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UniProtKB - G3R698 (G3R698_GORGO)
Protein
AP-3 complex subunit mu-1
Gene
AP3M1
Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Functioni
Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes.
UniRule annotationGO - Molecular functioni
- small GTPase binding Source: Ensembl
GO - Biological processi
- anterograde synaptic vesicle transport Source: Ensembl
- endocytosis Source: GO_Central
- intracellular protein transport Source: UniProtKB-UniRule
- vesicle-mediated transport Source: GO_Central
Keywordsi
Biological process | Protein transportUniRule annotationARBA annotation, Transport |
Names & Taxonomyi
Protein namesi | Recommended name: AP-3 complex subunit mu-1UniRule annotation |
Gene namesi | Name:AP3M1Imported |
Organismi | Gorilla gorilla gorilla (Western lowland gorilla)Imported |
Taxonomic identifieri | 9595 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Gorilla › |
Proteomesi |
|
Subcellular locationi
Golgi apparatus
- Golgi apparatus UniRule annotation
Other locations
- Cytoplasmic vesicle membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
Golgi apparatus
- Golgi apparatus Source: UniProtKB-SubCell
Other locations
- axon cytoplasm Source: GOC
- clathrin adaptor complex Source: UniProtKB-UniRule
- cytoplasmic vesicle Source: GO_Central
- cytoplasmic vesicle membrane Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasmic vesicleUniRule annotation, Golgi apparatusUniRule annotation, MembraneUniRule annotationARBA annotationExpressioni
Gene expression databases
Bgeei | ENSGGOG00000011120, Expressed in liver and 7 other tissues |
Interactioni
GO - Molecular functioni
- small GTPase binding Source: Ensembl
Protein-protein interaction databases
STRINGi | 9593.ENSGGOP00000010841 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 176 – 417 | MHDInterPro annotationAdd BLAST | 242 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG2740, Eukaryota |
GeneTreei | ENSGT00940000158184 |
HOGENOMi | CLU_026996_6_2_1 |
InParanoidi | G3R698 |
OMAi | HWKSVIH |
OrthoDBi | 928391at2759 |
TreeFami | TF315187 |
Family and domain databases
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR022775, AP_mu_sigma_su IPR001392, Clathrin_mu IPR018240, Clathrin_mu_CS IPR011012, Longin-like_dom_sf IPR028565, MHD |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit PF01217, Clat_adaptor_s, 1 hit |
PIRSFi | PIRSF005992, Clathrin_mu, 1 hit |
PRINTSi | PR00314, CLATHRINADPT |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00990, CLAT_ADAPTOR_M_1, 1 hit PS00991, CLAT_ADAPTOR_M_2, 1 hit PS51072, MHD, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
G3R698-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS
60 70 80 90 100
TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA
110 120 130 140 150
AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS
160 170 180 190 200
SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA
210 220 230 240 250
EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF
260 270 280 290 300
IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN
310 320 330 340 350
MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLT WDVGKITPQK
360 370 380 390 400
LPSLKGLVNL QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK
410
PFKGVKYVTK AGKFQVRT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2I2YRR3 | A0A2I2YRR3_GORGO | AP-3 complex subunit mu-1 | AP3M1 | 362 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030069917 Genomic DNA No translation available. CABD030069918 Genomic DNA No translation available. |
RefSeqi | XP_004049666.1, XM_004049618.2 XP_004049667.1, XM_004049619.2 |
Genome annotation databases
Ensembli | ENSGGOT00000011162; ENSGGOP00000010841; ENSGGOG00000011120 |
GeneIDi | 101140815 |
KEGGi | ggo:101140815 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | CABD030069917 Genomic DNA No translation available. CABD030069918 Genomic DNA No translation available. |
RefSeqi | XP_004049666.1, XM_004049618.2 XP_004049667.1, XM_004049619.2 |
3D structure databases
SMRi | G3R698 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9593.ENSGGOP00000010841 |
Genome annotation databases
Ensembli | ENSGGOT00000011162; ENSGGOP00000010841; ENSGGOG00000011120 |
GeneIDi | 101140815 |
KEGGi | ggo:101140815 |
Organism-specific databases
CTDi | 26985 |
Phylogenomic databases
eggNOGi | KOG2740, Eukaryota |
GeneTreei | ENSGT00940000158184 |
HOGENOMi | CLU_026996_6_2_1 |
InParanoidi | G3R698 |
OMAi | HWKSVIH |
OrthoDBi | 928391at2759 |
TreeFami | TF315187 |
Gene expression databases
Bgeei | ENSGGOG00000011120, Expressed in liver and 7 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR036168, AP2_Mu_C_sf IPR022775, AP_mu_sigma_su IPR001392, Clathrin_mu IPR018240, Clathrin_mu_CS IPR011012, Longin-like_dom_sf IPR028565, MHD |
Pfami | View protein in Pfam PF00928, Adap_comp_sub, 1 hit PF01217, Clat_adaptor_s, 1 hit |
PIRSFi | PIRSF005992, Clathrin_mu, 1 hit |
PRINTSi | PR00314, CLATHRINADPT |
SUPFAMi | SSF49447, SSF49447, 1 hit SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS00990, CLAT_ADAPTOR_M_1, 1 hit PS00991, CLAT_ADAPTOR_M_2, 1 hit PS51072, MHD, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | G3R698_GORGO | |
Accessioni | G3R698Primary (citable) accession number: G3R698 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 16, 2011 |
Last sequence update: | November 16, 2011 | |
Last modified: | January 19, 2022 | |
This is version 66 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |