Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transmembrane protease serine

Gene
N/A
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei230Charge relay systemUniRule annotation1
Active sitei275Charge relay systemUniRule annotation1
Active sitei371Charge relay systemUniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseUniRule annotation

Protein family/group databases

MEROPSiS01.292

Names & Taxonomyi

Protein namesi
Recommended name:
Transmembrane protease serineUniRule annotation (EC:3.4.21.-UniRule annotation)
OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
Taxonomic identifieri9595 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
Proteomesi
  • UP000001519 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei20 – 44HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000012200

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini47 – 167SEAInterPro annotationAdd BLAST121
Domaini190 – 420Peptidase S1InterPro annotationAdd BLAST231

Sequence similaritiesi

Belongs to the peptidase S1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

GeneTreeiENSGT00920000148977
InParanoidiG3R9V3
OMAiSWGDNCG
OrthoDBiEOG091G0AH5
TreeFamiTF351684

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3R9V3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY
60 70 80 90 100
YHGSFKILDP QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN
110 120 130 140 150
YIKNQVVRLT PEEDGVKVDV IMVFQFPSTE QRAVREKKIQ SILNQKIRNL
160 170 180 190 200
RALPINASSV QVNAMSSSTG ELTVQASCGK RVVPLNVNRI ASGVIAPKAA
210 220 230 240 250
WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ WTVSFGTKIN
260 270 280 290 300
PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS
310 320 330 340 350
ASFQPNLTVY ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI
360 370 380 390 400
KPGMFCAGYM EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD
410 420
KPGVYTQVTY YRNWIASKTG I
Length:421
Mass (Da):47,595
Last modified:February 28, 2018 - v2
Checksum:iB0537A6041A82318
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I2YAW0A0A2I2YAW0_GORGO
Transmembrane protease serine
403Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030030563 Genomic DNA No translation available.
CABD030030564 Genomic DNA No translation available.
RefSeqiXP_018880681.1, XM_019025136.1

Genome annotation databases

EnsembliENSGGOT00000012553; ENSGGOP00000012200; ENSGGOG00000012506
GeneIDi101127843

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030030563 Genomic DNA No translation available.
CABD030030564 Genomic DNA No translation available.
RefSeqiXP_018880681.1, XM_019025136.1

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000012200

Protein family/group databases

MEROPSiS01.292

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGGOT00000012553; ENSGGOP00000012200; ENSGGOG00000012506
GeneIDi101127843

Organism-specific databases

CTDi339967

Phylogenomic databases

GeneTreeiENSGT00920000148977
InParanoidiG3R9V3
OMAiSWGDNCG
OrthoDBiEOG091G0AH5
TreeFamiTF351684

Family and domain databases

CDDicd00190 Tryp_SPc, 1 hit
Gene3Di3.30.70.960, 1 hit
InterProiView protein in InterPro
IPR017329 Pept_S1A_HAT/DESC1
IPR009003 Peptidase_S1_PA
IPR001314 Peptidase_S1A
IPR000082 SEA_dom
IPR036364 SEA_dom_sf
IPR001254 Trypsin_dom
IPR018114 TRYPSIN_HIS
IPR033116 TRYPSIN_SER
PfamiView protein in Pfam
PF01390 SEA, 1 hit
PF00089 Trypsin, 1 hit
PIRSFiPIRSF037941 TMPRSS11ABCDE, 1 hit
PRINTSiPR00722 CHYMOTRYPSIN
SMARTiView protein in SMART
SM00020 Tryp_SPc, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
SSF82671 SSF82671, 1 hit
PROSITEiView protein in PROSITE
PS50024 SEA, 1 hit
PS50240 TRYPSIN_DOM, 1 hit
PS00134 TRYPSIN_HIS, 1 hit
PS00135 TRYPSIN_SER, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiG3R9V3_GORGO
AccessioniPrimary (citable) accession number: G3R9V3
Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: October 10, 2018
This is version 47 of the entry and version 2 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again