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Entry version 39 (17 Jun 2020)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Myelin regulatory factor

Gene

MYRF

Organism
Loxodonta africana (African elephant)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Myelin regulatory factorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:MYRFImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLoxodonta africana (African elephant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9785 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei713 – 738HelicalSequence analysisAdd BLAST26
Transmembranei789 – 811HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9785.ENSLAFP00000003471

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini621 – 651MRF_C1InterPro annotationAdd BLAST31
Domaini951 – 1085MRF_C2InterPro annotationAdd BLAST135

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni37 – 326DisorderedSequence analysisAdd BLAST290
Regioni675 – 697DisorderedSequence analysisAdd BLAST23
Regioni831 – 950DisorderedSequence analysisAdd BLAST120

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi99 – 121Pro-richSequence analysisAdd BLAST23
Compositional biasi126 – 143PolarSequence analysisAdd BLAST18
Compositional biasi159 – 185Pro-richSequence analysisAdd BLAST27
Compositional biasi247 – 261PolarSequence analysisAdd BLAST15
Compositional biasi271 – 291Pro-richSequence analysisAdd BLAST21
Compositional biasi933 – 950PolarSequence analysisAdd BLAST18

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3661 Eukaryota
ENOG410XPRK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063626

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3STR5

TreeFam database of animal gene trees

More...
TreeFami
TF312888

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026933 MRF
IPR026932 MRF_C1
IPR025719 MRF_C2

The PANTHER Classification System

More...
PANTHERi
PTHR13029:SF16 PTHR13029:SF16, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13887 MRF_C1, 1 hit
PF13888 MRF_C2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3STR5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GHDINGALEP SNIDTSILEE YISKEDASDL CFPDISAPAH AASYPHGQPA
60 70 80 90 100
IPGSSGVHHL SPPGGGPSPG RHGPLPTPSY GAPLNCNNNN GMGAAPKPFL
110 120 130 140 150
GGPGPPIKAE PKAPYAPGTL PDSPPDSGSE AYSPQQVNDP HLLRTLTPET
160 170 180 190 200
LCHVGVPSRL EHPPPPPAHL PGPPPPPPPP PHYPVLQRDL YMKAEPPVPT
210 220 230 240 250
YGAMGQGLAP ADLHHTQQSQ MLHQLLQHHG AELPTHPSKK RKHSESPPNT
260 270 280 290 300
LNAQMLNGMI KQEPGTMTAL PPHPARAPSP PWPPQGPLSP GPGSLPLSIA
310 320 330 340 350
RVQTPPWHPP GAPSPGLLQD SDSLSGSYLD PNYQSIKWQP HQQNKWATLY
360 370 380 390 400
DANYKELPML TYRVDVYIGM LGEPNVKTPE GLKPLDCFFL KLHGVKAGLG
410 420 430 440 450
TQQGGQGRRT RKAWGVERPQ GEVSVLVPLL AFSPAPRSST VSPMGFAVCP
460 470 480 490 500
PEHYVIPPFF FPLSPPCLSD HSSFYSGSLL ILHLRHPGRL LGPEPILWIH
510 520 530 540 550
TSLPSDSTAT VHGVGGMMSE RPDVLLLKNQ PLQSLWTAVL VSHTRGRHES
560 570 580 590 600
QSTQWQLFFV VVVRTFVYLG RGDSLAQGQG DFEAVTKVVG SRAPLLLPAG
610 620 630 640 650
VTAFAARAGC ALNPGPRPRQ ERIFMENVGA VKELCKLTDN LETRIDELER
660 670 680 690 700
WSHKLAKLRR LDSVKSSGSS GAFSHAGSQF SRAGSVPHKK RAPKVASKSS
710 720 730 740 750
SVAPDQACIS QRFLQGTIIA LVVVMAFSVV SMSTLYVLSL RTEEDLVDTD
760 770 780 790 800
GPFAVSTSCL LALLRPQHPG GSEAMCPWYV SGPSAPSCFW LLLFSFLPSL
810 820 830 840 850
STPLLFLLLL WDCRAHTATC RCPLGSASSL SSSPPLPPAG SQPRSFGTHA
860 870 880 890 900
ASTRPPVTRG GWPGHTGPSF AARVRAQGQG WGASAAPFHX HPKSLEPVAS
910 920 930 940 950
PVVPFPGGQS KAKNSPNLGL HGRARRGALQ PSLGPARSTQ TQGQPDPMPS
960 970 980 990 1000
LTSIQVLENA MPITSQYCAP GHACRPGNFT YHIPVSSSTP LHLSLTLQMN
1010 1020 1030 1040 1050
SSSPVSVVLC SLTSEEEPCE EGGFPQSLPT HQNTQGTSHQ WPVTILSFRE
1060 1070 1080
FTYHFRVALL GQANCSAEAL VQPVTDYHFH FYRLCD
Length:1,086
Mass (Da):116,345
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE6971183B77328AC
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UG08G3UG08_LOXAF
Myelin regulatory factor
MYRF
761Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLAFT00000004164; ENSLAFP00000003471; ENSLAFG00000004162

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

Protein-protein interaction databases

STRINGi9785.ENSLAFP00000003471

Genome annotation databases

EnsembliENSLAFT00000004164; ENSLAFP00000003471; ENSLAFG00000004162

Phylogenomic databases

eggNOGiKOG3661 Eukaryota
ENOG410XPRK LUCA
GeneTreeiENSGT00530000063626
InParanoidiG3STR5
TreeFamiTF312888

Family and domain databases

InterProiView protein in InterPro
IPR026933 MRF
IPR026932 MRF_C1
IPR025719 MRF_C2
PANTHERiPTHR13029:SF16 PTHR13029:SF16, 3 hits
PfamiView protein in Pfam
PF13887 MRF_C1, 1 hit
PF13888 MRF_C2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3STR5_LOXAF
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3STR5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 17, 2020
This is version 39 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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