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Entry version 44 (26 Feb 2020)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

Signal induced proliferation associated 1 like 1

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activationPROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Signal induced proliferation associated 1 like 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000013648 Expressed in prefrontal cortex and 5 other tissues

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 157DisorderedSequence analysisAdd BLAST157
Regioni277 – 297DisorderedSequence analysisAdd BLAST21
Regioni380 – 401DisorderedSequence analysisAdd BLAST22
Regioni1067 – 1128DisorderedSequence analysisAdd BLAST62
Regioni1144 – 1210DisorderedSequence analysisAdd BLAST67
Regioni1247 – 1285DisorderedSequence analysisAdd BLAST39
Regioni1306 – 1343DisorderedSequence analysisAdd BLAST38
Regioni1358 – 1454DisorderedSequence analysisAdd BLAST97

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1719 – 1767Sequence analysisAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 95PolyampholyteSequence analysisAdd BLAST16
Compositional biasi96 – 144PolarSequence analysisAdd BLAST49
Compositional biasi1067 – 1093PolarSequence analysisAdd BLAST27
Compositional biasi1144 – 1166PolarSequence analysisAdd BLAST23
Compositional biasi1182 – 1210PolarSequence analysisAdd BLAST29
Compositional biasi1249 – 1278PolarSequence analysisAdd BLAST30
Compositional biasi1306 – 1328PolarSequence analysisAdd BLAST23
Compositional biasi1358 – 1372PolyampholyteSequence analysisAdd BLAST15
Compositional biasi1373 – 1419PolarSequence analysisAdd BLAST47
Compositional biasi1434 – 1454PolarSequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155944

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002127_0_1_1

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.11210, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR030770 SIPA1L1
IPR021818 SIPA1L_C

