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Protein

Dihydropyrimidine dehydrogenase [NADP(+)]

Gene

DPYD

Organism
Loxodonta africana (African elephant)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine.UniRule annotation

Catalytic activityi

5,6-dihydrouracil + NADP+ = uracil + NADPH.UniRule annotation

Cofactori

Protein has several cofactor binding sites:

Pathwayi: beta-alanine biosynthesis

This protein is involved in the pathway beta-alanine biosynthesis, which is part of Amino-acid biosynthesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway beta-alanine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotation
Ligand4Fe-4SUniRule annotation, FADUniRule annotation, Flavoprotein, FMNUniRule annotation, Iron, Iron-sulfur, Metal-binding, NADPUniRule annotation

Enzyme and pathway databases

UniPathwayi
UPA00131

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydropyrimidine dehydrogenase [NADP(+)]UniRule annotation (EC:1.3.1.2UniRule annotation)
Short name:
DHPDHaseUniRule annotation
Short name:
DPDUniRule annotation
Alternative name(s):
Dihydrothymine dehydrogenaseUniRule annotation
Dihydrouracil dehydrogenaseUniRule annotation
Gene namesi
Name:DPYDImported
OrganismiLoxodonta africana (African elephant)Imported
Taxonomic identifieri9785 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaAfrotheriaProboscideaElephantidaeLoxodonta
Proteomesi
  • UP000007646 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9785.ENSLAFP00000001505

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 1004Fe-4S ferredoxin-typeInterPro annotationAdd BLAST32
Domaini944 – 9764Fe-4S ferredoxin-typeInterPro annotationAdd BLAST33
Domaini978 – 10074Fe-4S ferredoxin-typeInterPro annotationAdd BLAST30

Sequence similaritiesi

Belongs to the dihydropyrimidine dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiKOG0399 Eukaryota
COG0167 LUCA
COG0493 LUCA
COG1146 LUCA
GeneTreeiENSGT00500000044896
InParanoidiG3SP95
KOiK00207
OMAiEQGWGFV
OrthoDBiEOG091G00YL
TreeFamiTF105791

Family and domain databases

Gene3Di1.10.1060.10, 1 hit
3.20.20.70, 1 hit
3.50.50.60, 3 hits
InterProiView protein in InterPro
IPR017896 4Fe4S_Fe-S-bd
IPR017900 4Fe4S_Fe_S_CS
IPR013785 Aldolase_TIM
IPR005720 Dihydroorotate_DH
IPR028261 DPD_II
IPR036188 FAD/NAD-bd_sf
IPR023753 FAD/NAD-binding_dom
IPR009051 Helical_ferredxn
PfamiView protein in Pfam
PF01180 DHO_dh, 1 hit
PF14691 Fer4_20, 1 hit
PF07992 Pyr_redox_2, 1 hit
SUPFAMiSSF46548 SSF46548, 1 hit
TIGRFAMsiTIGR01037 pyrD_sub1_fam, 1 hit
PROSITEiView protein in PROSITE
PS00198 4FE4S_FER_1, 1 hit
PS51379 4FE4S_FER_2, 3 hits

Sequencei

Sequence statusi: Complete.

G3SP95-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAPVLSKDAA DIESILALNP RTQTHATLRS TAAKKLDKKH WKRNPDKNCF
60 70 80 90 100
NCEKLENNFD DIKHTTLGER GALREAMRCL KCADAPCQKS CPTNLDIKSF
110 120 130 140 150
ITSIANKNYY GAAKMIFSDN PLGLTCGMVC PTSDLCVGGC NLYATEEGPI
160 170 180 190 200
NIGGLQQFAT EVFKAMNIPQ IRNPSLPPPE KMPEAYSAKI ALFGGGPASI
210 220 230 240 250
SCASFLARLG YSDITIFEKQ EYVGGLSTSE IPQFRLPYDV VDFEIELMKD
260 270 280 290 300
LGVKIICGKS LSVNEMTLNT LKEEGYKAAF IGIGLPEANK DRIFEGLTQD
310 320 330 340 350
QGFYTSKDFL PLVAKGSKPG MCACHSPLPS IRGAVIVLGA GDTAFDCATS
360 370 380 390 400
ALRCGACRVF IVFRKGFVNI RAVPEEMELA KEEKCEFLPF LSPRKVVVKG
410 420 430 440 450
GRIVAMQFVR TEQDETGKWN EDDDQIVHLK ADVVISAFGS VLSDPKVKEA
460 470 480 490 500
LSPIKFNKWD LPEVDPETMQ TSEPWVFAGG DIVGMANTTV ESVNDGKQAS
510 520 530 540 550
WHIHKYIQSQ YGASVSAKPE LPLFCTPIDL VDISVEMAGM KFTNPFGLAS
560 570 580 590 600
ATPATSASMI RRAFEAGWGF AVTKTFSLDK DIVTNVSPRI IRGTTSGPMY
610 620 630 640 650
GPGQSSFLNI ELISEKTAAY WCQSVTELKA EFPDNIVIAS IMCSYNKNDW
660 670 680 690 700
MELSKMAEHS GADALELNLS CPHGMGERGM GLACGQDPEL VRNICRWVRQ
710 720 730 740 750
AVHVPFFAKL TPNVTDIVSI ARAAKEGGAD GVTATNTVSG LMGLNADGTP
760 770 780 790 800
WPAVGVGKRT TYGGVSGTAI RPIALRAVTS IARALPGFPV LATGGIDSAE
810 820 830 840 850
SGLQFLHSGA SVLQVCSAIQ NQDFTVIGDY CTGLKALLYL KSIEELQDWD
860 870 880 890 900
GQSPATVRHQ KGKPVPQIAE LTGKKLPSFG PYLEQRKKII AENKIRLKEQ
910 920 930 940 950
NAAFSPLERK YFVPKKPIPA IKDVIGKALK YLGMFGELSN VEQVVAMIDE
960 970 980 990 1000
EMCINCGKCY MTCNDSGYQA IQFDPETHLP TVTDSCTGCT LCLSVCPIID
1010 1020
CIRMVSRTTP YEPKRGLPLA VNPVC
Length:1,025
Mass (Da):111,302
Last modified:November 16, 2011 - v1
Checksum:i821CE42AB6E740B0
GO

Sequence databases

RefSeqiXP_010596386.1, XM_010598084.1

Genome annotation databases

EnsembliENSLAFT00000001800; ENSLAFP00000001505; ENSLAFG00000001798
GeneIDi100676827
KEGGilav:100676827

Similar proteinsi

Entry informationi

Entry nameiG3SP95_LOXAF
AccessioniPrimary (citable) accession number: G3SP95
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: November 16, 2011
Last modified: March 28, 2018
This is version 37 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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