UniProtKB - G3SGJ0 (G3SGJ0_GORGO)
Protein
Submitted name:
BRCA2 DNA repair associated
Gene
BRCA2
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Functioni
GO - Molecular functioni
- gamma-tubulin binding Source: Ensembl
- H3 histone acetyltransferase activity Source: Ensembl
- H4 histone acetyltransferase activity Source: Ensembl
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
- single-stranded DNA binding Source: Ensembl
GO - Biological processi
- brain development Source: Ensembl
- cell aging Source: Ensembl
- centrosome duplication Source: Ensembl
- DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator Source: Ensembl
- double-strand break repair via homologous recombination Source: GO_Central
- establishment of protein localization to telomere Source: Ensembl
- female gonad development Source: Ensembl
- hemopoiesis Source: Ensembl
- inner cell mass cell proliferation Source: Ensembl
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator Source: Ensembl
- male meiosis I Source: Ensembl
- mitotic recombination-dependent replication fork processing Source: Ensembl
- negative regulation of mammary gland epithelial cell proliferation Source: Ensembl
- nucleotide-excision repair Source: Ensembl
- oocyte maturation Source: Ensembl
- positive regulation of mitotic cell cycle Source: Ensembl
- positive regulation of transcription, DNA-templated Source: Ensembl
- regulation of cytokinesis Source: Ensembl
- regulation of transcription, DNA-templated Source: GO_Central
- replication fork protection Source: Ensembl
- response to gamma radiation Source: Ensembl
- response to UV-C Source: Ensembl
- response to X-ray Source: Ensembl
- spermatogenesis Source: Ensembl
- telomere maintenance via recombination Source: Ensembl
Keywordsi
Molecular function | DNA-bindingARBA annotation |
Biological process | DNA damage, DNA recombinationARBA annotation, DNA repairARBA annotation |
Names & Taxonomyi
Protein namesi | Submitted name: BRCA2 DNA repair associatedImported |
Gene namesi | Name:BRCA2Imported |
Organismi | Gorilla gorilla gorilla (Western lowland gorilla)Imported |
Taxonomic identifieri | 9595 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla › |
Proteomesi |
|
Subcellular locationi
Cytoskeleton
- centrosome Source: Ensembl
Cytosol
- cytosol Source: Ensembl
Nucleus
- lateral element Source: Ensembl
- nuclear chromosome, telomeric region Source: Ensembl
- nucleoplasm Source: Ensembl
- nucleus Source: GO_Central
Other locations
- BRCA2-MAGE-D1 complex Source: Ensembl
- secretory granule Source: Ensembl
Expressioni
Gene expression databases
Bgeei | ENSGGOG00000015808, Expressed in testis and 1 other tissue |
Interactioni
GO - Molecular functioni
- gamma-tubulin binding Source: Ensembl
- identical protein binding Source: Ensembl
- protease binding Source: Ensembl
- protein C-terminus binding Source: Ensembl
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 2830 – 2871 | TowerInterPro annotationAdd BLAST | 42 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 37 – 68 | DisorderedSequence analysisAdd BLAST | 32 | |
Regioni | 357 – 381 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 2429 – 2449 | DisorderedSequence analysisAdd BLAST | 21 | |
Regioni | 3392 – 3416 | DisorderedSequence analysisAdd BLAST | 25 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 2854 – 2878 | Sequence analysisAdd BLAST | 25 | |
Coiled coili | 3158 – 3178 | Sequence analysisAdd BLAST | 21 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 362 – 378 | PolarSequence analysisAdd BLAST | 17 | |
Compositional biasi | 3396 – 3416 | PolyampholyteSequence analysisAdd BLAST | 21 |
Keywords - Domaini
Coiled coilSequence analysis, RepeatARBA annotationPhylogenomic databases
GeneTreei | ENSGT00390000003602 |
HOGENOMi | CLU_000344_0_0_1 |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit cd04495, BRCA2DBD_OB3, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR002093, BRCA2_repeat IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 1 hit |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF00634, BRCA2, 7 hits PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
PROSITEi | View protein in PROSITE PS50138, BRCA2_REPEAT, 8 hits |
i Sequence
Sequence statusi: Complete.
G3SGJ0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPIGSKERPT FFEIFKTRCN KADLGPISLN WFEELSSEAP PYNSEPAEES
60 70 80 90 100
EHKNNNYEPN LFKTPQRKPS YNQLASTPII FKEQGLTLPL YQSPVKELDK
110 120 130 140 150
FKLDLGRNVP NSRHKSLRTV KTKMDQADDV SCPLLNSCLS ESPVVLQCTH
160 170 180 190 200
VTPQRDKSVV CGSLFHTPKF VKGRQTPKHI SESLGAEVDP DMSWSSSLAT
210 220 230 240 250
PPTLSSTVLI VRNEEASETV FPHDTTANVK SYFSNHDESL KKNDRFIASV
260 270 280 290 300
TDSENTNQRE ATSHGFGKTS GNSFKVNSCK DHIGKSMPNV LEDEVYETVV
310 320 330 340 350
DTSEEDSFSL CFSKCRTKNL QKVRTSKTRK KISHEANADE CEKSKNQVKE
360 370 380 390 400
KYSFVSEVEP NDTDPLDSNV ANQKPFESGS DKISKEVVPS LACEWSQLTL
410 420 430 440 450
SGLNGAQMEK IPLLNISSCD QNISEKDLLD TENKRKKDFL TSENSLPRIS
460 470 480 490 500
SLPKSEKPLN EETVVNKRDE EQHLESHTDC ILAVKQAISG TSPVASSFQG
510 520 530 540 550
IKKSIFRIRE SPKETFGASF SGHMTDPNFK KETEASESGL EIHTVCSQKE
560 570 580 590 600
DSLCPNLIDN GSWPATTTQT SVALKNAGLI STLKKKTNKF IYAIHDETSY
610 620 630 640 650
KGKKIPKDQK SELINCSAQF EANAFEAPLT FANADSGLLH SSVKRSCSQN
660 670 680 690 700
DSEEPTLSLT SSFGTILRKC SRNETCSNDT VISQDLDYKE AKCNKEKLQL
710 720 730 740 750
FITPEADSLS CLQEGQCEND PKSKKVSDIK EEVLAAACHP VQHSKVEYSD
760 770 780 790 800
TDFQSQKSLL YDHENASTLI LTPTSKDVLS NLVMISRGKE SYKMSDKLKG
810 820 830 840 850
NNYESDVELT KNIPMEKNQD VCALNENYKN VELLPPEKYM RVASPSRKVQ
860 870 880 890 900
FNQNTNLRVI QKNQEETTSI SKITVNPDSE ELFSDNENNF VFQVANERNN
910 920 930 940 950
LALGNTKELH ETDLTCVNEP IFKNPTMVLY GDTGDKQATQ VSIKKDLVYV
960 970 980 990 1000
LAEENKNSVK QHIKMTLGQD LKSDISLNID KIPDKNNDYM DKWAGLLGPI
1010 1020 1030 1040 1050
SNHSFGGSFR TASNKEIKLS EHNIKKSKMF FKDIEEQYPT SLACVEIVNT
1060 1070 1080 1090 1100
LALDNQKKLS KPQSINTVSA HLQSSVVVSD CKNSHITPQM LFSKQDFNSN
1110 1120 1130 1140 1150
HNLTPSQKAE ITELSTILEE SGSQFEFTQF RKPSYILQKS TFEVPENQMT
1160 1170 1180 1190 1200
ILKTTSEECR DADLHVIMNA PSIGQLDSSK QFEGTVEIKR KFAGLLKNDC
1210 1220 1230 1240 1250
NKSASGYLTD ENEVGFRGFY SAHGAKLNVS TEALQKAVKL FSDIENISEE
1260 1270 1280 1290 1300
TSAEVHPISL SSSKCHDSVV SMFKIENHND KTVSEKNKCQ LILQNNIEMT
1310 1320 1330 1340 1350
TGTFVEEITE NYKRNTENED NKYTAASRNS HNLEFDGSDS SKNDTVCIHK
1360 1370 1380 1390 1400
DETDLLFTDQ HNICLKLSGQ FMKEGNTQIK EDLSDLTFLE VVKAQEACHG
1410 1420 1430 1440 1450
NTSNKEQLTA TKTEQNIKDF ETSDTFFQTA SGKNISVAKE SFNKIVNFFD
1460 1470 1480 1490 1500
QKPEELHNFS LNSELHSDIR KNKMDILSYE ETDIVKHKIL KESVPVGTGN
1510 1520 1530 1540 1550
QLVTFQGQPE RDEKIKEPTL LGFHTASGKK VKIAKESLDK VKNLFDEKEQ
1560 1570 1580 1590 1600
GTSEITSFSH QWAKTLKYRE ACKDLELACE TIEITTAPKC KEMQNSLNND
1610 1620 1630 1640 1650
KNLVSIETVV PPKLLSDNLC RQTENLKTSK SIFLKVKVHE NVEKETAKSP
1660 1670 1680 1690 1700
ATCYTNQSPY SVIENSALAF YTSCSRKTSV SQTSLREAKK WLREGIFDGQ
1710 1720 1730 1740 1750
PERINTADYV GNYLYENNSN STIAENDKNH LSEKQDTYLS NSSMSNSYSY
1760 1770 1780 1790 1800
HSDEVYNDSG YLSKNKLDSG IEPVLKNVED QKNTSFSKVI SNVKDANAYP
1810 1820 1830 1840 1850
QTVNEDICVE ELVTSSSPCK NKNAAIKLSI SNSNNFEVGP PAFRIASGKI
1860 1870 1880 1890 1900
VCVSHETIKK VKDMFTDSFS KVIKENNENK SKICQTKIMA GCYEALDDSE
1910 1920 1930 1940 1950
DILHNSLDND ECSTHSHKVF ADIQSEEILQ HNQNMSGLEK VSKISPCDVS
1960 1970 1980 1990 2000
LETSDICKCS IGKLHKSVSS TNTCGIFSTA SGKSVQVSDA SLQNARQVFS
2010 2020 2030 2040 2050
EIEDSTKQVF SKVLFKSNEH SDQLTREENT AIRTPEHLIS QKGFSYNVVN
2060 2070 2080 2090 2100
SSAFSGFSTA SGKQVSILES SLHKVKGVLE EFDLIRTEHS LHYSPTSRQN
2110 2120 2130 2140 2150
VSKILPRVDK RNPEHCVNSE MEKTCSKEFK LSNNLNVEGG SSENNHSIKV
2160 2170 2180 2190 2200
SPYLSQFQQD KQQLVLGTKV SLVENIHVLG KEQASPENVK MEIGKTEAFS
2210 2220 2230 2240 2250
DVPVKTNIEV CSTYSKDSEN YFETEAVEIA KAFMEDDELT DSELPSHATH
2260 2270 2280 2290 2300
SLFTCPENEE MVLSNSRTGK RRGEPLILVG EPSIKRNLLN EFDRIIENQE
2310 2320 2330 2340 2350
KSLKASKSTP DGTIKDRRLF MHHVSLEPIT CVPFRTTKEH QEIQNPNFTA
2360 2370 2380 2390 2400
PGQEFLSESH LYEHLTLEKS SSNLAVSGHP FYQVSATRNE KMRHLITTGR
2410 2420 2430 2440 2450
PTKVFVPPFK TKSHFHRVEQ CVRNINLEEN RQKQNIDGHG SDDSKNKIND
2460 2470 2480 2490 2500
NEIHQFNKNN SNQAAAVTFT KCEEEPLDLI TSLQNARDIQ DMRIKKKQRQ
2510 2520 2530 2540 2550
RVFPQPGSLY LAKTSTLPRI SLKAAVGGQV PSACSHKQLY TYGVSKHCIK
2560 2570 2580 2590 2600
INSKNAESFQ FHTEDYFGKE SLWTGKGIQL ADGGWLIPSS DGKAGKEEFY
2610 2620 2630 2640 2650
RALCDTPGVD PKLISRIWVY NHYRWIIWKL AAMECAFPKE FANRCLSPER
2660 2670 2680 2690 2700
VLLQLKYRYD MEIDRSRRSA IKKIMERDDT AAKTLVLCVS DIISLSANIS
2710 2720 2730 2740 2750
ETSSNKTSSA DTQKVAIIEL TDGWYAVKAQ LDPPLLAVLK NGRLTVGQKI
2760 2770 2780 2790 2800
ILHGAELVGS PDACTPLEAP ESLMLKISAN STRPARWYTK LGFFPDPRPF
2810 2820 2830 2840 2850
PLPLSSLFSD GGNVGCVDVI IQRAYPIQWM EKTSSGLYIF RNEREEEKEA
2860 2870 2880 2890 2900
AKYVEAQQKR LEALFTKIQE EFEEHEENTT KPYLPSRALT RQQVRALQDG
2910 2920 2930 2940 2950
AELYEAVKNA ADPANLEGYF SEEQLRALNN HRQMLNDKKQ AQIQLEVRKA
2960 2970 2980 2990 3000
MESAEQKEKG LSRDVTTVWK LRIVSYSKKE KDSVILSIWR PSSDLYSLLT
3010 3020 3030 3040 3050
