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Entry version 54 (07 Apr 2021)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

TUB like protein 4

Gene

TULP4

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.ARBA annotation
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00143

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
TUB like protein 4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TULP4Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000012077, Expressed in prefrontal cortex and 6 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000011788

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini336 – 377SOCS boxInterPro annotationAdd BLAST42

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni493 – 540DisorderedSequence analysisAdd BLAST48
Regioni946 – 1001DisorderedSequence analysisAdd BLAST56
Regioni1269 – 1298DisorderedSequence analysisAdd BLAST30
Regioni1310 – 1396DisorderedSequence analysisAdd BLAST87

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi979 – 1001PolarSequence analysisAdd BLAST23
Compositional biasi1272 – 1289PolyampholyteSequence analysisAdd BLAST18
Compositional biasi1319 – 1348PolyampholyteSequence analysisAdd BLAST30
Compositional biasi1377 – 1396PolyampholyteSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TUB family.ARBA annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2503, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155913

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3R8S0

Identification of Orthologs from Complete Genome Data

More...
OMAi
CRNNMNP

TreeFam database of animal gene trees

More...
TreeFami
TF314076

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.90.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001496, SOCS_box
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR008983, Tumour_necrosis_fac-like_dom
IPR036322, WD40_repeat_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01167, Tub, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01573, SUPERTUBBY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00969, SOCS_box, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49842, SSF49842, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50225, SOCS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

G3R8S0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
RERSVPYGPG LCRSKRECLE LQGRLYSPGG KGQKGVPGQG WHEACGDVVL
60 70 80 90 100
VRWNEPYQKL ATCDADGGIF VWIQYEGRWS VELVNDRGAQ VSDFTWSHDG
110 120 130 140 150
TQALISYRDG FVLVGSVSGQ RHWSSEINLE SQITCGIWTP DDQQVLFGTA
160 170 180 190 200
DGQVIVMDCH GRMLAHVLLH ESDGVLGMSW NYPIFLVEDS SESDTDSDDY
210 220 230 240 250
APPQDGPAAY PIPVQNIKPL LTISFTSGDI SLMNNYDDLS PTVIRSGLKE
260 270 280 290 300
VVAQWCTQGD LLAVAGMERQ TQLGELPNGP LLKSAMVKFY NVRGEHIFTL
310 320 330 340 350
DTLVQRPIIS ICWGHRDSRL LMASGPALYV VRVEHRVSSL QLLCQQAIAS
360 370 380 390 400
TLREDKDVSK LTLPPRLCSY LSTAFIPTIK PPIPDPNNMR DFVSYPSAGN
410 420 430 440 450
ERLHCTMKRT EDDPEVGGPC YTLYLEYLGG LVPILKGRRV SKLRPEFVIM
460 470 480 490 500
DPRTDSKPDE IYGNSLISTV IDSCNCSDSS DIELSDDWAA KKSPKISRAS
510 520 530 540 550
KSPKLPRISI EARKSPKLPR AAQELSRSPR LPLRKPSVGS PSLTRREFPF
560 570 580 590 600
EDITQVGAPS YPALLPSSWG LCPEGPFLPT ALIYKTSLLH LQPRQMTIYL
610 620 630 640 650
PEVRKISMDY INLPVFNPNV FSEDEDDLPV TGASGVPENS PPCTVNIPIA
660 670 680 690 700
PIHSSAQAMS PTQSIGLVQS LLANQNVQLD VLTNQTTAVG AAEHAGDSAT
710 720 730 740 750
QYPVSNRYSN PGQVIFGSVE MGRIIQNPPP LSLPPPPQGP MQLSTVGHGD
760 770 780 790 800
RDHEHLQKSA KALRPAPQLA AEGDAVVFSA PQEVQVTKIN PPPPYPGTIP
810 820 830 840 850
APPVDVCLKK GDFSLYPTSV HYQTPLGYER ITTFDSSGNV EEVCRPRTRM
860 870 880 890 900
LCSQNTYTLP GPGSSATLRL TATEKKVPQP CSSATLNRLT VPRYSIPTGD
910 920 930 940 950
PPPYPEIASQ LAQGRGAAQR SDNSLIHATL RRNNREATLK MAQLADSPRA
960 970 980 990 1000
PLQPLAKSKG GPGGVVTQLP ARPPPALYTC SQCSGTGPSS QPGASLAHTA
1010 1020 1030 1040 1050
SASPLASQSS YSLLSPPDSA RDRTDYVNSA FTEDEALSQH CQLEKPLRHP
1060 1070 1080 1090 1100
PLPEAAVTLK RPPPYQWDPM LGEDVWVPQE RTAQTSGPNP LKLSPLMLSQ
1110 1120 1130 1140 1150
GQHLDVSRLP FISPKSPASP TATFQTGYGM GVPYPGSYNN PPLPGVQAPC
1160 1170 1180 1190 1200
SPKDALSPTQ FAQQEPAVVL QPVYPPSLSY CTLPPMYPGS STCSSLQLPP
1210 1220 1230 1240 1250
VALHPWSSYS ACPPMQNPQG TLPPKPHLVV EKPLVSPPPA DLQSHMGTEV
1260 1270 1280 1290 1300
MVETADNFQE VLSLTESPVP QRTEKFGKKN RKRLDSRAEE GSVQAITEGK
1310 1320 1330 1340 1350
VKKEARTLSD FNSLISSPHL GREKKKVKSQ KDQLKSKKLN KTNEFQDSSE
1360 1370 1380 1390 1400
SEPELFISGD ELMNQSQGSR KGWKSKRSPR AAGELEEAKC RRASEKEDGR
1410 1420 1430 1440 1450
LGSQGFVYVM ANKQPLWNEA TQVYQLDFGG RVTQESAKNF QIELEGRQVM
1460 1470 1480
QFGRIDGNAY ILDFQYPFSA VQAFAVALAN VTQRLK
Length:1,486
Mass (Da):162,391
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3B238FC76FAD66F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3S2Z0G3S2Z0_GORGO
TUB like protein 4
TULP4
678Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030048673 Genomic DNA No translation available.
CABD030048674 Genomic DNA No translation available.
CABD030048675 Genomic DNA No translation available.
CABD030048676 Genomic DNA No translation available.
CABD030048677 Genomic DNA No translation available.
CABD030048678 Genomic DNA No translation available.
CABD030048679 Genomic DNA No translation available.
CABD030048680 Genomic DNA No translation available.
CABD030048681 Genomic DNA No translation available.
CABD030048682 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000012129; ENSGGOP00000011788; ENSGGOG00000012077

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030048673 Genomic DNA No translation available.
CABD030048674 Genomic DNA No translation available.
CABD030048675 Genomic DNA No translation available.
CABD030048676 Genomic DNA No translation available.
CABD030048677 Genomic DNA No translation available.
CABD030048678 Genomic DNA No translation available.
CABD030048679 Genomic DNA No translation available.
CABD030048680 Genomic DNA No translation available.
CABD030048681 Genomic DNA No translation available.
CABD030048682 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000011788

Genome annotation databases

EnsembliENSGGOT00000012129; ENSGGOP00000011788; ENSGGOG00000012077

Phylogenomic databases

eggNOGiKOG2503, Eukaryota
GeneTreeiENSGT00940000155913
InParanoidiG3R8S0
OMAiCRNNMNP
TreeFamiTF314076

Enzyme and pathway databases

UniPathwayiUPA00143

Gene expression databases

BgeeiENSGGOG00000012077, Expressed in prefrontal cortex and 6 other tissues

Family and domain databases

Gene3Di3.20.90.10, 1 hit
InterProiView protein in InterPro
IPR001496, SOCS_box
IPR025659, Tubby-like_C
IPR000007, Tubby_C
IPR008983, Tumour_necrosis_fac-like_dom
IPR036322, WD40_repeat_dom_sf
PfamiView protein in Pfam
PF01167, Tub, 1 hit
PRINTSiPR01573, SUPERTUBBY
SMARTiView protein in SMART
SM00969, SOCS_box, 1 hit
SUPFAMiSSF49842, SSF49842, 1 hit
SSF50978, SSF50978, 1 hit
SSF54518, SSF54518, 1 hit
PROSITEiView protein in PROSITE
PS50225, SOCS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3R8S0_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3R8S0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: April 7, 2021
This is version 54 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termi

Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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