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Entry version 43 (26 Feb 2020)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

Apoptosis associated tyrosine kinase

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Apoptosis associated tyrosine kinaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei12 – 32HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000014076 Expressed in frontal cortex and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000013739

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini106 – 376Protein kinaseInterPro annotationAdd BLAST271

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni524 – 574DisorderedSequence analysisAdd BLAST51
Regioni584 – 603DisorderedSequence analysisAdd BLAST20
Regioni648 – 674DisorderedSequence analysisAdd BLAST27
Regioni687 – 711DisorderedSequence analysisAdd BLAST25
Regioni741 – 1177DisorderedSequence analysisAdd BLAST437
Regioni1228 – 1286DisorderedSequence analysisAdd BLAST59
Regioni1303 – 1355DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi659 – 674PolarSequence analysisAdd BLAST16
Compositional biasi812 – 835PolarSequence analysisAdd BLAST24
Compositional biasi843 – 862PolarSequence analysisAdd BLAST20
Compositional biasi876 – 890PolarSequence analysisAdd BLAST15
Compositional biasi956 – 970PolarSequence analysisAdd BLAST15
Compositional biasi1012 – 1028PolarSequence analysisAdd BLAST17
Compositional biasi1056 – 1073Pro-richSequence analysisAdd BLAST18
Compositional biasi1080 – 1103PolarSequence analysisAdd BLAST24
Compositional biasi1140 – 1156AcidicSequence analysisAdd BLAST17
Compositional biasi1250 – 1272PolarSequence analysisAdd BLAST23
Compositional biasi1318 – 1333PolarSequence analysisAdd BLAST16
Compositional biasi1334 – 1355PolyampholyteSequence analysisAdd BLAST22

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154244

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004618_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3RDX5

TreeFam database of animal gene trees

More...
TreeFami
TF332280

Family and domain databases

Conserved Domains Database

More...
CDDi
cd05087 PTKc_Aatyk1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR042817 LMTK1_c
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07714 Pkinase_Tyr, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00109 TYRKINASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56112 SSF56112, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

G3RDX5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
GAPLSELSWP SSLAVVAVSF SGLFAVIVLM LACLCCKKGG IGFKEFENAE
60 70 80 90 100
GDEYAADLAQ GSPATAAQNG PDVYVLPLTE VSLPMAKQPG RSVQLLKSTD
110 120 130 140 150
VGRHSLLYLK EIGHGWFGKV FLGEVNSGVS SAQVVVKELQ ASASVQEQMQ
160 170 180 190 200
FLEEVQPYRA LKHSNLLQCL AQCAEVTPYL LVMEFCPLGD LKGYLRSCRV
210 220 230 240 250
AESMAPDPLT LQRMACEVAC GILHLHRNNF VHSDLALRNC LLTADLTVKI
260 270 280 290 300
GDYGLAHCKY REDYFVTADQ LWVPLRWIAP ELVDEVHSNL LVVDQTKSGN
310 320 330 340 350
VWSLGVTIWE LFELGTQPYP QHSDQQVLAY AVREQQLKLP KPQLQLTLSD
360 370 380 390 400
RWYEVMQFCW LQPEQRPTAE EVHLLLSYLC AKGATEAEEE FERRWRSLRP
410 420 430 440 450
GGGGVGPGPG AAGPMLGGVV ELAAASSFPL LEQFAGDGFH ADGDDVLTVT
460 470 480 490 500
ETSRGLNFEY KWEAGRGAEA FPATLSPGRT ARLQELCAPD GAPPGVVPVL
510 520 530 540 550
SAHSPSLGSE YFIRLEETAP AAGHDPDCAG CAPSPPATAD QDDDSDGSTA
560 570 580 590 600
TSPAMEPLLG HGPPVDVPWG RGDHYPRRSL ARDLLCPSRS PSPSAGPLSL
610 620 630 640 650
AEGGAEDADW GVAAFCPPFF EDPLGTSPLG SSGAPPLPLT GENELEEVGA
660 670 680 690 700
RRAAQRGHWR SNVSANNNSG SRCPESWDPI SAGCHAEGCP SPKQTPRASP
710 720 730 740 750
EPGYPGEPLF GLQAASAQEP GCCPGLPPLC SAQGLAPAPC LVTPSWTETD
760 770 780 790 800
GSGGDHPQAE PKLATEAEGT AGPRLPLPSV PSPSQEGAPL PSEEASAPDA
810 820 830 840 850
PDALPDSPTP ATGGEVSATK LASALNGSSS SPEVEAPSSE DEDTAEATSG
860 870 880 890 900
IFTDTSSDGL QAERQDVVPA FHSLQKQVGT PDSLDSLDIP SSASDGGYEV
910 920 930 940 950
FSPSATGPSG GQPRALDSGY DTENYESPEF VLKEAQEGCE PQAFAELASE
960 970 980 990 1000
GEGPGPETRL STSLSGLNEK NPYRDSAYFS DLEAEAEAEA TSGPEKKCGG
1010 1020 1030 1040 1050
DQAPGPELGL PSTGQPSEQV SLSPGVSVEA QGSGPGEVLP PLLRLEGSSP
1060 1070 1080 1090 1100
EPSTCPSGLV PEPPEPQGPA EVRPGPSPSC SQFFLLTPVP LRSEGNSSEF
1110 1120 1130 1140 1150
QGPPGLLSGP APQKRMGGPG TPRAPHRLAL PGLPAALEGR PEEEEEDSED
1160 1170 1180 1190 1200
SDESDEELRC YSVQEPSEDS EEEAPAVPVV VAESQSARNL RSLLKMPSLL
1210 1220 1230 1240 1250
SEAFCEDLER KKKAVSFFDD VTVYLFDQES PTRELGEPFP GAKESPPTFL
1260 1270 1280 1290 1300
RGSPGSSSAP NRPQQADGSP NGSTAEEGGG FAWDDDFPLM PAKAAFAMAL
1310 1320 1330 1340 1350
DPAAPAPAAP TPAPFSRFTV SPAPTSRFSI THVSDSDAES KRGPEAGAGG

ESKEA
Length:1,355
Mass (Da):142,377
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i124A6D8E769C8E0B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030035730 Genomic DNA No translation available.
CABD030035731 Genomic DNA No translation available.
CABD030035732 Genomic DNA No translation available.
CABD030035733 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000014133; ENSGGOP00000013739; ENSGGOG00000014076

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030035730 Genomic DNA No translation available.
CABD030035731 Genomic DNA No translation available.
CABD030035732 Genomic DNA No translation available.
CABD030035733 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000013739

Genome annotation databases

EnsembliENSGGOT00000014133; ENSGGOP00000013739; ENSGGOG00000014076

Phylogenomic databases

GeneTreeiENSGT00940000154244
HOGENOMiCLU_004618_1_0_1
InParanoidiG3RDX5
TreeFamiTF332280

Gene expression databases

BgeeiENSGGOG00000014076 Expressed in frontal cortex and 6 other tissues

Family and domain databases

CDDicd05087 PTKc_Aatyk1, 1 hit
InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR042817 LMTK1_c
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR001245 Ser-Thr/Tyr_kinase_cat_dom
IPR008266 Tyr_kinase_AS
PfamiView protein in Pfam
PF07714 Pkinase_Tyr, 1 hit
PRINTSiPR00109 TYRKINASE
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00109 PROTEIN_KINASE_TYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3RDX5_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3RDX5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: February 26, 2020
This is version 43 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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