The PANTHER Classification System

More...
PANTHERi
PTHR15711:SF10 PTHR15711:SF10, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00228 PDZ, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3RXQ6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTSLKRSQTE RPLATDRASV VGTDSTPKVH TDDFYMRRFR SQNGSLGSSV
60 70 80 90 100
MAPVGPPRSE GSHHITSTPG VPKMGVRARI ADWPPRKENI KESSRSSQEI
110 120 130 140 150
ETSSCLDSLS SKSSPVSQGS SVSLNSNDSA MLKSIQNTLK NKTRPSENMD
160 170 180 190 200
SRFLMPEAYP SSPRKALRRI RQRSNSDITI SELDVDSFDE CISPTYKTGP
210 220 230 240 250
SLHREYGSTS SIDKQGTSGE SFFDLLKGYK DDKSDRGPTP TKLSDFLITG
260 270 280 290 300
GGKGSGFSLD VIDGPISQRE NLRLFKEREK PLKRRSKSET GDSSIFRKLR
310 320 330 340 350
NAKGEELGKS SDLEDNRSED SVRPWTCPKC FAHYDVQSIL FDLNEAIMNR
360 370 380 390 400
HNVIKRRNTT TGASAAAVAS LVSGPLSHSA SFSSPMGSTE DLNSKGSLSM
410 420 430 440 450
DQGDDKSNEL VMSCPYFRNE IGGEGERKIS LSKSNSGSFS GCESASFEST
460 470 480 490 500
LSSHCTNAGV AVLEVPKENL VLHLDRVKRY IVEHVDLGAY YYRKFFYQKE
510 520 530 540 550
HWNYFGADEN LGPVAVSIRR EKPDEMKENG SPYNYRIIFR TSELMTLRGS
560 570 580 590 600
VLEDAIPSTA KHSTARGLPL KEVLEHVVPE LNVQCLRLAF NTPKVTEQLM
610 620 630 640 650
KLDEQGLNYQ QKVGIMYCKA GQSTEEEMYN NESAGPAFEE FLQLLGERVR
660 670 680 690 700
LKGFEKYRAQ LDTKTDSTGT HSLYTTYKDY EIMFHVSTML PYTPNNKQQL
710 720 730 740 750
LRKRHIGNDI VTIVFQEPGA QPFSPKNIRS HFQHVFVIVR VHNPCSDSVC
760 770 780 790 800
YSVAVTRSRD VPSFGPPIPK GVTFPKSNVF RDFLLAKVIN AENAAHKSEK
810 820 830 840 850
FRAMATRTRQ EYLKDLAEKN VTNTPIDPSG KFPFISLASK KKEKSKPYPG
860 870 880 890 900
AELSSMGAIV WAVRAEDYNK AMELDCLLGI SNEFIVLIEQ ETKSVVFNCS
910 920 930 940 950
CRDVIGWTST DTSLKIFYER GECVSVGSFI NNEEIKEIVK RLQFVSKGCE
960 970 980 990 1000
SVEMTLRRNG LGQLGFHVNY EGIVADVEPY GYAWQAGLRQ GSRLVEICKV
1010 1020 1030 1040 1050
AVATLSHEQM IDLLRTSVTV KVVIIPPHDD CTPRRSCSET YRMPVMEYKM
1060 1070 1080 1090 1100
NEGVSYEFKF PFRNNNKWQR NASKGPHSPQ VPSQVQSPMT SRLNAGKGDG
1110 1120 1130 1140 1150
KMPPPERAAN IPRSISSDGR PLERRLSPGS DIYVTVSSMA LARSQCRNSP
1160 1170 1180 1190 1200
SNLSSSSDTG SVGGTYRQKS MPEGFGVSRR SPASIDRQNT QSDIGGSGKS
1210 1220 1230 1240 1250
TPSWQRSEDS IADQMEPTCH LPAVSKVLPA FRESPSGRLM RQDPVVHLSP
1260 1270 1280 1290 1300
NKQGHSDSHY SSHSSSNTLS SNASSAHSDE KWYDGDRTES ELNSYNYLQG
1310 1320 1330 1340 1350
TSADSGIDTT SYGPSHGSTA SLGAATSSPR SGPGKEKVAP LWHSSSEVIS
1360 1370 1380 1390 1400
MADRTLETES HGLDRKTESS LSLDIHSKSQ AGSSPLTREN STFSINDAAS
1410 1420 1430 1440 1450
HTSTMSSRHS ASPVVFTSAR SSPKEELHPA APSQLAPSFS SSSSSSSGPR
1460 1470 1480 1490 1500
SFYPRQGATS KYLIGWKKPE GTINSVGFMD TRKRHQSDGN EIAHTRLRAS
1510 1520 1530 1540 1550
TRDLRASPKP TSKSTIEEDL KKLIDLESPT PESQKSFKFH ALSSPQSPFP
1560 1570 1580 1590 1600
STPTSRRALH RTLSDESIYS SQREHFFTSR ASLLDQALPN DVLFSSTYPS
1610 1620 1630 1640 1650
LPKSLPLRRP SYTLGMKSLH GEFSASDSSL TDIQETRRQP MPDPGLMPLP
1660 1670 1680 1690 1700
DTAADLDWSN LVDAAKAYEV QRASFFAASD ENHRPLSAAS NSDQLEDQAL
1710 1720 1730 1740 1750
AQMKPYSSKD SSPTLASKVD QLEGMLKMLR EDLKKEKEDK AHLQAEVQHL
1760 1770 1780
REDNLRLQEE SQNASDKLKK FTEWVFNTID MS
Length:1,782
Mass (Da):197,398
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5E91BF39F8B0F24F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3RCU0G3RCU0_GORGO
Signal induced proliferation associ...
1,804Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2ZCR0A0A2I2ZCR0_GORGO
Signal induced proliferation associ...
1,267Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YH51A0A2I2YH51_GORGO
Signal induced proliferation associ...
651Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030093083 Genomic DNA No translation available.
CABD030093084 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_018865460.1, XM_019009915.1
XP_018865461.1, XM_019009916.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000027040; ENSGGOP00000020593; ENSGGOG00000013648

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101126496

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030093083 Genomic DNA No translation available.
CABD030093084 Genomic DNA No translation available.
RefSeqiXP_018865460.1, XM_019009915.1
XP_018865461.1, XM_019009916.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsembliENSGGOT00000027040; ENSGGOP00000020593; ENSGGOG00000013648
GeneIDi101126496

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
26037

Phylogenomic databases

GeneTreeiENSGT00940000155944
HOGENOMiCLU_002127_0_1_1

Gene expression databases

BgeeiENSGGOG00000013648 Expressed in prefrontal cortex and 5 other tissues

Family and domain databases

Gene3Di3.40.50.11210, 1 hit
InterProiView protein in InterPro
IPR001478 PDZ
IPR036034 PDZ_sf
IPR035974 Rap/Ran-GAP_sf
IPR000331 Rap_GAP_dom
IPR030770 SIPA1L1
IPR021818 SIPA1L_C
PANTHERiPTHR15711:SF10 PTHR15711:SF10, 1 hit
PfamiView protein in Pfam
PF02145 Rap_GAP, 1 hit
PF11881 SPAR_C, 1 hit
SMARTiView protein in SMART
SM00228 PDZ, 1 hit
SUPFAMiSSF111347 SSF111347, 1 hit
SSF50156 SSF50156, 1 hit
PROSITEiView protein in PROSITE
PS50106 PDZ, 1 hit
PS50085 RAPGAP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3RXQ6_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3RXQ6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: February 26, 2020
This is version 44 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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