UniProtKB - G3TFE5 (G3TFE5_LOXAF)
Protein
Submitted name:
Myocyte enhancer factor 2D
Gene
MEF2D
Organism
Loxodonta africana (African elephant)
Status
Functioni
GO - Molecular functioni
- activating transcription factor binding Source: Ensembl
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- histone deacetylase binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- adult heart development Source: Ensembl
- chondrocyte differentiation Source: Ensembl
- endochondral ossification Source: Ensembl
- osteoblast differentiation Source: Ensembl
- positive regulation of vascular associated smooth muscle cell proliferation Source: Ensembl
- skeletal muscle cell differentiation Source: Ensembl
Keywordsi
Molecular function | ActivatorARBA annotation, DNA-bindingARBA annotation |
Biological process | Transcription, Transcription regulationARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: Myocyte enhancer factor 2DImported |
Gene namesi | Name:MEF2DImported |
Organismi | Loxodonta africana (African elephant)Imported |
Taxonomic identifieri | 9785 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Afrotheria › Proboscidea › Elephantidae › Loxodonta |
Proteomesi |
|
Subcellular locationi
Nucleus
- Nucleus ARBA annotation
Nucleus
- nucleoplasm Source: Ensembl
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationInteractioni
GO - Molecular functioni
- activating transcription factor binding Source: Ensembl
- histone deacetylase binding Source: Ensembl
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: Ensembl
Protein-protein interaction databases
STRINGi | 9785.ENSLAFP00000013044 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 1 – 61 | MADS-boxInterPro annotationAdd BLAST | 61 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 174 – 207 | DisorderedSequence analysisAdd BLAST | 34 | |
Regioni | 245 – 266 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 357 – 413 | DisorderedSequence analysisAdd BLAST | 57 | |
Regioni | 434 – 506 | DisorderedSequence analysisAdd BLAST | 73 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 174 – 196 | PolarSequence analysisAdd BLAST | 23 | |
Compositional biasi | 369 – 401 | Pro-richSequence analysisAdd BLAST | 33 | |
Compositional biasi | 444 – 458 | Pro-richSequence analysisAdd BLAST | 15 |
Phylogenomic databases
eggNOGi | KOG0014, Eukaryota |
GeneTreei | ENSGT00940000159463 |
HOGENOMi | CLU_022902_4_0_1 |
InParanoidi | G3TFE5 |
OMAi | NADIIEX |
TreeFami | TF314067 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
G3TFE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGRKKIQIQR ITDERNRQVT FTKRKFGLMK KAYELSVLCD CEIALIIFNH
60 70 80 90 100
SNKLFQYAST DMDKVLLKYT EYNEPHESRT NADIIETLRK KGFNGCDSPE
110 120 130 140 150
PDGEDSLEQS PLLEDKYRRA SEELDGLFRR YGSAVPAPNF AMPVTVPVSN
160 170 180 190 200
QSSLQFSNPS SSLVTPSLVT SSLTDPRLLS PQQPALQRNS VSPGLPQRPA
210 220 230 240 250
SAGAMLGGDL SSANGACPSP VGNGYVSARA SPGLLPVANG NSLNKVIPAK
260 270 280 290 300
SPPPPTHSAQ LGAPSRKPDL RVITSQGGKG LMHHLTEDHL DLNNAQRLGV
310 320 330 340 350
SQSTHSLTTP VVSVATPSLL SQGLPFSSMP TAYNTDYQLT SAELSSLPAF
360 370 380 390 400
SSPGGLSLGN VTAWQQPQQP QQPPQPQPPQ PQPQPQQPQQ PQPPQQPPQQ
410 420 430 440 450
QPHLVPVSLG NLIPGSPLPH VGAALTVTTH PHISIKSEPV SPSRERSPAP
460 470 480 490 500
PPPAVFPAAR AEPGDGLSSP AGGSYETGDR DDGRGDFGPT LGLLRPAPEQ
510
EAEGSAVKRM RLDTWVL
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3U2P4 | G3U2P4_LOXAF | Myocyte enhancer factor 2D | MEF2D | 511 | Annotation score: |
Genome annotation databases
Ensembli | ENSLAFT00000015564; ENSLAFP00000013044; ENSLAFG00000015564 |
Similar proteinsi
Cross-referencesi
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9785.ENSLAFP00000013044 |
Genome annotation databases
Ensembli | ENSLAFT00000015564; ENSLAFP00000013044; ENSLAFG00000015564 |
Phylogenomic databases
eggNOGi | KOG0014, Eukaryota |
GeneTreei | ENSGT00940000159463 |
HOGENOMi | CLU_022902_4_0_1 |
InParanoidi | G3TFE5 |
OMAi | NADIIEX |
TreeFami | TF314067 |
Family and domain databases
CDDi | cd00265, MADS_MEF2_like, 1 hit |
Gene3Di | 3.40.1810.10, 1 hit |
InterProi | View protein in InterPro IPR022102, HJURP_C IPR033896, MADS_MEF2-like IPR002100, TF_MADSbox IPR036879, TF_MADSbox_sf |
Pfami | View protein in Pfam PF12347, HJURP_C, 1 hit PF00319, SRF-TF, 1 hit |
PRINTSi | PR00404, MADSDOMAIN |
SMARTi | View protein in SMART SM00432, MADS, 1 hit |
SUPFAMi | SSF55455, SSF55455, 1 hit |
PROSITEi | View protein in PROSITE PS00350, MADS_BOX_1, 1 hit PS50066, MADS_BOX_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3TFE5_LOXAF | |
Accessioni | G3TFE5Primary (citable) accession number: G3TFE5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | October 7, 2020 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |