INS

Functionⁱ

Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.UniRule annotationARBA annotation

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW
identical protein binding Source: Ensembl
insulin-like growth factor receptor binding Source: Ensembl
insulin receptor binding Source: Ensembl
protease binding Source: Ensembl

Complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of protein kinase B activity Source: Ensembl
acute-phase response Source: Ensembl
alpha-beta T cell activation Source: Ensembl
fatty acid homeostasis Source: Ensembl
glucose homeostasis Source: Ensembl
glucose metabolic process Source: UniProtKB-UniRule
G protein-coupled receptor signaling pathway Source: Ensembl
insulin receptor signaling pathway Source: Ensembl
negative regulation of acute inflammatory response Source: Ensembl
negative regulation of fatty acid metabolic process Source: Ensembl
negative regulation of feeding behavior Source: Ensembl
negative regulation of glycogen catabolic process Source: Ensembl
negative regulation of lipid catabolic process Source: Ensembl
negative regulation of NAD(P)H oxidase activity Source: Ensembl
negative regulation of protein catabolic process Source: Ensembl
negative regulation of protein secretion Source: Ensembl
negative regulation of proteolysis Source: Ensembl
negative regulation of reactive oxygen species biosynthetic process Source: Ensembl
negative regulation of respiratory burst involved in inflammatory response Source: Ensembl
neuron projection maintenance Source: Ensembl
positive regulation of cell population proliferation Source: Ensembl
positive regulation of cytokine production Source: Ensembl
positive regulation of dendritic spine maintenance Source: Ensembl
positive regulation of glucose import Source: Ensembl
positive regulation of glycogen biosynthetic process Source: Ensembl
positive regulation of glycolytic process Source: Ensembl
positive regulation of insulin receptor signaling pathway Source: Ensembl
positive regulation of MAPK cascade Source: Ensembl
positive regulation of mitotic nuclear division Source: Ensembl
positive regulation of NF-kappaB transcription factor activity Source: Ensembl
positive regulation of nitric oxide mediated signal transduction Source: Ensembl
positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
positive regulation of protein kinase B signaling Source: Ensembl
positive regulation of protein localization to nucleus Source: Ensembl
positive regulation of respiratory burst Source: Ensembl
regulation of cellular amino acid metabolic process Source: Ensembl
regulation of protein localization to plasma membrane Source: Ensembl
regulation of transmembrane transporter activity Source: Ensembl
wound healing Source: Ensembl

Complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	HormoneUniRule annotationARBA annotation
Biological process	Carbohydrate metabolism, Glucose metabolismUniRule annotationARBA annotation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: InsulinUniRule annotation
Gene namesⁱ	Name:INSImported
Organismⁱ	Loxodonta africana (African elephant)Imported
Taxonomic identifierⁱ	9785 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Afrotheria › Proboscidea › Elephantidae › Loxodonta
Proteomesⁱ	UP000007646 Componentⁱ: Unassembled WGS sequence

Keywords - Cellular componentⁱ

SecretedUniRule annotationARBA annotation

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST		24
ChainⁱPRO_5003455639	25 – 105	InsulinSequence analysisAdd BLAST		81

Keywords - PTMⁱ

Disulfide bondARBA annotation

Interactionⁱ

Subunit structureⁱ

Heterodimer of a B chain and an A chain linked by two disulfide bonds.

UniRule annotation

GO - Molecular functionⁱ

hormone activity Source: UniProtKB-KW
identical protein binding Source: Ensembl
insulin-like growth factor receptor binding Source: Ensembl
insulin receptor binding Source: Ensembl
protease binding Source: Ensembl

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	9785.ENSLAFP00000015739

STRINGⁱ

9785.ENSLAFP00000015739

Structureⁱ

3D structure databases

SMRⁱ	G3TLG9
ModBaseⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 104	IlGFInterPro annotationAdd BLAST		77

Sequence similaritiesⁱ

Belongs to the insulin family.UniRule annotationARBA annotation

Keywords - Domainⁱ

SignalSequence analysis

Phylogenomic databases

eggNOGⁱ	ENOG502S5P5, Eukaryota
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000015440
HOGENOMⁱ	CLU_140421_1_0_1
InParanoidⁱ	G3TLG9
OMAⁱ	APPQHLC
Database of Orthologous Groups More...OrthoDBⁱ	1644517at2759
TreeFamⁱ	TF332820