EGKRYRIYHL ATSKSKSKSE RANIQLAATK KTQYQQLPVS DEILFQVYQP
3060 3070 3080 3090 3100
REPLHFSKFL DPDFQPSCSE VDLIGFVISV VKKTGLAPFV YLSDECYNLL
3110 3120 3130 3140 3150
AIKFWIDLNE DIIKPHMLIA ASNLQWRPES KSGLPTLFAG DFSVFSASPK
3160 3170 3180 3190 3200
EGHFQETFNK MKNTVENIDI LCNEAENKLM HILHANDPKW STPTKDCTSG
3210 3220 3230 3240 3250
PYTAQIIPGT GNKLLMSSPN CEIYYQSPLS LCMAKRKSVS TPVSAQMTSK
3260 3270 3280 3290 3300
SCKGEKEIDD QKNCKKRRAL DFLSRLPLPP PVSPICTFVS PAAQKAFQPP
3310 3320 3330 3340 3350
RSCGTKYETP IKKKELNSPQ MTPFKKFNEI SLLESNSIAD EELALINTQA
3360 3370 3380 3390 3400
LLSGSTGEKQ FISVSESTRT APTSSEDYLR LKRRCTSLIK EQESSQASTE
3410
ECEKNKQDTI TTKKYI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030088451 Genomic DNA No translation available. CABD030088452 Genomic DNA No translation available. |
Genome annotation databases
Ensembli | ENSGGOT00000011464; ENSGGOP00000027226; ENSGGOG00000015808 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030088451 Genomic DNA No translation available. CABD030088452 Genomic DNA No translation available. |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSGGOT00000011464; ENSGGOP00000027226; ENSGGOG00000015808 |
Phylogenomic databases
GeneTreei | ENSGT00390000003602 |
HOGENOMi | CLU_000344_0_0_1 |
Gene expression databases
Bgeei | ENSGGOG00000015808, Expressed in testis and 1 other tissue |
Family and domain databases
CDDi | cd04493, BRCA2DBD_OB1, 1 hit cd04495, BRCA2DBD_OB3, 1 hit |
InterProi | View protein in InterPro IPR015525, BRCA2 IPR015252, BRCA2_hlx IPR036315, BRCA2_hlx_sf IPR015187, BRCA2_OB_1 IPR015188, BRCA2_OB_3 IPR002093, BRCA2_repeat IPR012340, NA-bd_OB-fold IPR015205, Tower_dom |
PANTHERi | PTHR11289, PTHR11289, 1 hit |
Pfami | View protein in Pfam PF09169, BRCA-2_helical, 1 hit PF09103, BRCA-2_OB1, 1 hit PF09104, BRCA-2_OB3, 1 hit PF00634, BRCA2, 7 hits PF09121, Tower, 1 hit |
PIRSFi | PIRSF002397, BRCA2, 1 hit |
SMARTi | View protein in SMART SM01341, Tower, 1 hit |
SUPFAMi | SSF50249, SSF50249, 3 hits SSF81872, SSF81872, 1 hit |
PROSITEi | View protein in PROSITE PS50138, BRCA2_REPEAT, 8 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3SGJ0_GORGO | |
Accessioni | G3SGJ0Primary (citable) accession number: G3SGJ0 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | February 28, 2018 | |
Last modified: | February 10, 2021 | |
This is version 52 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |