UniProtKB - G3SKH5 (G3SKH5_GORGO)
Protein
Pendrin
Gene
SLC26A4
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Functioni
Sodium-independent transporter of chloride and iodide.UniRule annotation
GO - Molecular functioni
- anion:anion antiporter activity Source: GO_Central
- bicarbonate transmembrane transporter activity Source: GO_Central
- chloride transmembrane transporter activity Source: GO_Central
- oxalate transmembrane transporter activity Source: GO_Central
- secondary active sulfate transmembrane transporter activity Source: UniProtKB-UniRule
- sulfate transmembrane transporter activity Source: GO_Central
GO - Biological processi
- regulation of pH Source: Ensembl
- regulation of protein localization Source: Ensembl
Keywordsi
Biological process | TransportUniRule annotation |
Ligand | ChlorideUniRule annotation |
Names & Taxonomyi
Protein namesi | Recommended name: PendrinUniRule annotationAlternative name(s): Sodium-independent chloride/iodide transporterUniRule annotation Solute carrier family 26 member 4UniRule annotation |
Gene namesi | Name:SLC26A4Imported |
Organismi | Gorilla gorilla gorilla (Western lowland gorilla)Imported |
Taxonomic identifieri | 9595 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla › |
Proteomesi |
|
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Multi-pass membrane protein UniRule annotationARBA annotation
Extracellular region or secreted
- extracellular exosome Source: Ensembl
Plasma Membrane
- apical plasma membrane Source: Ensembl
- brush border membrane Source: Ensembl
- integral component of plasma membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 84 – 107 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 113 – 130 | HelicalUniRule annotationAdd BLAST | 18 | |
Transmembranei | 187 – 212 | HelicalUniRule annotationAdd BLAST | 26 | |
Transmembranei | 219 – 240 | HelicalUniRule annotationAdd BLAST | 22 | |
Transmembranei | 343 – 365 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 385 – 408 | HelicalUniRule annotationAdd BLAST | 24 | |
Transmembranei | 420 – 442 | HelicalUniRule annotationAdd BLAST | 23 | |
Transmembranei | 480 – 507 | HelicalUniRule annotationAdd BLAST | 28 |
Keywords - Cellular componenti
MembraneExpressioni
Gene expression databases
Bgeei | ENSGGOG00000034830, Expressed in adult mammalian kidney and 4 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 535 – 729 | STASInterPro annotationAdd BLAST | 195 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 749 – 769 | Sequence analysisAdd BLAST | 21 |
Sequence similaritiesi
Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]UniRule annotationARBA annotation
Keywords - Domaini
Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotationARBA annotationPhylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01000000214410 |
HOGENOMi | CLU_003182_9_4_1 |
InParanoidi | G3SKH5 |
OMAi | IQLVFGG |
OrthoDBi | 690428at2759 |
TreeFami | TF313784 |
Family and domain databases
InterProi | View protein in InterPro IPR030285, Pendrin IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF33, PTHR11814:SF33, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
TIGRFAMsi | TIGR00815, sulP, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
i Sequence
Sequence statusi: Complete.
G3SKH5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAPGGRSEP PQLPEYSCSY VVSRPVYSEL AFQQQHERRL QERKTLRESL
60 70 80 90 100
AKCCSCSRKR AFGVLKTLVP ILEWLPKYRV KEWLLSDVIS GVSTGLVATL
110 120 130 140 150
QGMAYALLAA VPVGYGLYSA FFPILTYFIF GTSRHISVGP FPVVSLMVGS
160 170 180 190 200
VVLSMAPDEH FLVSSSNGTV LNTTMIDTAA RDTARVLIAS ALTLLVGIIQ
210 220 230 240 250
LIFGGLQIGF IVRYLADPLV GGFTTAAAFQ VLVSQLKIVL NVSTKNYNGV
260 270 280 290 300
LSIIYTLVEI FQNIGDTNLA DFTAGLLTIV VCMAVKELND RFRHKIPVPI
310 320 330 340 350
PIEVIVTIIA TAISYGANLE KNYNAGIVKS IPRGFLPPEL PPVSLFSEML
360 370 380 390 400
AASFSIAVVA YAIAVSVGKV YATKYDYTVD GNQEFIAFGI SNIFSGFFSC
410 420 430 440 450
FVATTALSRT AVQESTGGKT QVAGIISAAI VMIAILALGK LLEPLQKSVL
460 470 480 490 500
AAVVIANLKG MFMQVCDIPR LWRQNKIDAV IWVFTCIVSI ILGLDLGLLA
510 520 530 540 550
GLIFGLLTVV LRVQFPSWNG LGSIPSTDIY KSTKNYKNIE EPQGVKILRF
560 570 580 590 600
SSPIFYGNVD GFKKCIKSTV GFDAIRVYNK RLKALRKIQK LIKSGQLRAT
610 620 630 640 650
KNGIISDAGS TNNAFEPDED IEDPEELDIP TKEIEIQVDW NSELPVKVNV
660 670 680 690 700
PKVPIHSLVL DCGAISFLDV VGVRSLRVIV KEFQRIDVNV YFASLQDYVI
710 720 730 740 750
EKLEQCGFFD DNIRKDTFFL TVHDAILYLQ NQVKSQEGQD SILETIALIQ
760 770 780
DCKDTLELIE TELTEEELDV QDEAMRTLAS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030054332 Genomic DNA No translation available. |
RefSeqi | XP_018885839.1, XM_019030294.1 |
Genome annotation databases
Ensembli | ENSGGOT00000041100; ENSGGOP00000028618; ENSGGOG00000034830 |
GeneIDi | 101130895 |
KEGGi | ggo:101130895 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030054332 Genomic DNA No translation available. |
RefSeqi | XP_018885839.1, XM_019030294.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 9593.ENSGGOP00000028618 |
Genome annotation databases
Ensembli | ENSGGOT00000041100; ENSGGOP00000028618; ENSGGOG00000034830 |
GeneIDi | 101130895 |
KEGGi | ggo:101130895 |
Organism-specific databases
CTDi | 5172 |
Phylogenomic databases
eggNOGi | KOG0236, Eukaryota |
GeneTreei | ENSGT01000000214410 |
HOGENOMi | CLU_003182_9_4_1 |
InParanoidi | G3SKH5 |
OMAi | IQLVFGG |
OrthoDBi | 690428at2759 |
TreeFami | TF313784 |
Gene expression databases
Bgeei | ENSGGOG00000034830, Expressed in adult mammalian kidney and 4 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR030285, Pendrin IPR018045, S04_transporter_CS IPR011547, SLC26A/SulP_dom IPR001902, SLC26A/SulP_fam IPR002645, STAS_dom IPR036513, STAS_dom_sf |
PANTHERi | PTHR11814, PTHR11814, 1 hit PTHR11814:SF33, PTHR11814:SF33, 1 hit |
Pfami | View protein in Pfam PF01740, STAS, 1 hit PF00916, Sulfate_transp, 1 hit |
SUPFAMi | SSF52091, SSF52091, 1 hit |
TIGRFAMsi | TIGR00815, sulP, 1 hit |
PROSITEi | View protein in PROSITE PS01130, SLC26A, 1 hit PS50801, STAS, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3SKH5_GORGO | |
Accessioni | G3SKH5Primary (citable) accession number: G3SKH5 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | December 2, 2020 | |
This is version 63 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |