UniProtKB - G3RPG3 (G3RPG3_GORGO)
Protein
Submitted name:
Major histocompatibility complex, class II, DQ beta 1
Gene
HLA-DQB1
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Functioni
GO - Biological processi
- adaptive immune response Source: UniProtKB-KW
- antigen processing and presentation of peptide antigen via MHC class I Source: UniProtKB-KW
- antigen processing and presentation of peptide or polysaccharide antigen via MHC class II Source: UniProtKB-KW
Keywordsi
Biological process | Adaptive immunity, Immunity |
Names & Taxonomyi
Protein namesi | Submitted name: Major histocompatibility complex, class II, DQ beta 1Imported |
Gene namesi | Name:HLA-DQB1Imported |
Organismi | Gorilla gorilla gorilla (Western lowland gorilla)Imported |
Taxonomic identifieri | 9595 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla › |
Proteomesi |
|
Subcellular locationi
Endosome
- Endosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Lysosome
- Lysosome membrane ARBA annotation; Single-pass type I membrane protein ARBA annotation
Endosome
- endosome membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB-SubCell
Plasma Membrane
- MHC class I protein complex Source: UniProtKB-KW
- MHC class II protein complex Source: UniProtKB-KW
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 231 – 251 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
EndosomeARBA annotation, LysosomeARBA annotation, Membrane, MHC IIARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 30 | Sequence analysisAdd BLAST | 30 | |
ChainiPRO_5003452955 | 31 – 261 | Sequence analysisAdd BLAST | 231 |
Keywords - PTMi
GlycoproteinARBA annotationExpressioni
Gene expression databases
Bgeei | ENSGGOG00000004252, Expressed in liver and 7 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 129 – 217 | Ig-likeInterPro annotationAdd BLAST | 89 |
Sequence similaritiesi
Belongs to the MHC class I family.ARBA annotation
Keywords - Domaini
SignalSequence analysisARBA annotation, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
GeneTreei | ENSGT00940000154723 |
HOGENOMi | CLU_047501_13_1_1 |
OrthoDBi | 1186163at2759 |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
G3RPG3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSWKKALQIP GDLRVATVTL MLAMLSSLLA EGRDSPEDFV VQFKAMCYFT
60 70 80 90 100
NGTERVRYVT RYIYNREESA RFDSDVGVYR AVTPQGRPDA EYWNSHKDIL
110 120 130 140 150
ESTRAELDTV CRNNYEVAFR GILQRRVEPT VTISPSRTEA LNHHNLLVCS
160 170 180 190 200
VTDFYPGQIK VRWFRNDQEE TAGVVSTPLI RNGDWTFQIL VMLEMTPQRG
210 220 230 240 250
DVYTCHVEHP SLQSPITVEW RAQSESAQSK MLSGVGGFVL GLIFLGLGLI
260
IRQRSQKGLL H
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG3QNQ2 | G3QNQ2_GORGO | Major histocompatibility complex, c... | HLA-DQB1 | 224 | Annotation score: | ||
G3QEJ2 | G3QEJ2_GORGO | Major histocompatibility complex, c... | HLA-DQB1 | 158 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030044295 Genomic DNA No translation available. |
RefSeqi | XP_004043821.1, XM_004043773.2 |
Genome annotation databases
Ensembli | ENSGGOT00000033362; ENSGGOP00000017683; ENSGGOG00000004252 |
GeneIDi | 101133052 |
KEGGi | ggo:101133052 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030044295 Genomic DNA No translation available. |
RefSeqi | XP_004043821.1, XM_004043773.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
Ensembli | ENSGGOT00000033362; ENSGGOP00000017683; ENSGGOG00000004252 |
GeneIDi | 101133052 |
KEGGi | ggo:101133052 |
Phylogenomic databases
GeneTreei | ENSGT00940000154723 |
HOGENOMi | CLU_047501_13_1_1 |
OrthoDBi | 1186163at2759 |
Gene expression databases
Bgeei | ENSGGOG00000004252, Expressed in liver and 7 other tissues |
Family and domain databases
Gene3Di | 2.60.40.10, 1 hit 3.10.320.10, 1 hit |
InterProi | View protein in InterPro IPR007110, Ig-like_dom IPR036179, Ig-like_dom_sf IPR013783, Ig-like_fold IPR003006, Ig/MHC_CS IPR003597, Ig_C1-set IPR011162, MHC_I/II-like_Ag-recog IPR014745, MHC_II_a/b_N IPR000353, MHC_II_b_N |
Pfami | View protein in Pfam PF07654, C1-set, 1 hit PF00969, MHC_II_beta, 1 hit |
SMARTi | View protein in SMART SM00407, IGc1, 1 hit SM00921, MHC_II_beta, 1 hit |
SUPFAMi | SSF48726, SSF48726, 1 hit SSF54452, SSF54452, 1 hit |
PROSITEi | View protein in PROSITE PS50835, IG_LIKE, 1 hit PS00290, IG_MHC, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | G3RPG3_GORGO | |
Accessioni | G3RPG3Primary (citable) accession number: G3RPG3 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | December 2, 2020 | |
This is version 58 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |