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Entry version 62 (26 Feb 2020)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

HECT and RLD domain containing E3 ubiquitin protein ligase family member 1

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei4737Glycyl thioester intermediatePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferaseSAAS annotation
Biological processUbl conjugation pathwayPROSITE-ProRule annotationSAAS annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
HECT and RLD domain containing E3 ubiquitin protein ligase family member 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000013126 Expressed in prefrontal cortex and 5 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000012839

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati372 – 421RCC1PROSITE-ProRule annotationAdd BLAST50
Repeati422 – 476RCC1PROSITE-ProRule annotationAdd BLAST55
Repeati477 – 529RCC1PROSITE-ProRule annotationAdd BLAST53
Repeati530 – 579RCC1PROSITE-ProRule annotationAdd BLAST50
Repeati581 – 632RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati633 – 683RCC1PROSITE-ProRule annotationAdd BLAST51
Repeati684 – 736RCC1PROSITE-ProRule annotationAdd BLAST53
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2002 – 2193B30.2/SPRYInterPro annotationAdd BLAST192
Domaini3381 – 3741WD_REPEATS_REGIONInterPro annotationAdd BLAST361
Repeati3381 – 3422WDPROSITE-ProRule annotationAdd BLAST42
Repeati3579 – 3610WDPROSITE-ProRule annotationAdd BLAST32
Repeati3700 – 3741WDPROSITE-ProRule annotationAdd BLAST42
Repeati3954 – 4002RCC1PROSITE-ProRule annotationAdd BLAST49
Repeati4003 – 4057RCC1PROSITE-ProRule annotationAdd BLAST55
Repeati4058 – 4109RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4110 – 4161RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4163 – 4214RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4215 – 4266RCC1PROSITE-ProRule annotationAdd BLAST52
Repeati4267 – 4318RCC1PROSITE-ProRule annotationAdd BLAST52
Domaini4427 – 4774HECTInterPro annotationAdd BLAST348

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni125 – 154DisorderedSequence analysisAdd BLAST30
Regioni1322 – 1341DisorderedSequence analysisAdd BLAST20
Regioni1346 – 1379DisorderedSequence analysisAdd BLAST34
Regioni1397 – 1432DisorderedSequence analysisAdd BLAST36
Regioni1466 – 1485DisorderedSequence analysisAdd BLAST20
Regioni1503 – 1530DisorderedSequence analysisAdd BLAST28
Regioni1864 – 1886DisorderedSequence analysisAdd BLAST23
Regioni2257 – 2286DisorderedSequence analysisAdd BLAST30
Regioni2407 – 2497DisorderedSequence analysisAdd BLAST91
Regioni2617 – 2675DisorderedSequence analysisAdd BLAST59
Regioni2692 – 2752DisorderedSequence analysisAdd BLAST61
Regioni2798 – 2876DisorderedSequence analysisAdd BLAST79
Regioni3193 – 3212DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi131 – 152PolarSequence analysisAdd BLAST22
Compositional biasi1325 – 1341PolyampholyteSequence analysisAdd BLAST17
Compositional biasi1346 – 1364PolyampholyteSequence analysisAdd BLAST19
Compositional biasi1470 – 1485PolarSequence analysisAdd BLAST16
Compositional biasi2407 – 2436PolyampholyteSequence analysisAdd BLAST30
Compositional biasi2437 – 2479PolarSequence analysisAdd BLAST43
Compositional biasi2480 – 2497PolyampholyteSequence analysisAdd BLAST18
Compositional biasi2622 – 2669PolarSequence analysisAdd BLAST48
Compositional biasi2692 – 2743PolarSequence analysisAdd BLAST52
Compositional biasi2855 – 2871PolarSequence analysisAdd BLAST17

Keywords - Domaini

RepeatSAAS annotation, WD repeatPROSITE-ProRule annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155907

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000091_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3RBI4

TreeFam database of animal gene trees

More...
TreeFami
TF106426

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00078 HECTc, 1 hit
cd12881 SPRY_HERC1, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.130.10.10, 1 hit
2.130.10.30, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003877 SPRY_dom
IPR035768 SPRY_HERC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00632 HECT, 1 hit
PF00415 RCC1, 10 hits
PF00622 SPRY, 1 hit
PF00400 WD40, 2 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00633 RCCNDNSATION

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00119 HECTc, 1 hit
SM00449 SPRY, 1 hit
SM00320 WD40, 5 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49899 SSF49899, 1 hit
SSF50978 SSF50978, 1 hit
SSF50985 SSF50985, 2 hits
SSF56204 SSF56204, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50237 HECT, 1 hit
PS00626 RCC1_2, 4 hits
PS50012 RCC1_3, 14 hits
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

G3RBI4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATMIPPVKL KWLEHLNSSW ITEDSESIAT REGVAVLYSK LVSNKEVVPL
60 70 80 90 100
PQQVLCLKGP QLPDFERESL SSDEQDHYLD ALLSSQLALA KMVCSDSPFA
110 120 130 140 150
GALRKRLLVL QRVFYALSNK YHDKGKVKQQ QHSPESSSGS ADVHSVSERP
160 170 180 190 200
RSSTDALIEM GVRTGLSLLF ALLRQSWMMP VSGPGLSLCN DVIHTAIEVV
210 220 230 240 250
SSLPPLSLAN ESKIPPMGLD CLSQVTTFLK GVTIPNSGAD TLGRRLASEL
260 270 280 290 300
LLGLAAQRGS LRYLLEWIEM ALGASAVVHT MEKSKLLSSQ EGMISFDCFM
310 320 330 340 350
TILMQMRRSL GSSADRSQWR EPTRTSDGLC SLYEAALCLF EEVCRMASDY
360 370 380 390 400
SRTCASPDSI QTGDAPIVSE TCEVYVWGSN SSHQLVEGTQ EKILQPKLAP
410 420 430 440 450
SFSDAQTIEA GQYCTFVIST DGSVRACGKG SYGRLGLGDS NNQSTLKKLT
460 470 480 490 500
FEPHRSIKKV SSSKGSDGHT LAFTTEGEVF SWGDGDYGKL GHGNSSTQKY
510 520 530 540 550
PKLIQGPLQG KVVVCVSAGY RHSAAVTEDG ELYTWGEGDF GRLGHGDSNS
560 570 580 590 600
RNIPTLVKDI SNVGEVSCGS SHTIALSKDG RTVWSFGGGD NGKLGHGDTN
610 620 630 640 650
RVYKPKVIEA LQGMFIRKVC AGSQSSLALT STGQVYAWGC GACLGCGSSE
660 670 680 690 700
ATALRPKLIE ELAATRIVDV SIGDSHCLAL SHDNEVYAWG NNSMGQCGQG
710 720 730 740 750
NSTGPITKPK KVSGLDGIAI QQISAGTSHS LAWTALPRDR QVVAWHRPYC
760 770 780 790 800
VDLEESTFSH LRSFLERYCD KINSEIPPLP FPSSREHHSF LKLCLKLLSN
810 820 830 840 850
HLALALAGGV ATSILGRQAG PLRNLLFRLM DSTVPDEIQE VVIETLSVGA
860 870 880 890 900
TMLLPPLRER MELLHSLLPQ GPDRWESLSK GQRMQLDIIL TSLQDHTHVA
910 920 930 940 950
