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UniProtKB - G3S077 (TOPZ1_GORGO)

Entry version 37 (02 Dec 2020)
Sequence version 1 (16 Nov 2011)
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Protein

Protein TOPAZ1

Gene

TOPAZ1

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein TOPAZ1By similarity
Alternative name(s):
Testis- and ovary-specific PAZ domain-containing protein 1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TOPAZ1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004160581 – 1694Protein TOPAZ1Add BLAST1694

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSGGOG00000025876, Expressed in testis and 1 other tissue

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9593.ENSGGOP00000021471

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502QPIV, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_003190_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		G3S077

Identification of Orthologs from Complete Genome Data

More...OMAi		NIFMEYY

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom

The PANTHER Classification System

More...PANTHERi		PTHR35671, PTHR35671, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3S077-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRPPPLGPT TASGPEGNVR NLQKRQAPGP GAAGGCGPEA GGRRENKQKR 
        60         70         80         90        100
RMVARATPGR GEVESDKSVA ASGAGKAARR RVEGRRGQVS PSDSSDPRGL 
       110        120        130        140        150
EAAKEAELPL QTERHTKEKR KVTEASSDDP QPGLDLVRKE SLTSSESFQT 
       160        170        180        190        200
VECLQSLGKE SIIEGIKRRI RNKKLKSLEN PPLKITENEA TQNIKVEFQD 
       210        220        230        240        250
ELYKNTPKYS CNILSPEVEN NSVLKLRDCN CFPHSKGCND ENNLPYKPDG 
       260        270        280        290        300
GCMHVAENFS KKENLRSLAE KSDTNSIPQL LQTEENVMEV NKLLPEESDL 
       310        320        330        340        350
YQSKTNGLLS CLQHEKNKYS IEESSVGRKP RKRMKLSEKA DETVTEMNFS 
       360        370        380        390        400
NEYNKSELML QENQMIADGK EAETKSPLNV LRKVSHNTVS LMDHLLSVPE 
       410        420        430        440        450
TVEKETSSEH HVNAVFQKTI EPLLKEETES TSEPLGYESM ASKEDFKSMK 
       460        470        480        490        500
SFIGKSPNEY HIERRSSRED LRSASEELNL SCQRTIPMTG KRTWPCYSCA 
       510        520        530        540        550
RISAWCWKKA SLPESSYFFP GSQESYRQVD VPKHQTNQTH LTDSKLLLQS 
       560        570        580        590        600
SLTETNTESS SKEKLDSNSN CLSSVSAVEP TLMVIKEPII KDDKKIKSEE 
       610        620        630        640        650
LSRSGSEVIS NTTEDTQLTS ETQSLTGNKK KARGNLMKLN LTATSKDGQE 
       660        670        680        690        700
ANNSAGKTIH RKACIAQQTF IVPDLVKILN TGRLTNFKIP LLKNKTEKRK 
       710        720        730        740        750
EVNAKSSERE AYSPLELLDN LSGADIRQNR SKENVSMTML GPQTLSIRNS 
       760        770        780        790        800
VTPVQASSDS FYNKKSYSIS PSFTKQGNNS KPSNHVSEPG NIVSNKEVAS 
       810        820        830        840        850
LTVENNAFSC DPGYVEKSPS FCCNEQETFR PVSSEVRGRK ITKNFSEVGF 
       860        870        880        890        900
PDILKAYEDD ILLIDVIQDD PDLFGVSNEG ELSFTSEVPK ISQEEPNVAG 
       910        920        930        940        950
EHQSTDSKYM ETPVKKEPSD DLRELPVLDC GWIKPDICAS NSAESEIKHD 
       960        970        980        990       1000
PKDVNTSLGE VANETSENET LGDFSEQIKG SDLDEKHRFT DKVITKEEKE 
      1010       1020       1030       1040       1050
NIYEVCKSKD SRNADIMVGE CQFAVPVPKP LCLLVPPLNL SGRQEDTILN 
      1060       1070       1080       1090       1100
TWMNGTICFL NEILLAFGNI ETRRFFYQKQ KTIKVFQKSL GLMIPYKYCK 
      1110       1120       1130       1140       1150
FHFNTLRGCE RPLCKFAHVP EQGDEKVCMD VFKKYININE LCLLQRAVNI 
      1160       1170       1180       1190       1200
FMEYYRKFPP GVYFDLQVLN DLLNSLLKHC LLKEVFQIVN LSIMVKMLPS 
      1210       1220       1230       1240       1250
LKILLNIFEY VATMKLRNAV PALIDIFCKL VEAGMVLDPE HFNYIVKLLY 
      1260       1270       1280       1290       1300
QVQASKQEIT AVLEMKSRLQ MRQFKKNWKC DLHSALNKLE HCKEKGDWTK 
      1310       1320       1330       1340       1350
LGKLYINVKM GCEKFADFQT FCACIAETLT KNYEDERPDI PFCEFAETVS 
      1360       1370       1380       1390       1400
KDPQNSKVDK GVLGRIGISA MCFYHKLLQW SKGRKVLEKL YELKIHFTSL 
      1410       1420       1430       1440       1450
KGLIGPEKLA SRCQIVNVAA EIFLKSGSLD GAIWVMRESE WIINTPLWPC 
      1460       1470       1480       1490       1500
DRLDVLNRHN LLCTIAHEIL AKSLYRQTFE VLQNLPGFQN SQETVEVSQY 
      1510       1520       1530       1540       1550
SLLFNKLLGS CIESSSLGMS SSVAEFMISK SIPIDFSFLR RLITSLGRSC 
      1560       1570       1580       1590       1600
LWLKARAHYK SALSLGCYPP LEGNLYRKLL LIPSYLSEIE MLLAIEIFMV 
      1610       1620       1630       1640       1650
SNASSIQSPG TSTQILQIVL KRCEDNQSRS SDDYQAAVER LIMAARISDP 
      1660       1670       1680       1690 
KLFVKHMTVN VNKEQVYSLE HCSALKWLKE NMKWAGKVWL FSNH
Length:1,694
Mass (Da):191,137
Last modified:November 16, 2011 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i600C368029599629
GO

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000021471

Phylogenomic databases

eggNOGiENOG502QPIV, Eukaryota
HOGENOMiCLU_003190_0_0_1
InParanoidiG3S077
OMAiNIFMEYY

Gene expression databases

BgeeiENSGGOG00000025876, Expressed in testis and 1 other tissue

Family and domain databases

InterProiView protein in InterPro
IPR038952, TOPAZ1
IPR029435, TOPAZ1_dom
PANTHERiPTHR35671, PTHR35671, 1 hit
PfamiView protein in Pfam
PF14669, Asp_Glu_race_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTOPZ1_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3S077
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2012
Last sequence update: November 16, 2011
Last modified: December 2, 2020
This is version 37 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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