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Entry version 60 (26 Feb 2020)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

WD repeat domain 90

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
WD repeat domain 90Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000013796 Expressed in testis and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000013482

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini654 – 821WD_REPEATS_REGIONInterPro annotationAdd BLAST168
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati696 – 737WDPROSITE-ProRule annotationAdd BLAST42
Domaini924 – 1006WD_REPEATS_REGIONInterPro annotationAdd BLAST83
Domaini1154 – 1564WD_REPEATS_REGIONInterPro annotationAdd BLAST411
Repeati1433 – 1474WDPROSITE-ProRule annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1005 – 1071DisorderedSequence analysisAdd BLAST67

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

RepeatSAAS annotation, WD repeatPROSITE-ProRule annotationSAAS annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160173

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002454_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3RD84

Database of Orthologous Groups

More...
OrthoDBi
255317at2759

TreeFam database of animal gene trees

More...
TreeFami
TF329419

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR007714 CFA20_dom
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR030466 WDR90

The PANTHER Classification System

More...
PANTHERi
PTHR13720:SF24 PTHR13720:SF24, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05018 DUF667, 1 hit
PF00400 WD40, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00320 WD40, 20 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3RD84-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MARAWQHPFL NVFRHFRVDE WKRSAKQGDV AVVTDKTLKG AVYRIRGSVS
60 70 80 90 100
AANYIQLPKS STQSLGLTGR YLYVLFRPLP SKHFVIHLDV SAKDNQVIRV
110 120 130 140 150
SFSNLFKEFK STATWLQFPL VLEARTPQRD PVGLAPSGAR WTCLQLDLQD
160 170 180 190 200
VLLVYLNRCY GHLKSIRLCA SLLVRNLYTS DLCFEPAISG AQWAKLPVTP
210 220 230 240 250
MPREMAFPVP KGESWHDRYI HIRFPSESLK VPSKPIEKSC SPPEAVLLGP
260 270 280 290 300
GPQPLPCPVA SSKPVRFSVS PVVQTPSPTA SGRAPLAPRP FPEVSLSQEC
310 320 330 340 350
SDASNADGPG FHSLEPWARV EASDVHTAAA GTHVLTHESA EVPVARTGSS
360 370 380 390 400
KGFLPDPVLR LKGVIGFGGH STRQALWTPD GAAVVYPCHA VIVVLLVDTG
410 420 430 440 450
EQRFFLGHTD KVSALALDGS SSLLASAQAR APSMMRLWDF QTGRCLCLFR
460 470 480 490 500
SPMHVVCSLS FSDSGALLCG VGKDHHGRTM VMAWGTGQVG LSGEVVVLAK
510 520 530 540 550
AHTDFDVQAF RVTFFDETRM ASCGQGSVRL WRLRGRALRS CPVDLGEHHA
560 570 580 590 600
LQFTDLAFKQ ARDGCPEPSA AMLLVCSRSG HILEIDCQRM VVRHARRLLP
610 620 630 640 650
TRTPGGPHPQ KQTFSSGPGI AISSLSISPA MCAVGSEDGF LRLWPLDFSS
660 670 680 690 700
VLLEAEHEGP VSSVCVSPDG LRVLSATSSG HLGFLDTLSR VYHMLARSHT
710 720 730 740 750
APVLALAMEQ RRGQLATVSQ DRTVRIWDLA TLQQLYDFTS SEEAPCAVTF
760 770 780 790 800
HPTRPTFFCG FSSGAVRSFS LEAAEVLVEH TCHRGAVTGL TATPDGRLLF
810 820 830 840 850
SSCSRGSLAQ YSCADPQWHV LRVAADMVCP DAPASPSALA VSRDGRLLAF
860 870 880 890 900
VGPSRYTVTV MGSASLDELL RVDIGTLDLA SSRLDSAMAV CFGPAALGHL
910 920 930 940 950
LVSTSSNRVV VLDAVSGRII RELPGVHPEP CPSLTLSEDA RFLLIAAGRT
960 970 980 990 1000
IKVWDYATQA SSGPQVYIGH SEPVQAVAFS PDQQQVLSAG DAVFLWDVLA
1010 1020 1030 1040 1050
ATESDQSFPG APPACKTGPD TGPLEDAVSR ASELPRQQVP KPSQASPPRL
1060 1070 1080 1090 1100
GVCARPPEGG NGARDTRNSG APRTTYLASC KAFTPARVSC SPHSAKGTCL
1110 1120 1130 1140 1150
PPASGGWLRL KAVVGYSGNG RANMVWRPDT GFFAYTCGRL VVVEDLHSGA
1160 1170 1180 1190 1200
QQHWSGHSAE ISTLALSHSA QVLASASGRS STTAHCQIRV WDVSGGLCQH
1210 1220 1230 1240 1250
LIFPHSTTVL ALAFSPDDRL LVTLGDHDGH TLALWGTATY DLVSSTRLPE
1260 1270 1280 1290 1300
PVHGVAFNPW DAGELTCVGQ GTVTFWLLQQ RGADISLQVR REPVPEAVGA
1310 1320 1330 1340 1350
GELTSLCYGA PPLLYCGTSS GQVCVWDTRA GRCFLSWEAD DGGIGLLLFS
1360 1370 1380 1390 1400
GSRLVSGSST GRLRLWAVGA VSELRCKGSG ARSSSVFMEH ELVLDGAVVS
1410 1420 1430 1440 1450
ASFDDSMDMG IVGTTAGTLW FVSWAEGTST RLISGHRSKV NEVVFSPGES
1460 1470 1480 1490 1500
HCATCSEDGS VRVWALASME LVIQFQVLNQ SCLCLAWSPP CCGRPEQQRL
1510 1520 1530 1540 1550
AAGYGDGSLR IFSVSRTAME LKMHPHPVAL TTVAFSTDGQ TVLSGDKDGL
1560 1570 1580 1590 1600
VAVSHPRTGT TFRVLSDHQG APISTICVTC KECEDLGVEG TDLWLAASGD
1610 1620 1630 1640 1650
QRVSVWASDW LRNRCELVDW LSFPMPATTE TQGHLPPSLA AFCPWDGALL
1660 1670 1680 1690 1700
MYVGPGVYKE VIIYNLCQKQ VVEKIPLPFF AMSLSLSPGT HLLAVGFAEC
1710 1720 1730 1740 1750
MLRLVDCAMG TAQDFAGHDN AVHLCRFTPS ARLLFTAARN EILVWEVPGR
Length:1,750
Mass (Da):188,117
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iFE6749EE98FAFDFD
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2Z0C8A0A2I2Z0C8_GORGO
WD repeat domain 90
1,754Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2Z471A0A2I2Z471_GORGO
WD repeat domain 90
1,750Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YEG0A0A2I2YEG0_GORGO
WD repeat domain 90
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030098286 Genomic DNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
XP_018867324.1, XM_019011779.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000013870; ENSGGOP00000013482; ENSGGOG00000013796

