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Protein

Heparan-sulfate 6-O-sulfotransferase

Gene

HS6ST2

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.UniRule annotation

Catalytic activityi

3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 6-sulfate.UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionTransferaseUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Heparan-sulfate 6-O-sulfotransferaseUniRule annotation (EC:2.8.2.-UniRule annotation)
Gene namesi
Name:HS6ST2Imported
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome X

Subcellular locationi

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSGGOG00000014140

Interactioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000013794

Family & Domainsi

Sequence similaritiesi

Belongs to the sulfotransferase 6 family.UniRule annotation

Keywords - Domaini

Signal-anchorUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

GeneTreeiENSGT00390000013468
InParanoidiG3RE22
OMAiNYYYITI
OrthoDBiEOG091G08UD
TreeFamiTF312835

Family and domain databases

InterProiView protein in InterPro
IPR010635 Heparan_SO4-6-sulfoTrfase
IPR027417 P-loop_NTPase
IPR005331 Sulfotransferase
PANTHERiPTHR12812 PTHR12812, 1 hit
PfamiView protein in Pfam
PF03567 Sulfotransfer_2, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits

Sequencei

Sequence statusi: Complete.

G3RE22-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALPACAVRA FQPPRQPERG APARTTCPRR HSRVEAELAA SRPGSVAASV
60 70 80 90 100
RAGPPRGVSH GFHTRPLLDK PRKASSSLAG AACAPLFALL SRGRRRRMHV
110 120 130 140 150
LRRRWDLGSL CRALLTRGLA ALGHSLKHVL GAIFSKIFGP LASVGNMDEK
160 170 180 190 200
SNKLLLALVM LFLFAVIVLQ YVCPGTECQL LRLQAFSSPV PDPYRSEDES
210 220 230 240 250
SARFVPRYNF TRGDLLRKVD FDIKGDDLIV FLHIQKTGGT TFGRHLVRNI
260 270 280 290 300
QLEQPCECRV GQKKCTCHRP GKRETWLFSR FSTGWSCGLH ADWTELTSCV
310 320 330 340 350
PSVVDGKRDA RLRPSRWRIF QILDAASKDK RGSPNTNAGA NSPSSTKTRN
360 370 380 390 400
TSKSGKNFHY ITILRDPVSR YLSEWRHVQR GATWKASLHV CDGRPPTSEE
410 420 430 440 450
LPSCYTGDDW SGCPLKEFMD CPYNLANNRQ VRMLSDLTLV GCYNLSVMPE
460 470 480 490 500
KQRNKVLLES AKSNLKHMAF FGLTEFQRKT QYLFEKTFNM NFISPFTQYN
510 520 530 540 550
TTRASSVEIN EEIQKRIEGL NFLDMELYSY AKDLFLQRYQ FMRQKEHQEA
560 570 580 590 600
RRKRQEQRKF LKGRLLQTHF QSQGQGQSQN QNQNQNQSQN PNPNANQNLT
610 620 630 640
QNLMQNLTQS LSQKENRESP KQNSGKEQND NTSNGTNDYI GSVEKWR
Length:647
Mass (Da):73,559
Last modified:February 28, 2018 - v2
Checksum:i34D55720AD3D080E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030128380 Genomic DNA No translation available.
CABD030128381 Genomic DNA No translation available.
CABD030128382 Genomic DNA No translation available.
CABD030128383 Genomic DNA No translation available.
CABD030128384 Genomic DNA No translation available.
CABD030128385 Genomic DNA No translation available.
CABD030128386 Genomic DNA No translation available.
CABD030128387 Genomic DNA No translation available.
CABD030128388 Genomic DNA No translation available.
RefSeqiXP_018875357.1, XM_019019812.1

Genome annotation databases

EnsembliENSGGOT00000014188; ENSGGOP00000013794; ENSGGOG00000014140
GeneIDi101135929

Similar proteinsi

Entry informationi

Entry nameiG3RE22_GORGO
AccessioniPrimary (citable) accession number: G3RE22
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: May 23, 2018
This is version 37 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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