SLLGYSSPSD AADLSSVCTG YGNLSDQPYG TQSCHPDTHL AEILMKTLLR
960 970 980 990 1000
NLGFYTDQAF GELEKNSDKF LLGTSSSENS QPAHLHELLC SLQKQLLAFC
1010 1020 1030 1040 1050
HINNISENSS SVALLHKHLQ LLLPHATDIY SRSANLLKES PWNGSVGEKL
1060 1070 1080 1090 1100
RDVIYVSAAG SMLCQIVNSL LLLPVSVARP LLSYLLDLLP PLDCLNRLLP
1110 1120 1130 1140 1150
AADLLEDQEL QWPLHGGPEL IDPAGLPLPQ PAQSWVWLVD LERTIALLIG
1160 1170 1180 1190 1200
RCLGGMLQGS PVSPEEQDTA YWMKTPLFSD GVEMDTPQLD KCMSCLLEVA
1210 1220 1230 1240 1250
LSGNEEQKPF DYKLRPEIAV YVDLALGCSK EPARSLWISM QDYAVSKDWD
1260 1270 1280 1290 1300
SATLSNESLL DTVSRFVLAA LLKHTNLLSQ ACGESRYQPG KHLSEVYRCV
1310 1320 1330 1340 1350
YKVRSRLLAC KNLELIQTRS SSRDRWLSEN QDSADVDPQE HSFTRTIDEE
1360 1370 1380 1390 1400
AEMEEQAERD REEGHPEPED EEEEREHEVM TAGKIFQCFL SAREVARSRD
1410 1420 1430 1440 1450
RDRMNSGAGS GARADDPPPQ SQQERRVSTD LPEGQDVYTA ACNSVIHRCA
1460 1470 1480 1490 1500
LLILGVSPVI EELQKRREEG QLQQPSTSAS EGGGLMTRSE SLTAESRLVH
1510 1520 1530 1540 1550
TSPNYRLIKS RSESDLSQPE SDEEGYTLSG RRNVDLDLAA SHRKRGPMHS
1560 1570 1580 1590 1600
QLESLSDSWA RLKHSRDWLC NSSYSFESDF DLTKSLGVHT LIENVVSFVS
1610 1620 1630 1640 1650
GDVGNAPGFK EPEESMSTSP QASIIAMEQQ QLRAELRLEA LHQILVLLSG
1660 1670 1680 1690 1700
MEEKGSISLA GSRLSSGFQS STLLTSVRLQ FLAGCFGLGT VGHTGAKGES
1710 1720 1730 1740 1750
GRLHHYQDGI RAAKRNIQIE IQVAVHKIYQ QLSATLERAL QANKHHIEAQ
1760 1770 1780 1790 1800
QRLLLVTVFA LSVHYQPVDV SLAISTGLLN VLSQLCGTDT MLGQPLQLLP
1810 1820 1830 1840 1850
KTGVSQLSTA LKVASTRLLQ ILAITTGTYA DKLSPKVVQS LLDLLCSQLK
1860 1870 1880 1890 1900
NLLSQTGVLH MASFGEGEQE DGEEEEKKVD SSGETEKKDF RAALRKQHAA
1910 1920 1930 1940 1950
ELHLGDFLVF LRRVVSSKAI QSKMASPKWT EVLLNIASQK CSSGIPLVGN
1960 1970 1980 1990 2000
LRTRLLALHV LEAVLPACES GVEDDQMAQI VERLFSLLSD CMWETPIAQA
2010 2020 2030 2040 2050
KHAIQIKEKE QEIKLQKQGE LEEEDENLPI QEVSFDPEKA QCCLVENGQI
2060 2070 2080 2090 2100
LTHGSGGKGY GLASTGVTSG CYQWKFYIVK ENRGNEGTCV GVSRWPVHDF
2110 2120 2130 2140 2150
NHRTTSDMWL YRAYSGNLYH NGEQTLTLSS FTQGDFITCV LDMEARTISF
2160 2170 2180 2190 2200
GKNGEEPKLA FEDVDAAELY PCVMFYSSNP GEKVKICDMQ MRGTPRDLLP
2210 2220 2230 2240 2250
GDPICSPVAA VLAEATIQLI RILHRTDRWT YCINKKMMER LHKIKICIKE
2260 2270 2280 2290 2300
SGQKLKKSRS VQSREENEMR EEKESKEEEK GKHTRHGLAD LSELQLRTLC
2310 2320 2330 2340 2350
IEVWPVLAVI GGVDAGLRVG GRCVHKQTGR HATLLGVVKE GSTSAKVQWD
2360 2370 2380 2390 2400
EAEITISFPT FWSPSDTPLY NLEPCEPLPF DVARFRGLTA SVLLDLTYLT
2410 2420 2430 2440 2450
