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Entry version 48 (02 Jun 2021)
Sequence version 2 (28 Feb 2018)
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Protein
Submitted name:

RPGR interacting protein 1

Gene

RPGRIP1

Organism
Gorilla gorilla gorilla (Western lowland gorilla)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
RPGR interacting protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:RPGRIP1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGorilla gorilla gorilla (Western lowland gorilla)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9595 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeGorilla
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001519 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell projection, CiliumARBA annotation

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSGGOG00000010820, Expressed in testis and 3 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
9593.ENSGGOP00000010557

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini620 – 758C2-C2_1InterPro annotationAdd BLAST139
Domaini802 – 909C2InterPro annotationAdd BLAST108
Domaini1115 – 1280RPGR1_CInterPro annotationAdd BLAST166

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 199DisorderedSequence analysisAdd BLAST56
Regioni935 – 1010DisorderedSequence analysisAdd BLAST76
Regioni1059 – 1109DisorderedSequence analysisAdd BLAST51

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili317 – 385Sequence analysisAdd BLAST69
Coiled coili404 – 463Sequence analysisAdd BLAST60
Coiled coili538 – 579Sequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi940 – 957Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi982 – 1002Basic and acidic residuesSequence analysisAdd BLAST21
Compositional biasi1059 – 1088Basic and acidic residuesSequence analysisAdd BLAST30
Compositional biasi1089 – 1103Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the RPGRIP1 family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502R3GU, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055620

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002108_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
G3R5I0

TreeFam database of animal gene trees

More...
TreeFami
TF328883

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.150, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR021656, C2-C2_1
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR031134, RPGRIP1
IPR041091, RPGRIP1_C
IPR031139, RPGRIP1_fam

The PANTHER Classification System

More...
PANTHERi
PTHR14240, PTHR14240, 1 hit
PTHR14240:SF3, PTHR14240:SF3, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00168, C2, 1 hit
PF11618, C2-C2_1, 1 hit
PF18111, RPGR1_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

G3R5I0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSHLVDPTSG DLPVRDIDAI PLVLPASKGK NMKTQPPLSR MNREELEDSF
60 70 80 90 100
FRLREDHMLV KELSWKQQDE IKRLRTTLLR LTAAGRDLRV AEEAAPLSET
110 120 130 140 150
ARRGQNAGWR QRLSMHQRPQ MHRLQGHFHR VGPASPRRAQ SRVHVGHRQL
160 170 180 190 200
HTAGAPVPEK PKRGPRDRLS YTAPPSFKEH ATNENRGEVA PEPSELASGS
210 220 230 240 250
NSIISFSSVI SMAKPIGLCM PNSAHIMASN TMQVEEPPKS PEKMWPKDEN
260 270 280 290 300
FEQRSSLECA QKAAELRASI KEKVELIQLK KLLHERNASL VMTKAQLTEV
310 320 330 340 350
QEVSCTFLLP QNQGILSAAH EALLKQVNEL RAELKEESKK AVSLKSQLED
360 370 380 390 400
VSILQMTLKE FQERVEDLEK ERKLLNDNYD KLLESTLDSS DSSSQPHWSN
410 420 430 440 450
ELIAEQLQQQ VSQLQDQLDA ELEDKRKVLL ELSREKAQNE DLKLEVTNIL
460 470 480 490 500
QKHKQEVELL QNAATISQPP DRQSEPATHP AVLQENTQIE PSEPKNQEEK
510 520 530 540 550
KLSQVLNELQ VSHAETTLEL EKTRDMLILQ RKINVCYQEE LEAMMTKADN
560 570 580 590 600
DNRDHKEKLE RLTRLLDLKN NRIKQLEGTL RSHDLPTSEQ LKDVAYGTRQ
610 620 630 640 650
LSLCLETLPA HGDEDKVDIS LLHQGENLFE LHIHQAFLTS AALAQAGDTQ
660 670 680 690 700
PTTFCTYSFY DFETHCTPLS VGPQPLYDFT SQYVMETDSL FLHYLQEASA
710 720 730 740 750
RLDVHQAVAS EHSTLAAGWI CFDRVLETVE KVHGLATLIG AGGEEFGVLE
760 770 780 790 800
YWMRLRFPIK PSLQACNKRK KAQVYLSTDV LGGRKAQEEE FRSESWEPQN
810 820 830 840 850
ELWIEITKCC GLRSRWLGTQ PSPYAVYRFF TFSDHDTAII PASNNPYFRD
860 870 880 890 900
QARFPVLVTS DLDQYLRREA LSIHVFDDED LEPGSYLGRA RVPLLPLAKN
910 920 930 940 950
ESIKGDFNLT DPAEKPNGSI QVQLDWKFPY IPPESFLKPE AQTKGKDTKD
960 970 980 990 1000
SSKISSEEEK ASFPSQDQMA SPGVPIEAGQ YRSKRKPPHG GERKEKEHQI
1010 1020 1030 1040 1050
VSYSRRKHGK RIGVQGKNRM EYLSLNILNG NTPEQVNYTE WKFSETNSFI
1060 1070 1080 1090 1100
GDGFKNQHEE EEMTLSHSEL KQKEPLHPVN DKESSEQGSE VSEAQTTDSD
1110 1120 1130 1140 1150
DVIVPPMSQK YPKADSEKMC IEIVSLAFYP EAEVMSDENI KQVYVEYKFY
1160 1170 1180 1190 1200
DLPLSETETP VSLRKPRAGE EIHFHFSKVI DLDPQEQQGR RRFLFDMLNG
1210 1220 1230 1240 1250
QDPDQGHLKF TVVSDPLDEE KKECEEVGYA YLQLWQILES GRDVLEQELD
1260 1270 1280
IVSPEDLATP IGRLKVSLQA AAVLHAIYKE MTEDLFS
Length:1,287
Mass (Da):146,636
Last modified:February 28, 2018 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61BD41F586EF1597
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3RY05G3RY05_GORGO
RPGR interacting protein 1
RPGRIP1
1,286Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2I2YP78A0A2I2YP78_GORGO
RPGR interacting protein 1
RPGRIP1
944Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
CABD030091945 Genomic DNA No translation available.
CABD030091946 Genomic DNA No translation available.
CABD030091947 Genomic DNA No translation available.
CABD030091948 Genomic DNA No translation available.

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSGGOT00000010868; ENSGGOP00000010557; ENSGGOG00000010820

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CABD030091945 Genomic DNA No translation available.
CABD030091946 Genomic DNA No translation available.
CABD030091947 Genomic DNA No translation available.
CABD030091948 Genomic DNA No translation available.

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi9593.ENSGGOP00000010557

Genome annotation databases

EnsembliENSGGOT00000010868; ENSGGOP00000010557; ENSGGOG00000010820

Phylogenomic databases

eggNOGiENOG502R3GU, Eukaryota
GeneTreeiENSGT00520000055620
HOGENOMiCLU_002108_1_0_1
InParanoidiG3R5I0
TreeFamiTF328883

Gene expression databases

BgeeiENSGGOG00000010820, Expressed in testis and 3 other tissues

Family and domain databases

Gene3Di2.60.40.150, 3 hits
InterProiView protein in InterPro
IPR021656, C2-C2_1
IPR000008, C2_dom
IPR035892, C2_domain_sf
IPR031134, RPGRIP1
IPR041091, RPGRIP1_C
IPR031139, RPGRIP1_fam
PANTHERiPTHR14240, PTHR14240, 1 hit
PTHR14240:SF3, PTHR14240:SF3, 1 hit
PfamiView protein in Pfam
PF00168, C2, 1 hit
PF11618, C2-C2_1, 1 hit
PF18111, RPGR1_C, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiG3R5I0_GORGO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: G3R5I0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 16, 2011
Last sequence update: February 28, 2018
Last modified: June 2, 2021
This is version 48 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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