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030098286 Genomic DNA No translation available.
RefSeqiXP_018867324.1, XM_019011779.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000013482

Genome annotation databases

EnsembliENSGGOT00000013870; ENSGGOP00000013482; ENSGGOG00000013796

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
197335

Phylogenomic databases

GeneTreeiENSGT00940000160173
HOGENOMiCLU_002454_0_0_1
InParanoidiG3RD84
OrthoDBi255317at2759
TreeFamiTF329419

Gene expression databases

BgeeiENSGGOG00000013796 Expressed in testis and 5 other tissues

Family and domain databases

Gene3Di2.130.10.10, 7 hits
InterProiView protein in InterPro
IPR007714 CFA20_dom
IPR011047 Quinoprotein_ADH-like_supfam
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
IPR030466 WDR90
PANTHERiPTHR13720:SF24 PTHR13720:SF24, 3 hits
PfamiView protein in Pfam
PF05018 DUF667, 1 hit
PF00400 WD40, 2 hits
SMARTiView protein in SMART
SM00320 WD40, 20 hits
SUPFAMiSSF50978 SSF50978, 1 hit
SSF50998 SSF50998, 3 hits
PROSITEiView protein in PROSITE
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 2 hits
PS50294 WD_REPEATS_REGION, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3RD84_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3RD84
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: February 26, 2020
This is version 60 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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Main funding by: National Institutes of Health

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