GIHEDMGKQS TKRHEKKHRH ESEEKGDVEQ KPESESTLDM RTGLTSDDVK
2460 2470 2480 2490 2500
SQSTTSSKSE NEIASFSLDP TLPSVESQHQ ITEGKRKNHE HMSKNHDVAQ
2510 2520 2530 2540 2550
SEIRAVQLSY LYLGAMKSLS ALLGCSKYAE LLLIPKVLAE NGHNSDCASS
2560 2570 2580 2590 2600
PVVHEDVEMR AALQFLMRHM VKRAVMRSPI KRALGLADLE RAQAMIYKLV
2610 2620 2630 2640 2650
VHGLLEDQFG GKIKQEIDQQ AEESDPAQQA QTPVTTSPSA SSTTSFMSSS
2660 2670 2680 2690 2700
LEDTTTATTP VTDTETVPAS ESPGVMPLSL LRQMFSSYPT TTVLPTRRAQ
2710 2720 2730 2740 2750
TPPISSLPTS PSDEVGRRQS LTSPDSQSAR PANRTALSDP SSRLSTSPPP
2760 2770 2780 2790 2800
PAIAVPLLEM GFSLRQIAKA MEATGARGEA DAQNITVLAM WMIEHPGHED
2810 2820 2830 2840 2850
EEEPQSGSTA DSRHGAAVLG SGGKSNDPCY LQSPGDIPSA DAAEMEEGFS
2860 2870 2880 2890 2900
ESPDNLDHTE NAASGSGPSA RGRSAVTRRH KFDLAARTLL ARAAGLYRSV
2910 2920 2930 2940 2950
QAHRNQSRRE GISLQQDPGA LYDFNLDEEL EIDLDDEAME AMFGQDLTSD
2960 2970 2980 2990 3000
NDILGMWIPE VLDWPTWHVC ESEDREEVVV CELCECSVVS FNQHMKRNHP
3010 3020 3030 3040 3050
GCGRSANRQG YRSNGSYVDG WFGGECGSGN PYYLLCGTCR EKYLALKTKS
3060 3070 3080 3090 3100
KSTSTERYLE IVPPEDTSYL KSWELDPLGA SVAMVTATNS MEETLMQIGC
3110 3120 3130 3140 3150
HGSVEKSSSG RITLGEQAAA LANPHDRVVA LRRVTAAAQV LLARTMVMRA
3160 3170 3180 3190 3200
LSLLSVSGSS CSLAAGLESL GLTDIRTLVR LMCLAAAGRA GLSTSPSAMA
3210 3220 3230 3240 3250
STSERSRGGH SKANKPISCL AYLSTAVGCL ASNAPSAAKL LVQLCTQNLI
3260 3270 3280 3290 3300
SAATGVNLTT VDDSVQRKFL PSFLRGIAEE NKLVTSPNFV VTQALVALLA
3310 3320 3330 3340 3350
DKGAKLRPNY DKSEVEKKGP LELANALAAC CLSSRLSSQH RQWAAQQLVR
3360 3370 3380 3390 3400
TLAAHDRDNQ TTLQTLADMG GDLRKCSFIK LEAHQNRVMT CVWCNKKGLL
3410 3420 3430 3440 3450
ATSGNDGTIR VWNVTKKQYS LQQTCVFNRL EGDAEESLGS PSDPSFSPVS
3460 3470 3480 3490 3500
WSISGKYLAG ALEKMVNIWQ VNGGKGLVDI QPHWVSALAW PEEGPATAWS
3510 3520 3530 3540 3550
GESPELLLVG RMDGSLGLIE VVDVSTMHRR ELEHCYRKDV SVTCIAWFSE
3560 3570 3580 3590 3600
DRPFAVGYFD GKLLLGTKEP LEKGGIVLID AHKDTLTSMK WDPTGHILMT
3610 3620 3630 3640 3650
CAKEDSVKLW GSISGCWRCL HSLCHPSIVN GIAWCRLPGK GSKLQLLMAT
3660 3670 3680 3690 3700
GCQSGLVCVW RIPQDTTQTN VTSAEGWWDH ESNCQDGYRK SSGAKCVYQL
3710 3720 3730 3740 3750
RGHITPVRTV AFSSDGLALV SGGLGGLMNI WSLRDGSVLQ TVVIGSGAIQ
3760 3770 3780 3790 3800
TTVWIPEVGV AACSNRSKDV LVVNCTAEWA AANHVLATCR TALKQQGVLG
3810 3820 3830 3840 3850
LNMAPCMRAF LERLPMMLQE QYAYEKPHVV CGDQLVHSPY MQCLASLAVG
3860 3870 3880 3890 3900
LHLDQLLCNP PVPPHHQNCL PDPASWNPNE WAWLECFSTT IKAAEALTNG
3910 3920 3930 3940 3950
