyTH4_dom_sf
IPR008936 Rho_GTPase_activation_prot
IPR000198 RhoGAP_dom
IPR001202 WW_dom
IPR036020 WW_dom_sf
PfamiView protein in Pfam
PF00784 MyTH4, 1 hit
PF00620 RhoGAP, 1 hit
SMARTiView protein in SMART
SM00139 MyTH4, 1 hit
SM00324 RhoGAP, 1 hit
SM00456 WW, 2 hits
SUPFAMiSSF48350 SSF48350, 1 hit
SSF51045 SSF51045, 1 hit
PROSITEiView protein in PROSITE
PS51016 MYTH4, 1 hit
PS50238 RHOGAP, 1 hit
PS50020 WW_DOMAIN_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3UB19_LOXAF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3UB19
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 5, 2019
This is version 32 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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