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Entry version 45 (05 Jun 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

SLC5A4

Organism
Loxodonta africana (African elephant)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC5A4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLoxodonta africana (African elephant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9785 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei29 – 48HelicalSequence analysisAdd BLAST20
Transmembranei69 – 97HelicalSequence analysisAdd BLAST29
Transmembranei103 – 121HelicalSequence analysisAdd BLAST19
Transmembranei141 – 158HelicalSequence analysisAdd BLAST18
Transmembranei178 – 202HelicalSequence analysisAdd BLAST25
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Transmembranei274 – 292HelicalSequence analysisAdd BLAST19
Transmembranei312 – 334HelicalSequence analysisAdd BLAST23
Transmembranei381 – 401HelicalSequence analysisAdd BLAST21
Transmembranei422 – 443HelicalSequence analysisAdd BLAST22
Transmembranei455 – 477HelicalSequence analysisAdd BLAST23
Transmembranei484 – 506HelicalSequence analysisAdd BLAST23
Transmembranei526 – 547HelicalSequence analysisAdd BLAST22
Transmembranei635 – 658HelicalSequence analysisAdd BLAST24

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9785.ENSLAFP00000008369

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni574 – 594DisorderedSequence analysisAdd BLAST21

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IP49 Eukaryota
COG4146 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160846

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3T4R8

KEGG Orthology (KO)

More...
KOi
K14384

Identification of Orthologs from Complete Genome Data

More...
OMAi
CYTPQAD

Database of Orthologous Groups

More...
OrthoDBi
243316at2759

TreeFam database of animal gene trees

More...
TreeFami
TF352855

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1730.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00474 SSF, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00813 sss, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3T4R8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASTLSPSTT TGASEQPVMS ERIQNAADIS VIVIYFVVVM VVGLWAMLKT
60 70 80 90 100
NRSTIGGFFL AGRDMTWCPM GASLFASNIG SGHFVGLAGT GAASGIAVAA
110 120 130 140 150
FEWNAALLLP ALGWIFVPIY IKAGVMTMPE YLRKRFGGKR LQIYLSILTV
160 170 180 190 200
LICVILRISS DILSGAIFIK LALGLDLYVA IIALLAITAV YTITGGLASV
210 220 230 240 250
IYTDTLQTIV MLIGSFILMG FAFAEVGGYE SFTEKYMNAI PSVVEGDNLT
260 270 280 290 300
VSSTCYTPGP DSFHIFQDAV TGNIPWPGTI LGMTILASWY WCTDQVIVQR
310 320 330 340 350
CLSGKNMSHV KAACVVCGYL KLLPLFLMVM PGMISRILYT DKVACVIPSE
360 370 380 390 400
CMKHCDTEIG CTNYAYPTLV LELMPNGLRG LMLSVMLASL MSSLTSIFNS
410 420 430 440 450
ASTLFTMDLY TKIRKQASEK ELLIAGRLFI ILLIIISIVW VPLVQVAQNG
460 470 480 490 500
QLFHYIESVS SYLGPPIAAV FLLAIFCKRV NEQGAFWGLI VGLVIGLIRM
510 520 530 540 550
IAEFAYGTGS CIAASDCPEF ICGVHYLYFA IILFFVSILI ILGVSLITKP
560 570 580 590 600
IPDVHLHGLC WALRNSTEER IDLDAEDKRQ EEVDDSEEDN SEETRGCFKK
610 620 630 640 650
AYDLFCGLQK KGPKLTKEEK EALEKRLKDT SEKPLWRTVV NINGILLLAV

TVFVHGYYA
Length:659
Mass (Da):72,115
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE9CCC406E69A21AF
GO

Sequence databases

NCBI Reference Sequences

More...
RefSeqi
XP_003419232.1, XM_003419184.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLAFT00000009991; ENSLAFP00000008369; ENSLAFG00000009992

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
100674370

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
lav:100674370

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

RefSeqiXP_003419232.1, XM_003419184.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9785.ENSLAFP00000008369

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSLAFT00000009991; ENSLAFP00000008369; ENSLAFG00000009992
GeneIDi100674370
KEGGilav:100674370

Phylogenomic databases

eggNOGiENOG410IP49 Eukaryota
COG4146 LUCA
GeneTreeiENSGT00940000160846
InParanoidiG3T4R8
KOiK14384
OMAiCYTPQAD
OrthoDBi243316at2759
TreeFamiTF352855

Family and domain databases

Gene3Di1.20.1730.10, 1 hit
InterProiView protein in InterPro
IPR038377 Na/Glc_symporter_sf
IPR001734 Na/solute_symporter
IPR018212 Na/solute_symporter_CS
PfamiView protein in Pfam
PF00474 SSF, 1 hit
TIGRFAMsiTIGR00813 sss, 1 hit
PROSITEiView protein in PROSITE
PS00456 NA_SOLUT_SYMP_1, 1 hit
PS00457 NA_SOLUT_SYMP_2, 1 hit
PS50283 NA_SOLUT_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3T4R8_LOXAF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3T4R8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 5, 2019
This is version 45 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
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