AQFPESFTVP DLEPVPEDEL VFLMDNSKWI NGMDEQIMSW ATSRPEDWHL
3960 3970 3980 3990 4000
GGKCDVYLWG AGRHGQLAEA GRNVMVPAAA PSFSQAQQVI CGQNCTFVIQ
4010 4020 4030 4040 4050
ANGTVLACGE GSYGRLGQGN SDDLHVLTVI SALQGFVVTQ LVTSCGSDGH
4060 4070 4080 4090 4100
SMALTESGEV FSWGDGDYGK LGHGNSDRQR RPRQIEALQG EEVVQMSCGF
4110 4120 4130 4140 4150
KHSAVVTSDG KLFTFGNGDY GRLGLGNTSN KKLPERVTAL EGYQIGQVAC
4160 4170 4180 4190 4200
GLNHTLAVSA DGSMVWAFGD GDYGKLGLGN STAKSSPQKI DVLCGIGIKK
4210 4220 4230 4240 4250
VACGTQFSVA LTKDGHVYTF GQDRLIGLPE GRARNHNRPQ QIPVLAGVII
4260 4270 4280 4290 4300
EDVAVGAEHT LALASNGDVY AWGSNSEGQL GLGHTNHVRE PTLVTGLQGK
4310 4320 4330 4340 4350
NVRQISAGRC HSAAWTAPPV PPRRSAHHSL PKCWDYRHEP LRPAKIMYVL
4360 4370 4380 4390 4400
QNSTSHYNAG TWGIVQGQLR PLLAPRVYTL PMVRSIGKTM VQGKNYGPQI
4410 4420 4430 4440 4450
TVKRISTRGR KCKPIFVQIA RQVVKLNASD LRLPSRAWKV KLVGEGADDA
4460 4470 4480 4490 4500
GGVFDDTITE MCQELETGIV DLLIPSPNAT AEVGYNRDRF LFNPSACLDE
4510 4520 4530 4540 4550
HLMQFKFLGI LMGVAIRTKK PLDLHLAPLV WKQLCCVPLT LEDLEEVDLL
4560 4570 4580 4590 4600
YVQTLNSILH IEDSGITEES FHEMIPLDSF VGQSADGKMV PIIPGGNSIP
4610 4620 4630 4640 4650
LTFSNRKEYV ERAIEYRLHE MDRQVAAVRE GMSWIVPVPL LSLLTAKQLE
4660 4670 4680 4690 4700
QMVCGMPEIS VEVLKKVVRY REVDEQHQLV QWFWHTLEEF SNEERVLFMR
4710 4720 4730 4740 4750
FVSGRSRLPA NTADISQRFQ IMKVDRPYDS LPTSQTCFFQ LRLPPYSSQL
4760 4770 4780
VMAERLRYAI NNCRSIDMDN YMLSRNVDNA EGSDTDY
Length:4,787
Mass (Da):524,422
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i71EA5EBD630093D5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2Y4U1A0A2I2Y4U1_GORGO
HECT and RLD domain containing E3 u...
4,861Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
G3SB97G3SB97_GORGO
HECT and RLD domain containing E3 u...
540Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2ZWP8A0A2I2ZWP8_GORGO
HECT and RLD domain containing E3 u...
108Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
CABD030096648 Genomic DNA No translation available.
CABD030096649 Genomic DNA No translation available.
CABD030096650 Genomic DNA No translation available.
CABD030096651 Genomic DNA No translation available.
CABD030096652 Genomic DNA No translation available.
CABD030096653 Genomic DNA No translation available.
CABD030096654 Genomic DNA No translation available.
CABD030096655 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSGGOT00000013210; ENSGGOP00000012839; ENSGGOG00000013126

