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Protein
Submitted name:

G protein-coupled receptor 179

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
G protein-coupled receptor 179Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei382 – 403HelicalSequence analysisAdd BLAST22
Transmembranei415 – 438HelicalSequence analysisAdd BLAST24
Transmembranei450 – 469HelicalSequence analysisAdd BLAST20
Transmembranei490 – 513HelicalSequence analysisAdd BLAST24
Transmembranei544 – 564HelicalSequence analysisAdd BLAST21
Transmembranei606 – 628HelicalSequence analysisAdd BLAST23

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25Sequence analysisAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_501414375826 – 2367Sequence analysisAdd BLAST2342

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000010947 Expressed in 2 organ(s), highest expression level in cerebellum

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000024835

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini380 – 650G_PROTEIN_RECEP_F3_4InterPro annotationAdd BLAST271

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili865 – 885Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160776

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3S9R7

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0GG1

TreeFam database of animal gene trees

More...
TreeFami
TF319114

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR017978 GPCR_3_C
IPR032964 GPR179

The PANTHER Classification System

More...
PANTHERi
PTHR32546:SF7 PTHR32546:SF7, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00003 7tm_3, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3S9R7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGTRGAVMLP PMWGLLGCCF VCGWALGGPR PIRSLPPLSS QVKPGSVPMQ
60 70 80 90 100
VPLEGAEAAL AYLYSGDAQQ LSQVNCSERY EARGAGAMPG LPPSLQGAAG
110 120 130 140 150
TLAQAANFLN MLLQANDIRE SSVEEDVEWY QALVRSVAEG DPRVYRALLT
160 170 180 190 200
FNPPPGASHL QLALQATRTG EETILQDLSG NWVQEENPPG DLDTPALKKR
210 220 230 240 250
VLTNDLGSLG SPKWPQADGY VGDTQQVRLS PPFLECQEGR LRPGWLITLS
260 270 280 290 300
ATFYGLKPDL SPEVRGQVQM DVDLQSVDIN QCASGPGWYS NTHLCDLNST
310 320 330 340 350
QCVPLESQGF VLGRYLCRCR PGFYGASPSG GLEESDFQTT GQFGFPEGRS
360 370 380 390 400
GRLLQCLPCP EGCTSCMDAT PCLVEEAAAL RAAVLACQAC CMLAIFLSML
410 420 430 440 450
VSYRCRQNKR IWASGVVLLE TVLFGFLLLY FPVFIVYFKP SVFRCIALRW
460 470 480 490 500
VRLLGFAIVY GTIILKLYRV LQLFLSRTAQ RSALLSSGRL LRRLGLLLLP
510 520 530 540 550
VLGFLAVWTV GALERGIQHA PLVIRGHTPS GRHFYLCHHD RWDYIMVVAE
560 570 580 590 600
LLLLCWGSFL CYATRAVLSA FHEPRYMGIA LHNELLLSAA FHTARFVLVP
610 620 630 640 650
SLHPDWTLLL FFFHTHSTAT TTLALIFIPK FWKLGAPPRE EMVDEVCEDE
660 670 680 690 700
LDLQHSGSYL GSSIASAWSE HSLDPGDIRD ELKKLYAQLE VHKTKEMAAN
710 720 730 740 750
NPHLPKKRGS SCQGLGRSFM RYLAEFPEAL ARQHSRDSGS PGHGSLPGSS
760 770 780 790 800
RRRLLSSSLQ EPEGTPALRK SRSTYDQRRE QDPPLLDSLL RRKLAKKASR
810 820 830 840 850
TDSRESVEGP PALGFRSASA HNLTVGERLP RTRPASLQKS LSVAGSREKA
860 870 880 890 900
LLMASQAYLE ETYRQAKERE ERKKAKAAMA SLARRPSARR LERPQGAPLS
910 920 930 940 950
APPSPAKSSS MDSSHTSGRL HEEAGRRLPH PPIRHQVSTP ILALSGGLGE
960 970 980 990 1000
PRMLSPTSTL APALLPALAP TPAPALAPVP VSPQSPNLLT YICPWENAEL
1010 1020 1030 1040 1050
PAKQENVPQE GPSGPERGHH SPAPARARLW RALSVAVEKS RAGENEMDAE
1060 1070 1080 1090 1100
DAHHQREAND VDEDRPKIFP KSHSLKAPVQ QGSMCSLGLA IKALTRSRST
1110 1120 1130 1140 1150
YREKESVEES PEGQNSGTAG ESMGAPSRSP RLGRPKAVSK QAALIPSDDE
1160 1170 1180 1190 1200
ESLQNQQNAH TSRMLQVCQR EGSREQEDRG RRMIQGLGER KAERAGKTGL
1210 1220 1230 1240 1250
