Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 56 (25 May 2022)
Sequence version 2 (28 Feb 2018)
Previous versions | rss
Add a publicationFeedback
Protein
Submitted name:

Uncharacterized protein

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-bindingARBA annotation
LigandMetal-bindingARBA annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projectionARBA annotation, Cytoplasm, CytoskeletonPROSITE-ProRule annotation, MembraneARBA annotation, MicrotubuleARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

PhosphoproteinARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000016292, Expressed in prefrontal cortex and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000024785

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini78 – 181Calponin-homology (CH)InterPro annotationAdd BLAST104
Domaini194 – 298Calponin-homology (CH)InterPro annotationAdd BLAST105
Domaini868 – 925SH3InterPro annotationAdd BLAST58
Domaini5083 – 5118EF-handInterPro annotationAdd BLAST36
Domaini5119 – 5154EF-handInterPro annotationAdd BLAST36
Domaini5159 – 5231GARInterPro annotationAdd BLAST73

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 47DisorderedSequence analysisAdd BLAST47
Regioni3625 – 3645DisorderedSequence analysisAdd BLAST21
Regioni4997 – 5022DisorderedSequence analysisAdd BLAST26
Regioni5247 – 5430DisorderedSequence analysisAdd BLAST184

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili245 – 265Sequence analysisAdd BLAST21
Coiled coili477 – 497Sequence analysisAdd BLAST21
Coiled coili502 – 529Sequence analysisAdd BLAST28
Coiled coili821 – 841Sequence analysisAdd BLAST21
Coiled coili1046 – 1066Sequence analysisAdd BLAST21
Coiled coili1403 – 1433Sequence analysisAdd BLAST31
Coiled coili1497 – 1517Sequence analysisAdd BLAST21
Coiled coili1522 – 1549Sequence analysisAdd BLAST28
Coiled coili1629 – 1663Sequence analysisAdd BLAST35
Coiled coili1793 – 1823Sequence analysisAdd BLAST31
Coiled coili2187 – 2214Sequence analysisAdd BLAST28
Coiled coili2234 – 2254Sequence analysisAdd BLAST21
Coiled coili2292 – 2312Sequence analysisAdd BLAST21
Coiled coili2397 – 2417Sequence analysisAdd BLAST21
Coiled coili2557 – 2577Sequence analysisAdd BLAST21
Coiled coili2616 – 2636Sequence analysisAdd BLAST21
Coiled coili2657 – 2691Sequence analysisAdd BLAST35
Coiled coili2808 – 2828Sequence analysisAdd BLAST21
Coiled coili2929 – 2970Sequence analysisAdd BLAST42
Coiled coili3133 – 3153Sequence analysisAdd BLAST21
Coiled coili3244 – 3264Sequence analysisAdd BLAST21
Coiled coili3897 – 3917Sequence analysisAdd BLAST21
Coiled coili4133 – 4160Sequence analysisAdd BLAST28
Coiled coili4912 – 4932Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi8 – 28Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi3629 – 3644Polar residuesSequence analysisAdd BLAST16
Compositional biasi5005 – 5022Polar residuesSequence analysisAdd BLAST18
Compositional biasi5266 – 5345Polar residuesSequence analysisAdd BLAST80
Compositional biasi5377 – 5430Polar residuesSequence analysisAdd BLAST54

Keywords - Domaini

Coiled coilSequence analysis, RepeatARBA annotation, SH3 domainPROSITE-ProRule annotationARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0516, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155824

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_253224_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3RJN1

Database of Orthologous Groups

More...
OrthoDBi
24858at2759

TreeFam database of animal gene trees

More...
TreeFami
TF322393

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 15 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.418.10, 2 hits
3.30.920.20, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR23169, PTHR23169, 8 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 8 potential isoforms that are computationally mapped.Show allAlign All

G3RJN1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSSSDEETLS ERSCRSERSC RSERSYRSER SGSLSPCPPG DTLPWNLPLH
60 70 80 90 100
EQKKRKSQDS VLDPAERAVV RVADERDRVQ KKTFTKWVNK HLMKVRKHIN
110 120 130 140 150
DLYEDLRDGH NLISLLEVLS GIKLPREKGR MRFHRLQNVQ IALDFLKQRQ
160 170 180 190 200
VKLVNIRNDD ITDGNPKLTL GLIWTIILHF QISDIYISGE SGDMSAKEKL
210 220 230 240 250
LLWTQKVTAG YTGIKCTNFS SCWSDGKMFN ALIHRYRPDL VDMERVQIQS
260 270 280 290 300
NRENLEQAFE VAERLGVTRL LDAEDVDVPS PDEKSVITYV SSIYDAFPKV
310 320 330 340 350
PEGGEGISAT EVDSRWQEYQ SRVDSLIPWI KQHTILMSDK TFPQNPVELK
360 370 380 390 400
ALYNQYIHFK ETEILAKERE KGRIEELYKL LEVWIEFGRI KLPQGYHPND
410 420 430 440 450
VEEEWGKLII EMLEREKSLR PAVERLELLL QIANKIQNGA LNCEEKLTLA
460 470 480 490 500
KNTLQADAAH LESGQPVQCE SDVIMYIQEC EGLIRQLQVD LQILRDENYY
510 520 530 540 550
QLEELAFRVM RLQDELVTLR LECTNLYRKG HFTSLELVPP STLTTTHLKA
560 570 580 590 600
EPLTKATHSS STSWFRKPMT RAELVAISSS EDEGNLRFVY ELLSWVEEMQ
610 620 630 640 650
MKLERAEWGS DLPSVELQLE TQQHIHTSVE ELGSSVKEAR LYEGKISQNF
660 670 680 690 700
HTSYAETLGK LETQYCKLKE TSSFRMRHLQ SLHKFVSRAT AELIWLNEKE
710 720 730 740 750
EEELAYDWSD NNSNISAKRN YFSELTMELE EKQDVFRSLQ DTAELLSLEN
760 770 780 790 800
HPAKQTVEAY SAAVQSQLQW MKQLCLCVEQ HVKENTAYFQ FFSDARELES
810 820 830 840 850
FLRNLQDSIK RKYSCDHNTS LSRLEDLLQD SMDEKEQLIQ SKSSVASLVG
860 870 880 890 900
RSKTIVQLKP RSPDHVLKNT ISVKAVCDYR QIEITICKND ECVLEDNSQR
910 920 930 940 950
TKWKVISPTG NEAMVPSVCF LIPPPNKDAI EMASRVEQSY QKVMALWHQL
960 970 980 990 1000
HVNTKSLISW NYLRKDLDLV QTWNLEKLRS SAPGECHQVM KNLQAHYEDF
1010 1020 1030 1040 1050
LQDSRDSVLF SVADRLRLEE EVEACKARFQ HLMKSMENED KEETVAKMYI
1060 1070 1080 1090 1100
SELKNIRLRL EEYEQRVVKR IQSLASSRTD RDARQDNALR IAEQEHTQED
1110 1120 1130 1140 1150
LQQLRSDLDA VSMKCDSFLH QSPSSSSVPT LRSELNLLVE KMDHVYGLST
1160 1170 1180 1190 1200
VYLNKLKTVD VIARSIQDAE LLVKGYEIKL SQEEAVLADL SALEAHRSTL
1210 1220 1230 1240 1250
RHWLSDVKDK NSVFSVLDEE IAKAKAVAEQ MSRLTPERNL DLEHYQEKGS
1260 1270 1280 1290 1300
QLQERWHRVI AQLEIRQSEL ESIQEVLGDY RACHGTLIKW IEETTAQQEM
1310 1320 1330 1340 1350
MKPGQAEDSR VLSEQLSQQT ALFAEIERNQ TKLDQCQKFS QQYSTIVKDY
1360 1370 1380 1390 1400
ELQLMTYKAF VESQQKSPGK RRRMLSSSDA ITQEFMDLRT RYTALVTLTT
1410 1420 1430 1440 1450
QHVKYISDAL RRLEEEEKVV EEEKQEHVEK VKELLGWVST LARNTQGKAT
1460 1470 1480 1490 1500
SSETKESTDI EKAILEQQVL SEELTTKKEQ VSEAIKTSQI FLAKHGHKLS
1510 1520 1530 1540 1550
EKEKKQISEQ LNALNKAYHD LCDGSANQLQ QLQSQLAHQT EQKTLQKQQN
1560 1570 1580 1590 1600
TCHQQLEDLC SWVGQAERAL AGHQGRTTQQ DLSALQKNQS DLKDLQDDIQ
1610 1620 1630 1640 1650
NRATSFATVV KDIEGFMEEN QTKLSPRELT ALREKLHQAK EQYEALQEQT