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030096648 Genomic DNA No translation available.
CABD030096649 Genomic DNA No translation available.
CABD030096650 Genomic DNA No translation available.
CABD030096651 Genomic DNA No translation available.
CABD030096652 Genomic DNA No translation available.
CABD030096653 Genomic DNA No translation available.
CABD030096654 Genomic DNA No translation available.
CABD030096655 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000012839

Genome annotation databases

EnsembliENSGGOT00000013210; ENSGGOP00000012839; ENSGGOG00000013126

Phylogenomic databases

GeneTreeiENSGT00940000155907
HOGENOMiCLU_000091_0_0_1
InParanoidiG3RBI4
TreeFamiTF106426

Gene expression databases

BgeeiENSGGOG00000013126 Expressed in prefrontal cortex and 5 other tissues

Family and domain databases

CDDicd00078 HECTc, 1 hit
cd12881 SPRY_HERC1, 1 hit
Gene3Di2.130.10.10, 1 hit
2.130.10.30, 2 hits
InterProiView protein in InterPro
IPR001870 B30.2/SPRY
IPR013320 ConA-like_dom_sf
IPR000569 HECT_dom
IPR035983 Hect_E3_ubiquitin_ligase
IPR009091 RCC1/BLIP-II
IPR000408 Reg_chr_condens
IPR003877 SPRY_dom
IPR035768 SPRY_HERC1
IPR015943 WD40/YVTN_repeat-like_dom_sf
IPR001680 WD40_repeat
IPR019775 WD40_repeat_CS
IPR017986 WD40_repeat_dom
IPR036322 WD40_repeat_dom_sf
PfamiView protein in Pfam
PF00632 HECT, 1 hit
PF00415 RCC1, 10 hits
PF00622 SPRY, 1 hit
PF00400 WD40, 2 hits
PRINTSiPR00633 RCCNDNSATION
SMARTiView protein in SMART
SM00119 HECTc, 1 hit
SM00449 SPRY, 1 hit
SM00320 WD40, 5 hits
SUPFAMiSSF49899 SSF49899, 1 hit
SSF50978 SSF50978, 1 hit
SSF50985 SSF50985, 2 hits
SSF56204 SSF56204, 1 hit
PROSITEiView protein in PROSITE
PS50188 B302_SPRY, 1 hit
PS50237 HECT, 1 hit
PS00626 RCC1_2, 4 hits
PS50012 RCC1_3, 14 hits
PS00678 WD_REPEATS_1, 1 hit
PS50082 WD_REPEATS_2, 3 hits
PS50294 WD_REPEATS_REGION, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3RBI4_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3RBI4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: February 26, 2020
This is version 62 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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