AVLRQVSRDK NIEQSKETPV GWQELPKAGL QSLGSADHRV AEVCPWEVTE
1260 1270 1280 1290 1300
SETRQPDSGN KAEICPWETS EGAPESRALR QDPGDSQKKR GEARGKSEPI
1310 1320 1330 1340 1350
DVVPMMRKKP ERLVREQEAV CPWESADRGG LSPGSAPQDP GRIRDKSEAG
1360 1370 1380 1390 1400
DSVEARKVEK PGWEAAGPEA HTPDITKAEP CPWEASEGGE DGKPAQEAVK
1410 1420 1430 1440 1450
DLPQEKQKTR KATFWKEQKP GGDLESLCPW ESTDFRGPSA VSIQAPGSSK
1460 1470 1480 1490 1500
YSGSLGSGIA EVCLWEAGDA PAIQKAEICP WELDDNVMGQ EMLSLGTGRE
1510 1520 1530 1540 1550
SLQEKEKASR KGSFGEMGEQ TVKAVQKLSQ QQESVCPRES TVPGHSSPCL
1560 1570 1580 1590 1600
DNSSSKAGSQ FLCNGGSRAT QVCPQEDLRP EAQEATPAKT EICPWEVNER
1610 1620 1630 1640 1650
TREEWTSAQV PRGGESQKDK EKMPGKSEIE DVTAWEKPEG QIQKQEAVGP
1660 1670 1680 1690 1700
WESVDPGSFS PQPRPQDTER PQTLLQMSGS VGSKAADICP LDMEENLTAR
1710 1720 1730 1740 1750
KAEICPWEVG AGAGEERALG AEATRKSPND TGKVSADLGP RERAVTAPEK
1760 1770 1780 1790 1800
PQKPTPEWEV ACPWGSVGPG ACSQHPGTLD ADGPKAGFQE LDHMGCRPGE
1810 1820 1830 1840 1850
VCPWEAQEAA TSEKAKICPW EVNEGTTGKG LDQKAGSESA EQREKALEKG
1860 1870 1880 1890 1900
RLTSLGEDVS KGMAKLCQEQ ETICIWENKD LRESPAQAPK ISDLPSSMSS
1910 1920 1930 1940 1950
EVAEGHSLEA TEKGDLRQDP KTGSFPEHIT QEKAPAADTE EFTTEDGEKT
1960 1970 1980 1990 2000
SHELQSVCPW ETTAPAGSVS HLDRQRPDQP KGSSQRLVST GGRAADVCPW
2010 2020 2030 2040 2050
DVPDAGVYKS DSSAKAETCP WEVTERIPVK GVSRQDGKGD SQEEKGRAPE
2060 2070 2080 2090 2100
KSEPKGVPVQ KKPEMADFRQ QEAVCPWESQ DGKGLSPQPA PDASDRIRGS
2110 2120 2130 2140 2150
SEAAGSVETR VAEVCLWEVL EAPSAKKAEI CPWEAGGGAA EEGEQERESQ
2160 2170 2180 2190 2200
GQGEMFLQKA GPGETEEHFS KAAAKPREQE AVCPGEGTGS GGLLPQSGAL
2210 2220 2230 2240 2250
DPELKVSPKE AGSMGSRMAE LCQWEITDPE GNKIKGTMAD ICPGEETGVS
2260 2270 2280 2290 2300
SEESGLLALT ATRREFFPTA PEKPLCLLVH GPLDHFFPES KIPCPKVSRP
2310 2320 2330 2340 2350
ASTFTLEGVR ELQGPSGLEP RTSLAPEPSI QEAESQSSSL TEDSGQVAFE
2360
AQYEEFTPPT VYPWDWE
Length:2,367
Mass (Da):257,314
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA374AEDD3DB945A0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030038094 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_004041879.2, XM_004041831.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000029520; ENSGGOP00000024835; ENSGGOG00000010947

Database of genes from NCBI RefSeq genomes

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GeneIDi
101146041

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ggo:101146041

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030038094 Genomic DNA No translation available.
RefSeqiXP_004041879.2, XM_004041831.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000024835

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGGOT00000029520; ENSGGOP00000024835; ENSGGOG00000010947
GeneIDi101146041
KEGGiggo:101146041

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
440435

Phylogenomic databases

GeneTreeiENSGT00940000160776
InParanoidiG3S9R7
OrthoDBiEOG091G0GG1
TreeFamiTF319114

Gene expression databases

BgeeiENSGGOG00000010947 Expressed in 2 organ(s), highest expression level in cerebellum

Family and domain databases

InterProiView protein in InterPro
IPR017978 GPCR_3_C
IPR032964 GPR179
PANTHERiPTHR32546:SF7 PTHR32546:SF7, 1 hit
PfamiView protein in Pfam
PF00003 7tm_3, 1 hit
PROSITEiView protein in PROSITE
PS50259 G_PROTEIN_RECEP_F3_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3S9R7_GORGO
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3S9R7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: December 5, 2018
This is version 47 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
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