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd04367, IlGF_insulin_like, 1 hit
InterProⁱ	View protein in InterPro IPR004825, Insulin IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family
PANTHERⁱ	PTHR11454, PTHR11454, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00049, Insulin, 1 hit
PRINTSⁱ	PR00277, INSULIN PR00276, INSULINFAMLY
SMARTⁱ	View protein in SMART SM00078, IlGF, 1 hit
SUPFAMⁱ	SSF56994, SSF56994, 1 hit
PROSITEⁱ	View protein in PROSITE PS00262, INSULIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

G3TLG9-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MALWTRLLPL LALLAVGAPP PARAFVNQHL CGSHLVEALY LVCGERGFFY 
        60         70         80         90        100
TPKTRREVED TQVGEVELGT GLQPFPAEAP KQKRGIVEQC CTGVCSLYQL 

ENYCN

Length:105

Mass (Da):11,593

Last modified:November 16, 2011 - v1

Checksum:ⁱCBF5AD5CFA402735

GO

Sequence databases

NCBI Reference Sequences More...RefSeqⁱ	XP_003422420.1, XM_003422372.1

RefSeqⁱ

XP_003422420.1, XM_003422372.1

Genome annotation databases

Ensemblⁱ	ENSLAFT00000020965; ENSLAFP00000015739; ENSLAFG00000020914
GeneIDⁱ	100661112
KEGGⁱ	lav:100661112

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
G3TLG9	Insulin		Florida manatee		106	UniRef90_G3TLG9

Protein	Similar proteins		Species	Score	Length	Source
G3TLG9	Insulin	)	BOVIN		105	UniRef50_P01317
Insulin		PANBU		110
Insulin-1		XENLA		106
Insulin		SHEEP		105
Insulin		CAPHI		105
+66

Cross-referencesⁱ

Sequence databases

RefSeqⁱ	XP_003422420.1, XM_003422372.1

RefSeqⁱ

XP_003422420.1, XM_003422372.1

3D structure databases

SMRⁱ	G3TLG9
ModBaseⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9785.ENSLAFP00000015739

STRINGⁱ

9785.ENSLAFP00000015739

Genome annotation databases

Ensemblⁱ	ENSLAFT00000020965; ENSLAFP00000015739; ENSLAFG00000020914
GeneIDⁱ	100661112
KEGGⁱ	lav:100661112

Organism-specific databases

CTDⁱ	3630

CTDⁱ

3630

Phylogenomic databases

eggNOGⁱ	ENOG502S5P5, Eukaryota
GeneTreeⁱ	ENSGT00390000015440
HOGENOMⁱ	CLU_140421_1_0_1
InParanoidⁱ	G3TLG9
OMAⁱ	APPQHLC
OrthoDBⁱ	1644517at2759
TreeFamⁱ	TF332820

Family and domain databases

CDDⁱ	cd04367, IlGF_insulin_like, 1 hit
InterProⁱ	View protein in InterPro IPR004825, Insulin IPR016179, Insulin-like IPR036438, Insulin-like_sf IPR022353, Insulin_CS IPR022352, Insulin_family
PANTHERⁱ	PTHR11454, PTHR11454, 1 hit
Pfamⁱ	View protein in Pfam PF00049, Insulin, 1 hit
PRINTSⁱ	PR00277, INSULIN PR00276, INSULINFAMLY
SMARTⁱ	View protein in SMART SM00078, IlGF, 1 hit
SUPFAMⁱ	SSF56994, SSF56994, 1 hit
PROSITEⁱ	View protein in PROSITE PS00262, INSULIN, 1 hit
ProtoNetⁱ	Search...
MobiDBⁱ	Search...

Entry informationⁱ

Entry nameⁱ	G3TLG9_LOXAF
Accessionⁱ	G3TLG9Primary (citable) accession number: G3TLG9
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	November 16, 2011
	Last sequence update:	November 16, 2011
	Last modified:	February 10, 2021
	This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Reference proteomeImported

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - G3TLG9 (G3TLG9_LOXAF)

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Insulin

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Keywords - PTMi

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