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Protein
Submitted name:

Uromodulin

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein predictedi

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Submitted name:
UromodulinImported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 16

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

SecretedSAAS annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSGGOG00000005112 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini77 – 113EGF-likeInterPro annotationAdd BLAST37
Domaini114 – 156EGF-likeInterPro annotationAdd BLAST43
Domaini157 – 198EGF-likeInterPro annotationAdd BLAST42
Domaini383 – 638ZPInterPro annotationAdd BLAST256

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation

Phylogenomic databases

GeneTreeiENSGT00530000063244

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 2 hits
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00241 ZP, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 1 hit
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3SGQ4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRHIMTRLTL PFWLQDTRHQ RQREKFKGPT RLSFGQVLSR PEVAGRAERM
60 70 80 90 100
GQPSLTWMLM VVVASWFITT AAANTSEARW CSECHSNATC TEDEAVTTCT
110 120 130 140 150
CQEGFTGDGL TCVDLDECAI PGAHNCSANS SCVNTPGSFS CVCPEGFRLS
160 170 180 190 200
PGLGCTDVDE CAEPGLSHCH ALATCVNVVG SYLCVCPAGY RGDGWHCECS
210 220 230 240 250
PGSCGPGLDC VPEGDALVCA DPCQAHRTLD EYWRSTEYGE GYACDTDLRG
260 270 280 290 300
WYRFVGQGGA RMAETCVPVL RCNTAAPMWL NGTHPSSDEG IVSRKACAHW
310 320 330 340 350
SGHCCLWDAS VQVKACAGGY YVYNLTAPPE CHLAYCTDPS SVEGTCEECS
360 370 380 390 400
IDEDCKSNNG RWHCQCKQDF NITDISLLEH RLECGANDMK VSLGKCQLKS
410 420 430 440 450
LGFDKVFMYL SDSRCSGFND RDNRDWVSVV TPARDGPCGT VLTRNETHAT
460 470 480 490 500
YSNTLYLADE IIIRDLNIKI NFACSYPLDM KVSLKTALQP MVSALNIRVG
510 520 530 540 550
GTGMFTVRMA LFQNPSYTQP YQGSSVTLST EAFLYVGTML DGGDLSRFAL
560 570 580 590 600
LMTNCYATPS SNATDPLKYF IIQDRCPHAR DSTIQVVENG ESSQGRFSVQ
610 620 630 640 650
MFRFAGNYDL VYLHCEVYLC DTMNEKCKPT CSGTRFRSGS VIDQSRVLNL
660 670 680 690
GPITRKGVQA TVSRAAFSSL GLLKVWLPLL LSATLTLTFQ
Length:690
Mass (Da):75,686
Last modified:February 28, 2018 - v2
Checksum:iE094FBD7612FB9D5
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3QQY1G3QQY1_GORGO
Uromodulin
674Annotation score:
A0A2I2Y7S2A0A2I2Y7S2_GORGO
Uromodulin
681Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030099594 Genomic DNA No translation available.
CABD030099595 Genomic DNA No translation available.
CABD030099596 Genomic DNA No translation available.
RefSeqiXP_004057342.1, XM_004057294.2

Genome annotation databases

EnsembliENSGGOT00000030237; ENSGGOP00000027291; ENSGGOG00000005112
GeneIDi101145411

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030099594 Genomic DNA No translation available.
CABD030099595 Genomic DNA No translation available.
CABD030099596 Genomic DNA No translation available.
RefSeqiXP_004057342.1, XM_004057294.2

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGGOT00000030237; ENSGGOP00000027291; ENSGGOG00000005112
GeneIDi101145411

Organism-specific databases

CTDi7369

Phylogenomic databases

GeneTreeiENSGT00530000063244

Gene expression databases

BgeeiENSGGOG00000005112 Expressed in 3 organ(s), highest expression level in adult mammalian kidney

Family and domain databases

InterProiView protein in InterPro
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR024731 EGF_dom
IPR009030 Growth_fac_rcpt_cys_sf
IPR001507 ZP_dom
IPR017977 ZP_dom_CS
PfamiView protein in Pfam
PF12947 EGF_3, 1 hit
PF07645 EGF_CA, 2 hits
PF00100 Zona_pellucida, 1 hit
PRINTSiPR00023 ZPELLUCIDA
SMARTiView protein in SMART
SM00181 EGF, 3 hits
SM00179 EGF_CA, 2 hits
SM00241 ZP, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS01186 EGF_2, 2 hits
PS50026 EGF_3, 3 hits
PS01187 EGF_CA, 1 hit
PS00682 ZP_1, 1 hit
PS51034 ZP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3SGQ4_GORGO
AccessioniPrimary (citable) accession number: G3SGQ4
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: October 10, 2018
This is version 45 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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