1660 1670 1680 1690 1700
RVAQKELEEA VTSALQQETE KSKAAKELAE NKKKIDALLD WVTSVGSSGG
1710 1720 1730 1740 1750
QLLTNLPGME QLSGASLEKG ALDTTDGYMG VNQAPEKLDK QCEMMKARHQ
1760 1770 1780 1790 1800
ELLSQQQNFI LATQSAQAFL DQHGHNLTPE EQQMLQQKLG ELKEQYSTSL
1810 1820 1830 1840 1850
AQSEAELKQV QTLQDELQKF LQDHREFESW LERSEKELEN MHKGGSSPEA
1860 1870 1880 1890 1900
LPSLLKRQGS FSEDVISHKG DLRFVTISGQ KVLDMENSFK EGKEPSEIGN
1910 1920 1930 1940 1950
LVKDKLKDAT ERYTALHSKC TRLGSHLNML LGQYHQFQNS ADSLQAWMQT
1960 1970 1980 1990 2000
CEANVEKLLS DTVASDPGVL QEQLATTKQL QEELAEHQVP VEKLQKVARD
2010 2020 2030 2040 2050
IMEIEGEPAP DHRHVQETTD SILSHFQSLS YSLAERSSLL QKAIAQSQSV
2060 2070 2080 2090 2100
QESLESLLQS IGEVEQNLEG KQVSSLSSGV IQEALATNMK LKQDIARQKS
2110 2120 2130 2140 2150
SLEATREMVT RFMETADSTT AAVLQGKLAE VSQRFEQLCL QQQEKESSLK
2160 2170 2180 2190 2200
KLLPQAEMFE HLSGKLQQFM ENKSRMLASG NQPDQDITHF FQQIQELNLE
2210 2220 2230 2240 2250
MEDQQENLDT LEHLVTELSS CGFALDLCQH QDRVQNLRKD FTELQKTVKE
2260 2270 2280 2290 2300
REKDASSCQE QLDEFRKLVR TFQKWLKETE GSIPPTETSM SAKELEKQIE
2310 2320 2330 2340 2350
HLKSLLDDWA SKGTLVEEIN CKGTSLENLI MEITAPDSQG KTGSILPSVG
2360 2370 2380 2390 2400
SSVGSVNGYH TCKDLTEIQC DMSDVNLKYE KLGGVLHERQ ESLQAILNRM
2410 2420 2430 2440 2450
EEVHKEANSV LQWLESKEEV LKSMDAMSSP TKTETVKAQA ESNKAFLAEL
2460 2470 2480 2490 2500
EQNSPKIQKV KEALAGLLVT YPNSQEAENW KKIQEELNSR WERATEVTVA
2510 2520 2530 2540 2550
RQRQLEESAS HLACFQAAES QLRPWLMEKE LMMGVLGPLS IDPNMLNAQK
2560 2570 2580 2590 2600
QQVQFMLKEF EARRQQHEQL NEAAQGILTG PGDVSLSTSQ VQKELQSINQ
2610 2620 2630 2640 2650
KWVELTDKLN SRSSQIDQAI VKSTQYQELL QDLSEKVRAV GQRLSVQSAI
2660 2670 2680 2690 2700
STQPEAVKQQ LEETSEIRSD LEQLDHEVKE AQTLCDELSV LIGEQYLKDE
2710 2720 2730 2740 2750
LKKRLETVAL PLQGLEDLAA DRMNRLQAAL ASTQQFQQMF DELRTWLDDK
2760 2770 2780 2790 2800
QSQQAKNCPI SAKLERLQSQ LQENEEFQKS LNQHSGSYEV IVAEGESLLL
2810 2820 2830 2840 2850
SVPPGEEKRT LQNQLVELKN HWEELSKKTA DRQSRLKDCM QKAQKYQWHV
2860 2870 2880 2890 2900
EDLVPWIEDC KAKMSELRVT LDPVQLESSL LRSKAMLSEV EKRRSLLEIL
2910 2920 2930 2940 2950
NSAADILINS SEADEDGIRD EKAGINQNVD AVTEELQAKT GSLEEMTQRL
2960 2970 2980 2990 3000
KEFQESFKNI EKKVEGAKHQ LEIFDALGSQ ACSNKNLEKL RAQQEMLQAL
3010 3020 3030 3040 3050
EPQVDYLRNF TQGLVEDAPD GSDASQLLHQ AEVAQQEFLE VKQRVNSGCV
3060 3070 3080 3090 3100
MMENKLEGIG QFHCRVREMF SQLADLDDEL DGMGAIGRDT DSLQSQIEDV
3110 3120 3130 3140 3150
RLFLNKIHVL KLDIEASEAE CRHMLEEEGT LDLLGLKREL EALNKQCGKL
3160 3170 3180 3190 3200
TERGKARQEQ LELTLGRVED FYRKLKGLND ATTAAEEAEA LQWVVGTEVE
3210 3220 3230 3240 3250
IINQQLADFK MFQKEQVDPL QMKLQQVNGL GQGLIQSAGK DCDVQGLEHD
3260 3270 3280 3290 3300
MEEINARWNT LNKKVAQRIA QLQEALLHCG KFQDALEPLL SWLADTEELI
3310 3320 3330 3340 3350
ANQKPPSAEY KVVKAQIQEQ KLLQRLLDDR KATVDMLQAE GGRIAQSAEL
3360 3370 3380 3390 3400
ADREKITGQL ESLESRWTEL LSKAAARQKQ LEDILVLAKQ FHETAEPISD
3410 3420 3430 3440 3450
FLSVTEKKLA NSEPVGTQTA KIQQQIIRHK ALEEDIENHA TDVHQAVKIG
3460 3470 3480 3490 3500
QSLSSLTSPA EQGVLSEKID SLQARYSEIQ DRCCRKAALL DQALSNARLF
3510 3520 3530 3540 3550
GEDEVEVLNW LAEVEDKLSS VFVKDFKQDV LHRQHADHLA LNEEIVNRKK
3560 3570 3580 3590 3600
NVDQAIKNGQ ALLKQTTGEE VLLIQEKLDG IKTRYTDITV TSSKALRTLE
3610 3620 3630 3640 3650
QARQLATKFQ STYEELTGWL REVEEELATS GGQSPTGEQI PQFQQRQKEL
3660 3670 3680 3690 3700
KKEVMEHRLV LDTVNEVSRA LLELVPWRAR EGLDKLVSDA NEQYKLVSDT
3710 3720 3730 3740 3750
IGQRVDEIDA AIQRSQQYEQ AADAELAWVA ETKRKLMALG PIRLEQDQTT
3760 3770 3780 3790 3800
AQLQVQKAFS IDIIRHKDSM DELFSHRSEI FGTCGEEQKT VLQEKTESLI
3810 3820 3830 3840 3850
QQYEAISLLN SERYARLERA QVLVNQFWET YEELSPWIEE TQALIAQLPA
3860 3870 3880 3890 3900
PAIDHEQLRQ QQEEMRQLRE SIAEHKPHID KLLKIGPQLK ELNPEEGEMV
3910 3920 3930 3940 3950
EEKYQKAENM YAQIKEEVRQ RALALDEAVS QSTQITEFHD KIEPMLETLE
3960 3970 3980 3990 4000
NLSSRLRMPP LIPAEVDKIR ECISDNKSAT VELEKLQPSF EALKRRGEEL
4010 4020 4030 4040 4050
IGRSQGADKD LAAKEIQDKL DQMVFFWEDI KARAEEREIK FLDVLELAEK
4060 4070 4080 4090 4100
FWYDMAALLT TIKDTQDIVH DLESPGIDPS IIKQQVEAAE TIKEETDGLH
4110 4120 4130 4140 4150
EELEFIRILG ADLIFACGET EKPEVRKSID EMNNAWENLN KTWKERLEKL
4160 4170 4180 4190 4200
EDAMQAAVQY QDTLQAMFDW LDNTVIKLCT MPPVGTDLNT VKDQLNEMKE
4210 4220 4230 4240 4250
FKVEVYQQQI EMEKLNHQGE LMLKKATDET DRDIIREPLT ELKHLWENLG
4260 4270 4280 4290 4300
EKIAHRQHKL EGALLALGQF QHALEELMSW LTHTEELLDA QRPISGDPKV
4310 4320 4330 4340 4350
IEVELAKHHV LKNDVLAHQA TVETVNKAGN ELLESSAGDD ASSLRSRLET
4360 4370 4380 4390 4400
MNQCWESVLQ KTEEREQQLQ STLQQAQGFH SEIEDFLLEL TRMESQLSAS
4410 4420 4430 4440 4450
KPTGGLPETA REQLDTHMEL YSQLKAKEET YNQLLDKGRL MLLSRDDSGS
4460 4470 4480 4490 4500
GSKTEQSVAL LEQKWHVVSS KMEERKSKLE EALNLATEFQ NSLQEFINWL
4510 4520 4530 4540 4550
TLAEQSLNIA SPPSLILNTV LSQIEEHKVF ANEVNAHRDQ IIELDQTGNQ
4560 4570 4580 4590 4600
LKFLSQKQDV VLIKNLLVSV QSRWEKVVQR SIERGRSLDD ARKRAKQFHE
4610 4620 4630 4640 4650
AWKKLIDWLE DAESHLDSEL EISNDPDKIK LQLSKHKEFQ KTLGGKQPVY
4660 4670 4680 4690 4700
DTTIRTGRAL KEKTLLPEDT QKLDNFLGEV RDKWDTVCGK SVERQHKLEE
4710 4720 4730 4740 4750
ALLFSGQFMD ALQALVDWLY KVEPQLAEDQ PVHGDLDLVM NLMDAHKVFQ
4760 4770 4780 4790 4800
KELGKRTGTV QVLKRSGREL IENSRDDTTW VKGQLQELST RWDTVCKLSV
4810 4820 4830 4840 4850
SKQSRLEQAL KQAEVFRDTV HMLLEWLSEA EQTLRFRGAL PDDTEALQSL
4860 4870 4880 4890 4900
IDTHKEFMKK VEEKRVDVNS AVAMGEVILA VCHPDCITTI KHWITIIRAR
4910 4920 4930 4940 4950
FEEVLTWAKQ HQQRLETALS ELVANAELLE ELLAWIQWAE TTLIQRDQEP
4960 4970 4980 4990 5000
IPQNIDRVKA LIAEHQTFME EMTRKQPDVD RVTKTYKRKI IEPTHAPFIE
5010 5020 5030 5040 5050
KSRSGGRKSL SQPTAPPMPI LSQSEAKNPR INQLSARWQQ VWLLALERQR
5060 5070 5080 5090 5100
KLNDALDRLE ELKEFANFDF DVWRKKYMRW MNHKKSRVMD FFRRIDKDQD
5110 5120 5130 5140 5150
GKITRQEFID GILASKFPTT KLEMTAVADI FDRDGDGYID YYEFVAALHP
5160 5170 5180 5190 5200
NKDAYRPTTD ADKIEDEVTR QVAQCKCAKR FQVEQIGENK YRFGDSQQLR
5210 5220 5230 5240 5250
LVRILRSTVM VRVGGGWMAL DEFLVKNDPC RARGRTNIEL REKFILPEGA
5260 5270 5280 5290 5300
SQGMTPFRSR GRRSKPSSRA ASPTRSSSSA SQSNHSCTSM PSSPATPASG
5310 5320 5330 5340 5350
TKVIPSSGSK LKRPTPTFHS SRTSLAGDTS NSSSPASTGA KTNRADPKKS
5360 5370 5380 5390 5400
ASRPGSRAGS RAGSRASSRR GSDASDFDLL ETQSACSDTS ESSAAGGQGN
5410 5420 5430
SRRGLNKPSK IPTMSKKTTT ASPRTPGPKR
Length:5,430
Mass (Da):620,189
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC500C97059930C62
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 8 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2Y844A0A2I2Y844_GORGO
Uncharacterized protein
7,590Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2Y462A0A2I2Y462_GORGO
Uncharacterized protein
7,553Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YAL4A0A2I2YAL4_GORGO
Uncharacterized protein
7,534Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YG61A0A2I2YG61_GORGO
Uncharacterized protein
7,386Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2ZMA6A0A2I2ZMA6_GORGO
Uncharacterized protein
7,553Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YUV6A0A2I2YUV6_GORGO
EF-hand domain-containing protein
630Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3S9L9G3S9L9_GORGO
Calponin-homology (CH) domain-conta...
1,061Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YDC2A0A2I2YDC2_GORGO
Uncharacterized protein
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030002559 Genomic DNA No translation available.
CABD030002560 Genomic DNA No translation available.
CABD030002561 Genomic DNA No translation available.
CABD030002562 Genomic DNA No translation available.
CABD030002563 Genomic DNA No translation available.
CABD030002564 Genomic DNA No translation available.
CABD030002565 Genomic DNA No translation available.
CABD030002566 Genomic DNA No translation available.
CABD030002567 Genomic DNA No translation available.
CABD030002568 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_018871493.1, XM_019015948.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000016380; ENSGGOP00000015926; ENSGGOG00000022652

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101146907

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030002559 Genomic DNA No translation available.
CABD030002560 Genomic DNA No translation available.
CABD030002561 Genomic DNA No translation available.
CABD030002562 Genomic DNA No translation available.
CABD030002563 Genomic DNA No translation available.
CABD030002564 Genomic DNA No translation available.
CABD030002565 Genomic DNA No translation available.
CABD030002566 Genomic DNA No translation available.
CABD030002567 Genomic DNA No translation available.
CABD030002568 Genomic DNA No translation available.
RefSeqiXP_018871493.1, XM_019015948.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000024785

Genome annotation databases

EnsembliENSGGOT00000016380; ENSGGOP00000015926; ENSGGOG00000022652
GeneIDi101146907

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
23499

Phylogenomic databases

eggNOGiKOG0516, Eukaryota
GeneTreeiENSGT00940000155824
HOGENOMiCLU_253224_0_0_1
InParanoidiG3RJN1
OrthoDBi24858at2759
TreeFamiTF322393

Gene expression databases

BgeeiENSGGOG00000016292, Expressed in prefrontal cortex and 6 other tissues

Family and domain databases

CDDicd00014, CH, 2 hits
cd00051, EFh, 1 hit
cd00176, SPEC, 15 hits
Gene3Di1.10.418.10, 2 hits
3.30.920.20, 1 hit
InterProiView protein in InterPro
IPR001589, Actinin_actin-bd_CS
IPR001715, CH-domain
IPR036872, CH_dom_sf
IPR041615, Desmoplakin_SH3
IPR041573, Desmoplakin_Spectrin-like
IPR011992, EF-hand-dom_pair
IPR018247, EF_Hand_1_Ca_BS
IPR002048, EF_hand_dom
IPR003108, GAR_dom
IPR036534, GAR_dom_sf
IPR043197, Plakin
IPR001452, SH3_domain
IPR018159, Spectrin/alpha-actinin
IPR002017, Spectrin_repeat
PANTHERiPTHR23169, PTHR23169, 8 hits
PfamiView protein in Pfam
PF00307, CH, 2 hits
PF13499, EF-hand_7, 1 hit
PF02187, GAS2, 1 hit
PF17902, SH3_10, 1 hit
PF00435, Spectrin, 18 hits
PF18373, Spectrin_like, 1 hit
SMARTiView protein in SMART
SM00033, CH, 2 hits
SM00054, EFh, 2 hits
SM00243, GAS2, 1 hit
SM00150, SPEC, 33 hits
SUPFAMiSSF143575, SSF143575, 1 hit
SSF47473, SSF47473, 1 hit
SSF47576, SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS00019, ACTININ_1, 1 hit
PS00020, ACTININ_2, 1 hit
PS50021, CH, 2 hits
PS00018, EF_HAND_1, 2 hits
PS50222, EF_HAND_2, 2 hits
PS51460, GAR, 1 hit
PS50002, SH3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3RJN1_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3RJN1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: May 25, 2022
This is version 56 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again