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Entry version 50 (05 Jun 2019)
Sequence version 1 (16 Nov 2011)
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Protein
Submitted name:

Uncharacterized protein

Gene

DOCK11

Organism
Loxodonta africana (African elephant)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:DOCK11Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiLoxodonta africana (African elephant)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9785 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007646 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9785.ENSLAFP00000002103

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 241PHInterPro annotationAdd BLAST108
Domaini609 – 787DHR-1InterPro annotationAdd BLAST179
Domaini1578 – 2005DHR-2InterPro annotationAdd BLAST428

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1197 – 1236DisorderedSequence analysisAdd BLAST40

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1220 – 1236PolarSequence analysisAdd BLAST17

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DOCK family.PROSITE-ProRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1997 Eukaryota
ENOG410XNVY LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155658

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3SQL8

Identification of Orthologs from Complete Genome Data

More...
OMAi
LGQVGDN

TreeFam database of animal gene trees

More...
TreeFami
TF313629

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08697 C2_Dock-D, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.30.29.30, 1 hit
2.60.40.150, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain

The PANTHER Classification System

More...
PANTHERi
PTHR23317 PTHR23317, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233 PH, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3SQL8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
LIKEKTKVVE PLDYENVVTQ RKTQIYSDPL RDLLMFPMED ISISVISRQR
60 70 80 90 100
RTMQSTVPED AEKRAQSLFV KECIKTYSTD WHVVNYKYEE FSGDFRMLPC
110 120 130 140 150
KSLRPEKIPN HVFEIDEDCE KDEDSSSLCS QKGGVIKQGW LHKANVNSTI
160 170 180 190 200
SVSMKVFKRR YFYLTQLPDG SYILNSYKDE KNSKESKGCI YLDACIDVVQ
210 220 230 240 250
CPKMRRHGFE LKMLDKYSHY LAAETEQEME EWLITLKKII QINTDSLVQE
260 270 280 290 300
KKETVETAQD DETGSQGKAE NIMASLERSM HPELMKYGRE TEQLNKLSRG
310 320 330 340 350
DGRQNLFSFD SEVQRLDFSG IEPDIKPFEE KCNKRFLVNC HDLTFNILGQ
360 370 380 390 400
VGDNAKGPPT NVEPFFINLA VFDVKNNCKI SADFHVDLNP PSVREMLWGT
410 420 430 440 450
SAQLASDGNP KGSSPESFIH GIAESQLRYV KQGIFSVMNP HPEIFLVARI
460 470 480 490 500
EKVLQGNITH CAEPYIKNSD PVKTAQKVHR TAKQVCSRLG QYRMPFAWAA
510 520 530 540 550
RPIFKDTQGS LDLEGKVSPL YKQDSSKLSN EDILKLLSEY KKPEKTKLQI
560 570 580 590 600
IPGQLNITVE CVPVDLSNCI TSSYVPLKPF EKNCQNITVE VEEFVPEMTK
610 620 630 640 650
YCSPFTVYTN HLYVYPLQLK YDSQKTFAKA RNIAVCVEFR DSDESDASAL
660 670 680 690 700
KCIYGKPAGS VFTTNAYAVV SHHNQNPEFY DEVKIELPIY LHQKHHLLFT
710 720 730 740 750
FYHVSCEINT KGTTKKQDTV ETPVGFAWVP LLKDGRIITF EQQLPVSANL
760 770 780 790 800
PPGYLNLNDA ESRRQSSVDI KWVDGAKPLL KVKSHLESTI YTQDLHVHKF
810 820 830 840 850
FHHCQLIQSG SKEVPGELIK YLKCLHAMEI QVMIQFLPVI LMQLFRVLTN
860 870 880 890 900
MTHEDDVPIN CTMVLLHIVS KCHEEGLDNY LRSFIKYSFR PEKPSAPQAQ
910 920 930 940 950
LIHETLATTM IAILKQSADF LAINKLLKYS WFFFEIIAKS MATYLLEENK
960 970 980 990 1000
IKLPRGQRFP EAYHHVLHSL LLAIIPHVTI RYAEIPDESR NVNYSLASFL
1010 1020 1030 1040 1050
KRCLTLMDRG FVFNLINDYI SGFSPKDPKV LAEYKFEFLQ TICNHEHYIP
1060 1070 1080 1090 1100
LNLPMAFAKP KLQRVQDSNL EYSLSDEYCK HHFLVGLLLR ETSIALQDNY
1110 1120 1130 1140 1150
EIRYTAISVI KNLLIKHAFD TRYQHKNQQA KIAQLYLPFV GLLLENIQRL
1160 1170 1180 1190 1200
AGRDTLYSCA AMPSSASRDE FACGFTSPTS RGSLSADKDT VYGSFQNGHG
1210 1220 1230 1240 1250
IKREDSRGSL IPEGATGFPD QGNTGENTRQ SSTRSSVSQY NRLDQCEIRS
1260 1270 1280 1290 1300
LLMCYLYIIK MISEDTLLTY WNKVSPQELI NILILLEVCL FHFRYMGKRN
1310 1320 1330 1340 1350
IARVHDAWLS KHLGIDRKSQ TMPALRNRSG VMQARLQHLS SLESSFTLNH
1360 1370 1380 1390 1400
SSTTTEADIF HQALLEGNTA TEVSLTVLDT ISFFTQCFKT QLLNNDGHNP
1410 1420 1430 1440 1450
LMKKVFDIHL AFLKNGQSEV SLKHVFASLR AFISKFPSAF FKGRVNMCAA
1460 1470 1480 1490 1500
FCYEVLKCCT SKISSTRNEA SALLYLLMRN NFEYTKRKTF LRTHLQIIIA
1510 1520 1530 1540 1550
VSQLIADVAL SGGSRFQESL FIINNFANSD RPMKATAFPT EVKDLTKRIR
1560 1570 1580 1590 1600
TVLMATAQMK EHEKDPEMLI DLQYSLAKSY ASTPELRKTW LDSMAKIHIK
1610 1620 1630 1640 1650
NGDLSEAAMC YVHVAALVAE FLHRKKLFPN GCSAFKKITP NIDEEGAMKE
1660 1670 1680 1690 1700
DAGMMDVHYS EEILLELLEQ CVDGLWKAER YEVISEISKL IIPIYEKRRE
1710 1720 1730 1740 1750
FEKLTQIYRT LHGAYTKILE VMQTKKRLLG TFFRVAFYGQ SFFEEEDGKE
1760 1770 1780 1790 1800
YIYKEPKLTG LSEISLRLVK LYGEKFGTEN VKIIQDSDKV NTKELDPKYA
1810 1820 1830 1840 1850
YIQVTYVKPY FDDRELTERK TEFERNHNIT RFVFEAPYTL SGKKQGCIEE
1860 1870 1880 1890 1900
QCKRRTILTT SNSFPYVKKR IPINYEQQIN LKPIDVATDE IKDKTAELQK
1910 1920 1930 1940 1950
LCSSADVDMI QLQLKLQGCV SVQVNAGPLA YARTFLNDSQ ASKYPPKKVN
1960 1970 1980 1990 2000
ELKDMFRKFI QACSIALELN ERLIKEDQVE YHEGLKSNFR DMVKELSDII
2010 2020 2030 2040
HEQILQEDTM HSPWMSNTLH VFCAISGTSS DRGYGSPRYA
Length:2,040
Mass (Da):233,998
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4FABD5C0DDC68359
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UBZ3G3UBZ3_LOXAF
Uncharacterized protein
DOCK11
322Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSLAFT00000002516; ENSLAFP00000002103; ENSLAFG00000002510

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9785.ENSLAFP00000002103

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSLAFT00000002516; ENSLAFP00000002103; ENSLAFG00000002510

Phylogenomic databases

eggNOGiKOG1997 Eukaryota
ENOG410XNVY LUCA
GeneTreeiENSGT00940000155658
InParanoidiG3SQL8
OMAiLGQVGDN
TreeFamiTF313629

Family and domain databases

CDDicd08697 C2_Dock-D, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 1 hit
InterProiView protein in InterPro
IPR037809 C2_Dock-D
IPR035892 C2_domain_sf
IPR027007 DHR-1_domain
IPR027357 DHR-2
IPR026791 DOCK
IPR010703 DOCK_C
IPR021816 DOCK_C/D_N
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
PANTHERiPTHR23317 PTHR23317, 1 hit
PfamiView protein in Pfam
PF06920 DHR-2, 1 hit
PF14429 DOCK-C2, 1 hit
PF11878 DUF3398, 1 hit
PF00169 PH, 1 hit
SMARTiView protein in SMART
SM00233 PH, 1 hit
PROSITEiView protein in PROSITE
PS51650 DHR_1, 1 hit
PS51651 DHR_2, 1 hit
PS50003 PH_DOMAIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3SQL8_LOXAF
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3SQL8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: June 5, 2019
This is version 50 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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